Effects of glargine on hyperglycemia in patients with diabetes mellitus type II undergoing off-pump coronary artery bypass graft: A randomized, controlled, double-blind clinical trial
Introduction: In this trial, effects of glargine on hyperglycemia in patients with diabetes mellitus type II who were undergoing off-pump coronary artery bypass graft (CAGB), were examined. Methods: Seventy diabetic patients who were candidate for off-pump CABG were randomly divided into the followi...
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| Format: | Article |
| Language: | English |
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Tabriz University of Medical Sciences
2023-03-01
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| Series: | Journal of Cardiovascular and Thoracic Research |
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| Online Access: | https://jcvtr.tbzmed.ac.ir/PDF/jcvtr-15-44.pdf |
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| author | Shima Sheybani Mahdi Kahrom Raheleh Ganjali Seyedeh Mahsa Kalati Nahid Zirak Vahideh Ghorani |
| author_facet | Shima Sheybani Mahdi Kahrom Raheleh Ganjali Seyedeh Mahsa Kalati Nahid Zirak Vahideh Ghorani |
| author_sort | Shima Sheybani |
| collection | DOAJ |
| description | Introduction: In this trial, effects of glargine on hyperglycemia in patients with diabetes mellitus type II who were undergoing off-pump coronary artery bypass graft (CAGB), were examined. Methods: Seventy diabetic patients who were candidate for off-pump CABG were randomly divided into the following two groups (1) Control group who were treated with normal saline+regular insulin and (2) Glargine group who received glargine+regular insulin. Normal saline and glargine were administered subcutaneously 2 hours before surgery, and regular insulin was injected before, during and after the surgery in the intensive care unit (ICU) in both groups. Finally, levels of blood sugar before, 2 hours after starting the surgery and at the end of the surgery, were recorded. Blood sugar levels during ICU stay were also measured every 4 hours for 36 hours. Results: There were no significant differences in blood sugar levels between the groups at the three time points (i.e. before, 2 hours after starting the surgery and at the end of the surgery). In addition, during 36 hours of ICU stay, blood sugar levels did not show significant variations between the groups; however, 20 hours after ICU admission, blood sugar level was significantly higher in the glargine group (P=0.04). Conclusion: The results indicated that both glargine and regular insulin effectively control the blood glucose in diabetic patients undergoing CABG. However, the blood sugar fluctuation was less in the glargine group than control group. |
| first_indexed | 2024-03-13T05:53:22Z |
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| id | doaj.art-e9d4f9ab29e64209b8c62fe28e2b1974 |
| institution | Directory Open Access Journal |
| issn | 2008-5117 2008-6830 |
| language | English |
| last_indexed | 2024-03-13T05:53:22Z |
| publishDate | 2023-03-01 |
| publisher | Tabriz University of Medical Sciences |
| record_format | Article |
| series | Journal of Cardiovascular and Thoracic Research |
| spelling | doaj.art-e9d4f9ab29e64209b8c62fe28e2b19742023-06-13T08:29:35ZengTabriz University of Medical SciencesJournal of Cardiovascular and Thoracic Research2008-51172008-68302023-03-01151445010.34172/jcvtr.2023.31596jcvtr-31596Effects of glargine on hyperglycemia in patients with diabetes mellitus type II undergoing off-pump coronary artery bypass graft: A randomized, controlled, double-blind clinical trialShima Sheybani0Mahdi Kahrom1Raheleh Ganjali2Seyedeh Mahsa Kalati3Nahid Zirak4Vahideh Ghorani5Department of Anesthesiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Cardiovascular Surgery, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranClinical Research Development Unit, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Anesthesiology, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Anesthesiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranClinical Research Development Unit, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranIntroduction: In this trial, effects of glargine on hyperglycemia in patients with diabetes mellitus type II who were undergoing off-pump coronary artery bypass graft (CAGB), were examined. Methods: Seventy diabetic patients who were candidate for off-pump CABG were randomly divided into the following two groups (1) Control group who were treated with normal saline+regular insulin and (2) Glargine group who received glargine+regular insulin. Normal saline and glargine were administered subcutaneously 2 hours before surgery, and regular insulin was injected before, during and after the surgery in the intensive care unit (ICU) in both groups. Finally, levels of blood sugar before, 2 hours after starting the surgery and at the end of the surgery, were recorded. Blood sugar levels during ICU stay were also measured every 4 hours for 36 hours. Results: There were no significant differences in blood sugar levels between the groups at the three time points (i.e. before, 2 hours after starting the surgery and at the end of the surgery). In addition, during 36 hours of ICU stay, blood sugar levels did not show significant variations between the groups; however, 20 hours after ICU admission, blood sugar level was significantly higher in the glargine group (P=0.04). Conclusion: The results indicated that both glargine and regular insulin effectively control the blood glucose in diabetic patients undergoing CABG. However, the blood sugar fluctuation was less in the glargine group than control group.https://jcvtr.tbzmed.ac.ir/PDF/jcvtr-15-44.pdfdiabetes mellitus type iiglargine insulincoronary artery bypass grafting |
| spellingShingle | Shima Sheybani Mahdi Kahrom Raheleh Ganjali Seyedeh Mahsa Kalati Nahid Zirak Vahideh Ghorani Effects of glargine on hyperglycemia in patients with diabetes mellitus type II undergoing off-pump coronary artery bypass graft: A randomized, controlled, double-blind clinical trial Journal of Cardiovascular and Thoracic Research diabetes mellitus type ii glargine insulin coronary artery bypass grafting |
| title | Effects of glargine on hyperglycemia in patients with diabetes mellitus type II undergoing off-pump coronary artery bypass graft: A randomized, controlled, double-blind clinical trial |
| title_full | Effects of glargine on hyperglycemia in patients with diabetes mellitus type II undergoing off-pump coronary artery bypass graft: A randomized, controlled, double-blind clinical trial |
| title_fullStr | Effects of glargine on hyperglycemia in patients with diabetes mellitus type II undergoing off-pump coronary artery bypass graft: A randomized, controlled, double-blind clinical trial |
| title_full_unstemmed | Effects of glargine on hyperglycemia in patients with diabetes mellitus type II undergoing off-pump coronary artery bypass graft: A randomized, controlled, double-blind clinical trial |
| title_short | Effects of glargine on hyperglycemia in patients with diabetes mellitus type II undergoing off-pump coronary artery bypass graft: A randomized, controlled, double-blind clinical trial |
| title_sort | effects of glargine on hyperglycemia in patients with diabetes mellitus type ii undergoing off pump coronary artery bypass graft a randomized controlled double blind clinical trial |
| topic | diabetes mellitus type ii glargine insulin coronary artery bypass grafting |
| url | https://jcvtr.tbzmed.ac.ir/PDF/jcvtr-15-44.pdf |
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