First Report of Sorafenib in Patients With Acute Myeloid Leukemia Harboring Non-Canonical FLT3 Mutations
The prognostics implications of patients with acute myeloid leukemia harboring non-canonical FLT3 is unknown. The use of tyrosine kinase inhibitors in this patient population has not been previously reported. We report successful targeted therapy against non-ITD, non-D835 driver FLT3 alterations in...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2020-08-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fonc.2020.01538/full |
| _version_ | 1819228295606042624 |
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| author | Naval Daver Allyson Price Christopher B. Benton Keyur Patel Weiguo Zhang Marina Konopleva Naveen Pemmaraju Koichi Takahashi Michael Andreeff Gautam Borthakur |
| author_facet | Naval Daver Allyson Price Christopher B. Benton Keyur Patel Weiguo Zhang Marina Konopleva Naveen Pemmaraju Koichi Takahashi Michael Andreeff Gautam Borthakur |
| author_sort | Naval Daver |
| collection | DOAJ |
| description | The prognostics implications of patients with acute myeloid leukemia harboring non-canonical FLT3 is unknown. The use of tyrosine kinase inhibitors in this patient population has not been previously reported. We report successful targeted therapy against non-ITD, non-D835 driver FLT3 alterations in two patient case studies with acute myeloid leukemia. |
| first_indexed | 2024-12-23T10:55:01Z |
| format | Article |
| id | doaj.art-e9d0483f1b994cf998300389992288c5 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-23T10:55:01Z |
| publishDate | 2020-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-e9d0483f1b994cf998300389992288c52022-12-21T17:49:48ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2020-08-011010.3389/fonc.2020.01538553154First Report of Sorafenib in Patients With Acute Myeloid Leukemia Harboring Non-Canonical FLT3 MutationsNaval DaverAllyson PriceChristopher B. BentonKeyur PatelWeiguo ZhangMarina KonoplevaNaveen PemmarajuKoichi TakahashiMichael AndreeffGautam BorthakurThe prognostics implications of patients with acute myeloid leukemia harboring non-canonical FLT3 is unknown. The use of tyrosine kinase inhibitors in this patient population has not been previously reported. We report successful targeted therapy against non-ITD, non-D835 driver FLT3 alterations in two patient case studies with acute myeloid leukemia.https://www.frontiersin.org/article/10.3389/fonc.2020.01538/fullsorafenibFLT3 mutationFLT3-V592FLT3-N676AMLTKI |
| spellingShingle | Naval Daver Allyson Price Christopher B. Benton Keyur Patel Weiguo Zhang Marina Konopleva Naveen Pemmaraju Koichi Takahashi Michael Andreeff Gautam Borthakur First Report of Sorafenib in Patients With Acute Myeloid Leukemia Harboring Non-Canonical FLT3 Mutations Frontiers in Oncology sorafenib FLT3 mutation FLT3-V592 FLT3-N676 AML TKI |
| title | First Report of Sorafenib in Patients With Acute Myeloid Leukemia Harboring Non-Canonical FLT3 Mutations |
| title_full | First Report of Sorafenib in Patients With Acute Myeloid Leukemia Harboring Non-Canonical FLT3 Mutations |
| title_fullStr | First Report of Sorafenib in Patients With Acute Myeloid Leukemia Harboring Non-Canonical FLT3 Mutations |
| title_full_unstemmed | First Report of Sorafenib in Patients With Acute Myeloid Leukemia Harboring Non-Canonical FLT3 Mutations |
| title_short | First Report of Sorafenib in Patients With Acute Myeloid Leukemia Harboring Non-Canonical FLT3 Mutations |
| title_sort | first report of sorafenib in patients with acute myeloid leukemia harboring non canonical flt3 mutations |
| topic | sorafenib FLT3 mutation FLT3-V592 FLT3-N676 AML TKI |
| url | https://www.frontiersin.org/article/10.3389/fonc.2020.01538/full |
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