Micro lesion effect of pallidal deep‑brain stimulation for meige syndrome
Abstract To analyse the microlesion effect (MLE) in the globus pallidus interna (GPi) of deep brain stimulation (DBS) in patients with Meige syndrome. Thirty-two patients with primary Meige syndrome who underwent GPi-DBS in this study. Burke–Fahn–Marsden Dystonia Rating Scale scores (BFMDRS-M) were...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-11-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-23156-2 |
| _version_ | 1811210806628450304 |
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| author | Jiayu Liu Hu Ding Ke Xu Dongliang Wang Jia Ouyang Zhi Liu Ruen Liu |
| author_facet | Jiayu Liu Hu Ding Ke Xu Dongliang Wang Jia Ouyang Zhi Liu Ruen Liu |
| author_sort | Jiayu Liu |
| collection | DOAJ |
| description | Abstract To analyse the microlesion effect (MLE) in the globus pallidus interna (GPi) of deep brain stimulation (DBS) in patients with Meige syndrome. Thirty-two patients with primary Meige syndrome who underwent GPi-DBS in this study. Burke–Fahn–Marsden Dystonia Rating Scale scores (BFMDRS-M) were obtained for the evaluation of clinical symptoms at 3 days before DBS (baseline), 24 h after DBS surgery, once weekly for 1 month until electrical stimulation, 6 months postoperatively and 12 months after surgery. Twenty-seven patients had MLE after GPi-DBS. The mean time of BFMDRS-M scores maximal improvement from MLE was 35.9 h postoperatively (range, 24–48 h), and the mean scores improved by 49.35 ± 18.16%. At 12 months after surgery, the mean BFMDRS-M scores improved by 50.28 ± 29.70%. There was a positive correlation between the magnitude of MLE and the motor score at 12 months after GPi-DBS (R2 = 0.335, p < 0.05). However, there was no correlation between the duration of MLE and DBS improvement. Most Meige syndrome patients who underwent GPi-DBS and had MLE benefited from MLE. For Meige syndrome, MLE might be a predictive factor for patient clinical symptom improvement from DBS. |
| first_indexed | 2024-04-12T05:01:54Z |
| format | Article |
| id | doaj.art-e9d42219a18643f491288db8a4215755 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-12T05:01:54Z |
| publishDate | 2022-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-e9d42219a18643f491288db8a42157552022-12-22T03:46:58ZengNature PortfolioScientific Reports2045-23222022-11-011211710.1038/s41598-022-23156-2Micro lesion effect of pallidal deep‑brain stimulation for meige syndromeJiayu Liu0Hu Ding1Ke Xu2Dongliang Wang3Jia Ouyang4Zhi Liu5Ruen Liu6Department of Neurosurgery, Peking University People’s HospitalDepartment of Neurosurgery, Peking University People’s HospitalDepartment of Neurosurgery, Peking University People’s HospitalDepartment of Neurosurgery, Peking University People’s HospitalDepartment of Neurosurgery, Peking University People’s HospitalDepartment of Neurosurgery, Peking University People’s HospitalDepartment of Neurosurgery, Peking University People’s HospitalAbstract To analyse the microlesion effect (MLE) in the globus pallidus interna (GPi) of deep brain stimulation (DBS) in patients with Meige syndrome. Thirty-two patients with primary Meige syndrome who underwent GPi-DBS in this study. Burke–Fahn–Marsden Dystonia Rating Scale scores (BFMDRS-M) were obtained for the evaluation of clinical symptoms at 3 days before DBS (baseline), 24 h after DBS surgery, once weekly for 1 month until electrical stimulation, 6 months postoperatively and 12 months after surgery. Twenty-seven patients had MLE after GPi-DBS. The mean time of BFMDRS-M scores maximal improvement from MLE was 35.9 h postoperatively (range, 24–48 h), and the mean scores improved by 49.35 ± 18.16%. At 12 months after surgery, the mean BFMDRS-M scores improved by 50.28 ± 29.70%. There was a positive correlation between the magnitude of MLE and the motor score at 12 months after GPi-DBS (R2 = 0.335, p < 0.05). However, there was no correlation between the duration of MLE and DBS improvement. Most Meige syndrome patients who underwent GPi-DBS and had MLE benefited from MLE. For Meige syndrome, MLE might be a predictive factor for patient clinical symptom improvement from DBS.https://doi.org/10.1038/s41598-022-23156-2 |
| spellingShingle | Jiayu Liu Hu Ding Ke Xu Dongliang Wang Jia Ouyang Zhi Liu Ruen Liu Micro lesion effect of pallidal deep‑brain stimulation for meige syndrome Scientific Reports |
| title | Micro lesion effect of pallidal deep‑brain stimulation for meige syndrome |
| title_full | Micro lesion effect of pallidal deep‑brain stimulation for meige syndrome |
| title_fullStr | Micro lesion effect of pallidal deep‑brain stimulation for meige syndrome |
| title_full_unstemmed | Micro lesion effect of pallidal deep‑brain stimulation for meige syndrome |
| title_short | Micro lesion effect of pallidal deep‑brain stimulation for meige syndrome |
| title_sort | micro lesion effect of pallidal deep brain stimulation for meige syndrome |
| url | https://doi.org/10.1038/s41598-022-23156-2 |
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