The leucoglycaemic index is a predictor of one-year all-cause mortality in Cuban patients with ST-segment elevation acute myocardial infarction
Introduction: The leuko-glycaemic index has been proposed as a prognostic marker of death in patients with acute myocardial infarction, but there is uncertainty surrounding its prognostic value to predict one-year mortality. Objectives: The aim of this study was to determine the prognostic value of...
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| Format: | Article |
| Language: | English |
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Cardiocentro Ernesto Che Guevara
2019-01-01
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| Series: | CorSalud |
| Online Access: | http://www.revcorsalud.sld.cu/index.php/cors/article/view/345 |
| _version_ | 1811287721970237440 |
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| author | David Padilla-Cueto Halbert Hernández-Negrín José I. Ramírez-Gómez Arlenys Pérez-Valdivia Ana L. Cárdenas-Sánchez Adrián Alfonso-Izquierdo |
| author_facet | David Padilla-Cueto Halbert Hernández-Negrín José I. Ramírez-Gómez Arlenys Pérez-Valdivia Ana L. Cárdenas-Sánchez Adrián Alfonso-Izquierdo |
| author_sort | David Padilla-Cueto |
| collection | DOAJ |
| description | Introduction: The leuko-glycaemic index has been proposed as a prognostic marker of death in patients with acute myocardial infarction, but there is uncertainty surrounding its prognostic value to predict one-year mortality.
Objectives: The aim of this study was to determine the prognostic value of leuko-glycaemic index for one-year mortality in Cuban patients with ST-segment elevation myocardial infarction.
Method: The data were obtained from the medical records and all cause one-year deaths was the primary endpoint. The leuko-glycaemic index was calculated from measurements at admission. The patients were divided into leuko-glycaemic index tertiles to be evaluated. Receiver operating characteristics and Kaplan-Meier survival curves were performed. Cox regression model was used for all multivariable analysis.
Results: Three hundred and forty-four patients were assessed (median age, 68 years, 65.7% males, 25.6% diabetic). The mortality rate was 25.6%, being significantly higher in the upper tertile (55.7%, p<0.0001). The deceased patients presented a median of leuko-glycaemic index significantly higher than the survivors (2.18 and 1.34 respectively, p<0.0001). The area under the curve for leuko-glycaemic index was 0.715 and its cut-off value was 2.2. Any leuko-glycaemic index value higher than 2.2 was associated with significantly lower survival (177 vs. 309 days, p<0.0001) and it was an independent predictor of mortality (HR=3.56, CI 95%, 2.09-6.07, p<0.0001).
Conclusions: The leuko-glycaemic index is a good predictor for one-year all cause mortality in patients with ST-segment elevation myocardial infarction. |
| first_indexed | 2024-04-13T03:23:14Z |
| format | Article |
| id | doaj.art-e9d285ba3ce648efae895a668d897205 |
| institution | Directory Open Access Journal |
| issn | 2078-7170 |
| language | English |
| last_indexed | 2024-04-13T03:23:14Z |
| publishDate | 2019-01-01 |
| publisher | Cardiocentro Ernesto Che Guevara |
| record_format | Article |
| series | CorSalud |
| spelling | doaj.art-e9d285ba3ce648efae895a668d8972052022-12-22T03:04:43ZengCardiocentro Ernesto Che GuevaraCorSalud2078-71702019-01-011112129340The leucoglycaemic index is a predictor of one-year all-cause mortality in Cuban patients with ST-segment elevation acute myocardial infarctionDavid Padilla-CuetoHalbert Hernández-NegrínJosé I. Ramírez-GómezArlenys Pérez-ValdiviaAna L. Cárdenas-SánchezAdrián Alfonso-IzquierdoIntroduction: The leuko-glycaemic index has been proposed as a prognostic marker of death in patients with acute myocardial infarction, but there is uncertainty surrounding its prognostic value to predict one-year mortality. Objectives: The aim of this study was to determine the prognostic value of leuko-glycaemic index for one-year mortality in Cuban patients with ST-segment elevation myocardial infarction. Method: The data were obtained from the medical records and all cause one-year deaths was the primary endpoint. The leuko-glycaemic index was calculated from measurements at admission. The patients were divided into leuko-glycaemic index tertiles to be evaluated. Receiver operating characteristics and Kaplan-Meier survival curves were performed. Cox regression model was used for all multivariable analysis. Results: Three hundred and forty-four patients were assessed (median age, 68 years, 65.7% males, 25.6% diabetic). The mortality rate was 25.6%, being significantly higher in the upper tertile (55.7%, p<0.0001). The deceased patients presented a median of leuko-glycaemic index significantly higher than the survivors (2.18 and 1.34 respectively, p<0.0001). The area under the curve for leuko-glycaemic index was 0.715 and its cut-off value was 2.2. Any leuko-glycaemic index value higher than 2.2 was associated with significantly lower survival (177 vs. 309 days, p<0.0001) and it was an independent predictor of mortality (HR=3.56, CI 95%, 2.09-6.07, p<0.0001). Conclusions: The leuko-glycaemic index is a good predictor for one-year all cause mortality in patients with ST-segment elevation myocardial infarction.http://www.revcorsalud.sld.cu/index.php/cors/article/view/345 |
| spellingShingle | David Padilla-Cueto Halbert Hernández-Negrín José I. Ramírez-Gómez Arlenys Pérez-Valdivia Ana L. Cárdenas-Sánchez Adrián Alfonso-Izquierdo The leucoglycaemic index is a predictor of one-year all-cause mortality in Cuban patients with ST-segment elevation acute myocardial infarction CorSalud |
| title | The leucoglycaemic index is a predictor of one-year all-cause mortality in Cuban patients with ST-segment elevation acute myocardial infarction |
| title_full | The leucoglycaemic index is a predictor of one-year all-cause mortality in Cuban patients with ST-segment elevation acute myocardial infarction |
| title_fullStr | The leucoglycaemic index is a predictor of one-year all-cause mortality in Cuban patients with ST-segment elevation acute myocardial infarction |
| title_full_unstemmed | The leucoglycaemic index is a predictor of one-year all-cause mortality in Cuban patients with ST-segment elevation acute myocardial infarction |
| title_short | The leucoglycaemic index is a predictor of one-year all-cause mortality in Cuban patients with ST-segment elevation acute myocardial infarction |
| title_sort | leucoglycaemic index is a predictor of one year all cause mortality in cuban patients with st segment elevation acute myocardial infarction |
| url | http://www.revcorsalud.sld.cu/index.php/cors/article/view/345 |
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