Loganin Attenuates High Glucose-Induced Schwann Cells Pyroptosis by Inhibiting ROS Generation and NLRP3 Inflammasome Activation

Loganin Attenuates High Glucose-Induced Schwann Cells Pyroptosis by Inhibiting ROS Generation and NLRP3 Inflammasome Activation

Diabetic peripheral neuropathy (DPN) is caused by hyperglycemia, which induces oxidative stress and inflammatory responses that damage nerve tissue. Excessive generation of reactive oxygen species (ROS) and NOD-like receptor protein 3 (NLRP3) inflammasome activation trigger the inflammation and pyro...

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Bibliographic Details
Main Authors: Yu-Chi Cheng, Li-Wen Chu, Jun-Yih Chen, Su-Ling Hsieh, Yu-Chin Chang, Zen-Kong Dai, Bin-Nan Wu
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Cells
Subjects:
Schwann cell
loganin
high glucose
reactive oxygen species
NLRP3 inflammasome
pyroptosis
Online Access:https://www.mdpi.com/2073-4409/9/9/1948

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