Effects of the Olive-Derived Polyphenol Oleuropein on Human Health
The use of the products derived from the olive tree on human health dates back centuries. In several civilizations, the olive tree had and still has a very strong cultural and religious symbolism. Notably, the official seal and emblem of the World Health Organization features the rod of Asclepius o...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2014-10-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | http://www.mdpi.com/1422-0067/15/10/18508 |
| _version_ | 1811192557356449792 |
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| author | Barbara Barbaro Gabriele Toietta Roberta Maggio Mario Arciello Mirko Tarocchi Andrea Galli Clara Balsano |
| author_facet | Barbara Barbaro Gabriele Toietta Roberta Maggio Mario Arciello Mirko Tarocchi Andrea Galli Clara Balsano |
| author_sort | Barbara Barbaro |
| collection | DOAJ |
| description | The use of the products derived from the olive tree on human health dates back centuries. In several civilizations, the olive tree had and still has a very strong cultural and religious symbolism. Notably, the official seal and emblem of the World Health Organization features the rod of Asclepius over a world map surrounded by olive tree branches, chosen as a symbol of peace and health. Recently, accumulating experimental, clinical and epidemiological data have provided support to the traditional beliefs of the beneficial effect provided by olive derivates. In particular, the polyphenols present in olive leaves, olives, virgin (unrefined) olive oil and olive mill waste are potent antioxidant and radical scavengers with anti-tumor and anti-inflammatory properties. Here, we review the positive impact on human health of oleuropein, the most prevalent polyphenol present in olives. In addition, we provide data collected in our laboratory on the role of oleuropein in counteracting lipid accumulation in a mouse model of non-alcoholic fatty liver disease. |
| first_indexed | 2024-04-11T23:54:35Z |
| format | Article |
| id | doaj.art-e9d3b85a36464b11bd17edc4fe7577d2 |
| institution | Directory Open Access Journal |
| issn | 1422-0067 |
| language | English |
| last_indexed | 2024-04-11T23:54:35Z |
| publishDate | 2014-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-e9d3b85a36464b11bd17edc4fe7577d22022-12-22T03:56:24ZengMDPI AGInternational Journal of Molecular Sciences1422-00672014-10-011510185081852410.3390/ijms151018508ijms151018508Effects of the Olive-Derived Polyphenol Oleuropein on Human HealthBarbara Barbaro0Gabriele Toietta1Roberta Maggio2Mario Arciello3Mirko Tarocchi4Andrea Galli5Clara Balsano6Laboratory of Molecular Virology and Oncology, Francesco Balsano Foundation, Rome 00198, ItalyDepartment of Experimental Oncology, Regina Elena National Cancer Institute IRCCS, Rome 00144, ItalyLaboratory of Molecular Virology and Oncology, Francesco Balsano Foundation, Rome 00198, ItalyLaboratory of Molecular Virology and Oncology, Francesco Balsano Foundation, Rome 00198, ItalyDepartment of Experimental and Clinical Biomedical Sciences, University of Florence, Florence 50139, ItalyDepartment of Experimental and Clinical Biomedical Sciences, University of Florence, Florence 50139, ItalyInstitute of Biology, Molecular Medicine and Nanobiotechnologies (IBMN), National Research Council (CNR), Rome 00185, ItalyThe use of the products derived from the olive tree on human health dates back centuries. In several civilizations, the olive tree had and still has a very strong cultural and religious symbolism. Notably, the official seal and emblem of the World Health Organization features the rod of Asclepius over a world map surrounded by olive tree branches, chosen as a symbol of peace and health. Recently, accumulating experimental, clinical and epidemiological data have provided support to the traditional beliefs of the beneficial effect provided by olive derivates. In particular, the polyphenols present in olive leaves, olives, virgin (unrefined) olive oil and olive mill waste are potent antioxidant and radical scavengers with anti-tumor and anti-inflammatory properties. Here, we review the positive impact on human health of oleuropein, the most prevalent polyphenol present in olives. In addition, we provide data collected in our laboratory on the role of oleuropein in counteracting lipid accumulation in a mouse model of non-alcoholic fatty liver disease.http://www.mdpi.com/1422-0067/15/10/18508oliveoleuropeinMediterranean dietpolyphenolsantioxidantanti-inflammatoryanticancernon-alcoholic fatty liver disease |
| spellingShingle | Barbara Barbaro Gabriele Toietta Roberta Maggio Mario Arciello Mirko Tarocchi Andrea Galli Clara Balsano Effects of the Olive-Derived Polyphenol Oleuropein on Human Health International Journal of Molecular Sciences olive oleuropein Mediterranean diet polyphenols antioxidant anti-inflammatory anticancer non-alcoholic fatty liver disease |
| title | Effects of the Olive-Derived Polyphenol Oleuropein on Human Health |
| title_full | Effects of the Olive-Derived Polyphenol Oleuropein on Human Health |
| title_fullStr | Effects of the Olive-Derived Polyphenol Oleuropein on Human Health |
| title_full_unstemmed | Effects of the Olive-Derived Polyphenol Oleuropein on Human Health |
| title_short | Effects of the Olive-Derived Polyphenol Oleuropein on Human Health |
| title_sort | effects of the olive derived polyphenol oleuropein on human health |
| topic | olive oleuropein Mediterranean diet polyphenols antioxidant anti-inflammatory anticancer non-alcoholic fatty liver disease |
| url | http://www.mdpi.com/1422-0067/15/10/18508 |
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