Integration of Genomic and Other Epidemiologic Data to Investigate and Control a Cross-Institutional Outbreak of Streptococcus pyogenes
Single-strain outbreaks of Streptococcus pyogenes infections are common and often go undetected. In 2013, two clusters of invasive group A Streptococcus (iGAS) infection were identified in independent but closely located care homes in Oxfordshire, United Kingdom. Investigation included visits to eac...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Centers for Disease Control and Prevention
2016-06-01
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| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/22/6/14-2050_article |
| _version_ | 1818543278599962624 |
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| author | Victoria J. Chalker Alyson Smith Ali Al-Shahib Stella Botchway Emily Macdonald Roger Daniel Sarah Phillips Steven Platt Michel Doumith Rediat Tewolde Juliana Coelho Keith A. Jolley Anthony Underwood Noel McCarthy |
| author_facet | Victoria J. Chalker Alyson Smith Ali Al-Shahib Stella Botchway Emily Macdonald Roger Daniel Sarah Phillips Steven Platt Michel Doumith Rediat Tewolde Juliana Coelho Keith A. Jolley Anthony Underwood Noel McCarthy |
| author_sort | Victoria J. Chalker |
| collection | DOAJ |
| description | Single-strain outbreaks of Streptococcus pyogenes infections are common and often go undetected. In 2013, two clusters of invasive group A Streptococcus (iGAS) infection were identified in independent but closely located care homes in Oxfordshire, United Kingdom. Investigation included visits to each home, chart review, staff survey, microbiologic sampling, and genome sequencing. S. pyogenes emm type 1.0, the most common circulating type nationally, was identified from all cases yielding GAS isolates. A tailored whole-genome reference population comprising epidemiologically relevant contemporaneous isolates and published isolates was assembled. Data were analyzed independently using whole-genome multilocus sequencing and single-nucleotide polymorphism analyses. Six isolates from staff and residents of the homes formed a single cluster that was separated from the reference population by both analytical approaches. No further cases occurred after mass chemoprophylaxis and enhanced infection control. Our findings demonstrate the ability of 2 independent analytical approaches to enable robust conclusions from nonstandardized whole-genome analysis to support public health practice. |
| first_indexed | 2024-12-11T22:33:16Z |
| format | Article |
| id | doaj.art-e9d2e584b3fb470fb0fc05fd252101ea |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-12-11T22:33:16Z |
| publishDate | 2016-06-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-e9d2e584b3fb470fb0fc05fd252101ea2022-12-22T00:48:04ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592016-06-0122697398010.3201/eid2206.142050Integration of Genomic and Other Epidemiologic Data to Investigate and Control a Cross-Institutional Outbreak of Streptococcus pyogenesVictoria J. ChalkerAlyson SmithAli Al-ShahibStella BotchwayEmily MacdonaldRoger DanielSarah PhillipsSteven PlattMichel DoumithRediat TewoldeJuliana CoelhoKeith A. JolleyAnthony UnderwoodNoel McCarthySingle-strain outbreaks of Streptococcus pyogenes infections are common and often go undetected. In 2013, two clusters of invasive group A Streptococcus (iGAS) infection were identified in independent but closely located care homes in Oxfordshire, United Kingdom. Investigation included visits to each home, chart review, staff survey, microbiologic sampling, and genome sequencing. S. pyogenes emm type 1.0, the most common circulating type nationally, was identified from all cases yielding GAS isolates. A tailored whole-genome reference population comprising epidemiologically relevant contemporaneous isolates and published isolates was assembled. Data were analyzed independently using whole-genome multilocus sequencing and single-nucleotide polymorphism analyses. Six isolates from staff and residents of the homes formed a single cluster that was separated from the reference population by both analytical approaches. No further cases occurred after mass chemoprophylaxis and enhanced infection control. Our findings demonstrate the ability of 2 independent analytical approaches to enable robust conclusions from nonstandardized whole-genome analysis to support public health practice.https://wwwnc.cdc.gov/eid/article/22/6/14-2050_articleGroup A Streptococcusinvasive group A streptococcal infectioniGASoutbreakgenomeinfection control |
| spellingShingle | Victoria J. Chalker Alyson Smith Ali Al-Shahib Stella Botchway Emily Macdonald Roger Daniel Sarah Phillips Steven Platt Michel Doumith Rediat Tewolde Juliana Coelho Keith A. Jolley Anthony Underwood Noel McCarthy Integration of Genomic and Other Epidemiologic Data to Investigate and Control a Cross-Institutional Outbreak of Streptococcus pyogenes Emerging Infectious Diseases Group A Streptococcus invasive group A streptococcal infection iGAS outbreak genome infection control |
| title | Integration of Genomic and Other Epidemiologic Data to Investigate and Control a Cross-Institutional Outbreak of Streptococcus pyogenes |
| title_full | Integration of Genomic and Other Epidemiologic Data to Investigate and Control a Cross-Institutional Outbreak of Streptococcus pyogenes |
| title_fullStr | Integration of Genomic and Other Epidemiologic Data to Investigate and Control a Cross-Institutional Outbreak of Streptococcus pyogenes |
| title_full_unstemmed | Integration of Genomic and Other Epidemiologic Data to Investigate and Control a Cross-Institutional Outbreak of Streptococcus pyogenes |
| title_short | Integration of Genomic and Other Epidemiologic Data to Investigate and Control a Cross-Institutional Outbreak of Streptococcus pyogenes |
| title_sort | integration of genomic and other epidemiologic data to investigate and control a cross institutional outbreak of streptococcus pyogenes |
| topic | Group A Streptococcus invasive group A streptococcal infection iGAS outbreak genome infection control |
| url | https://wwwnc.cdc.gov/eid/article/22/6/14-2050_article |
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