Comparison of visual outcomes between therapy choices and subtypes of polypoidal choroidal vasculopathy (PCV) in Taiwan: a real-world study
Abstract Polypoidal choroidal vasculopathy (PCV) is a distinctive type of neovascular age-related macular degeneration prevalent in many Asian countries. However, there is still some controversy in how the subtypes of PCV are classified. This post-hoc study redefined the branching vascular network (...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-01-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-020-80731-1 |
| _version_ | 1818682970826866688 |
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| author | Ling Yeung Chi-Chun Lai San-Ni Chen Cheng-Kuo Cheng Chung-May Yang Yi-Ting Hsieh Arslan Tsai Chang-Hao Yang |
| author_facet | Ling Yeung Chi-Chun Lai San-Ni Chen Cheng-Kuo Cheng Chung-May Yang Yi-Ting Hsieh Arslan Tsai Chang-Hao Yang |
| author_sort | Ling Yeung |
| collection | DOAJ |
| description | Abstract Polypoidal choroidal vasculopathy (PCV) is a distinctive type of neovascular age-related macular degeneration prevalent in many Asian countries. However, there is still some controversy in how the subtypes of PCV are classified. This post-hoc study redefined the branching vascular network (BVN) and PCV subtypes through retrospective review of indocyanine green angiography (ICGA) and fluorescein angiography images from two observational studies (RENOWNED/REAL). Of the visual outcomes for each angiographic subtype and treatment pattern investigated, BVN was identified in 56.3% of PCV patients. The proportions and features of the re-defined PCV subtypes were 43.8%, 10.4%, and 45.8% for subtype A (without distinctive features of BVN), B (with BVN but no leakage), and C (with BVN and leakage), respectively. Subtype A had better visual outcomes when compared to subtype C. This possibly resulted from a better baseline visual acuity in subtype A. Moreover, combination therapy [photodynamic therapy plus anti-vascular endothelial growth factor (VEGF)] may lead to better visual improvement than mono-anti-VEGF treatment alone. This study provides the prevalence of PCV subtypes in Taiwan and may serve as a reference for PCV treatment strategies in a real-world setting, especially for the combination therapy and patients without distinctive features of BVN. |
| first_indexed | 2024-12-17T10:27:18Z |
| format | Article |
| id | doaj.art-e9d5bca02b8c40ecb7b9b5a7a841f401 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-17T10:27:18Z |
| publishDate | 2021-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-e9d5bca02b8c40ecb7b9b5a7a841f4012022-12-21T21:52:37ZengNature PortfolioScientific Reports2045-23222021-01-011111810.1038/s41598-020-80731-1Comparison of visual outcomes between therapy choices and subtypes of polypoidal choroidal vasculopathy (PCV) in Taiwan: a real-world studyLing Yeung0Chi-Chun Lai1San-Ni Chen2Cheng-Kuo Cheng3Chung-May Yang4Yi-Ting Hsieh5Arslan Tsai6Chang-Hao Yang7Department of Ophthalmology, Chang Gung Memorial HospitalDepartment of Ophthalmology, Chang Gung Memorial HospitalDepartment of Ophthalmology, Changhua Christian HospitalDepartment of Ophthalmology, Shin Kong Wu Ho-Su Memorial HospitalDepartment of Ophthalmology, School of Medicine, National Taiwan University HospitalDepartment of Ophthalmology, School of Medicine, National Taiwan University HospitalClinical Development and Medical Affairs, Novartis TaiwanDepartment of Ophthalmology, School of Medicine, National Taiwan University HospitalAbstract Polypoidal choroidal vasculopathy (PCV) is a distinctive type of neovascular age-related macular degeneration prevalent in many Asian countries. However, there is still some controversy in how the subtypes of PCV are classified. This post-hoc study redefined the branching vascular network (BVN) and PCV subtypes through retrospective review of indocyanine green angiography (ICGA) and fluorescein angiography images from two observational studies (RENOWNED/REAL). Of the visual outcomes for each angiographic subtype and treatment pattern investigated, BVN was identified in 56.3% of PCV patients. The proportions and features of the re-defined PCV subtypes were 43.8%, 10.4%, and 45.8% for subtype A (without distinctive features of BVN), B (with BVN but no leakage), and C (with BVN and leakage), respectively. Subtype A had better visual outcomes when compared to subtype C. This possibly resulted from a better baseline visual acuity in subtype A. Moreover, combination therapy [photodynamic therapy plus anti-vascular endothelial growth factor (VEGF)] may lead to better visual improvement than mono-anti-VEGF treatment alone. This study provides the prevalence of PCV subtypes in Taiwan and may serve as a reference for PCV treatment strategies in a real-world setting, especially for the combination therapy and patients without distinctive features of BVN.https://doi.org/10.1038/s41598-020-80731-1 |
| spellingShingle | Ling Yeung Chi-Chun Lai San-Ni Chen Cheng-Kuo Cheng Chung-May Yang Yi-Ting Hsieh Arslan Tsai Chang-Hao Yang Comparison of visual outcomes between therapy choices and subtypes of polypoidal choroidal vasculopathy (PCV) in Taiwan: a real-world study Scientific Reports |
| title | Comparison of visual outcomes between therapy choices and subtypes of polypoidal choroidal vasculopathy (PCV) in Taiwan: a real-world study |
| title_full | Comparison of visual outcomes between therapy choices and subtypes of polypoidal choroidal vasculopathy (PCV) in Taiwan: a real-world study |
| title_fullStr | Comparison of visual outcomes between therapy choices and subtypes of polypoidal choroidal vasculopathy (PCV) in Taiwan: a real-world study |
| title_full_unstemmed | Comparison of visual outcomes between therapy choices and subtypes of polypoidal choroidal vasculopathy (PCV) in Taiwan: a real-world study |
| title_short | Comparison of visual outcomes between therapy choices and subtypes of polypoidal choroidal vasculopathy (PCV) in Taiwan: a real-world study |
| title_sort | comparison of visual outcomes between therapy choices and subtypes of polypoidal choroidal vasculopathy pcv in taiwan a real world study |
| url | https://doi.org/10.1038/s41598-020-80731-1 |
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