Propafenone effect on inotropic myocardial function in patients with recurrent atral fibrillation
Aim. To study the effects of three-month propafenone antiarrhythmic therapy (daily dose 450 mg) on inotropic myocardial function in patients with recurrent atrial fibrillation (AF). Material and methods. The study included 18 (100%) patients aged 39-59 years (mean age 51.7±6.7 years), receiving prop...
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| Format: | Article |
| Language: | Russian |
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«SILICEA-POLIGRAF» LLC
2006-06-01
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| Series: | Кардиоваскулярная терапия и профилактика |
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| Online Access: | https://cardiovascular.elpub.ru/jour/article/view/1199 |
| _version_ | 1797882774115319808 |
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| author | I. G. Fomina A. I. Tarzimanova A. V. Vetluzhsky |
| author_facet | I. G. Fomina A. I. Tarzimanova A. V. Vetluzhsky |
| author_sort | I. G. Fomina |
| collection | DOAJ |
| description | Aim. To study the effects of three-month propafenone antiarrhythmic therapy (daily dose 450 mg) on inotropic myocardial function in patients with recurrent atrial fibrillation (AF). Material and methods. The study included 18 (100%) patients aged 39-59 years (mean age 51.7±6.7 years), receiving propafenone (450 mg/d) for 3 months, to prevent recurrent AF. To assess antiarrhythmic therapy effects on inotropic myocardial function, all participants underwent balanced radionuclide ventriculography at baseline; in patients with maintained sinus rhythm, it was repeated after 3 months of treatment. Results. In first 3 days after restoring sinus rhythm in recurrent AF patients, diastolic function dynamics was observed: significant reduction in 1/3 diastole filling and peak filling velocity. After 3 months of propafenone treatment, left ventricular (LF) 1/3 diastole filling (p<0.05), as well as LV and right ventricular (RV) filling peak velocity (p<0.05), significantly increased. Ejection fraction, systolic and volumic parameters of LV and RV stayed within the normal range and did not change significantly. After 3-month propafenone therapy, recurrent AF patients demonstrated significant increase in atrial input into LV diastole – from 17.1±5.7% to 22.1±6.5%, and RV diastole – from 17.3±5.1% to 21.1±6.2% (р<0.05). Conclusion. Propafenone therapy (450 mg/d) facilitated 3-month sinus rhythm maintenance in 77% patients with recurrent AF. The therapy did not affect LF and RV inotropic myocardial function. Maintaining sinus rhythm for 3 moths facilitated normalization of atrial contractility and ventricular diastolic dysfunction improvement. |
| first_indexed | 2024-04-10T03:41:05Z |
| format | Article |
| id | doaj.art-e9d632d0fac54459b1ded7564d320253 |
| institution | Directory Open Access Journal |
| issn | 1728-8800 2619-0125 |
| language | Russian |
| last_indexed | 2024-04-10T03:41:05Z |
| publishDate | 2006-06-01 |
| publisher | «SILICEA-POLIGRAF» LLC |
| record_format | Article |
| series | Кардиоваскулярная терапия и профилактика |
| spelling | doaj.art-e9d632d0fac54459b1ded7564d3202532023-03-13T07:23:12Zrus«SILICEA-POLIGRAF» LLCКардиоваскулярная терапия и профилактика1728-88002619-01252006-06-01534954911Propafenone effect on inotropic myocardial function in patients with recurrent atral fibrillationI. G. Fomina0A. I. Tarzimanova1A. V. Vetluzhsky2Московская медицинская академия им. И.М.Сеченова на базе ГКБ № 61. МоскваМосковская медицинская академия им. И.М.Сеченова на базе ГКБ № 61. МоскваМосковская медицинская академия им. И.М.Сеченова на базе ГКБ № 61. МоскваAim. To study the effects of three-month propafenone antiarrhythmic therapy (daily dose 450 mg) on inotropic myocardial function in patients with recurrent atrial fibrillation (AF). Material and methods. The study included 18 (100%) patients aged 39-59 years (mean age 51.7±6.7 years), receiving propafenone (450 mg/d) for 3 months, to prevent recurrent AF. To assess antiarrhythmic therapy effects on inotropic myocardial function, all participants underwent balanced radionuclide ventriculography at baseline; in patients with maintained sinus rhythm, it was repeated after 3 months of treatment. Results. In first 3 days after restoring sinus rhythm in recurrent AF patients, diastolic function dynamics was observed: significant reduction in 1/3 diastole filling and peak filling velocity. After 3 months of propafenone treatment, left ventricular (LF) 1/3 diastole filling (p<0.05), as well as LV and right ventricular (RV) filling peak velocity (p<0.05), significantly increased. Ejection fraction, systolic and volumic parameters of LV and RV stayed within the normal range and did not change significantly. After 3-month propafenone therapy, recurrent AF patients demonstrated significant increase in atrial input into LV diastole – from 17.1±5.7% to 22.1±6.5%, and RV diastole – from 17.3±5.1% to 21.1±6.2% (р<0.05). Conclusion. Propafenone therapy (450 mg/d) facilitated 3-month sinus rhythm maintenance in 77% patients with recurrent AF. The therapy did not affect LF and RV inotropic myocardial function. Maintaining sinus rhythm for 3 moths facilitated normalization of atrial contractility and ventricular diastolic dysfunction improvement.https://cardiovascular.elpub.ru/jour/article/view/1199фибрилляция предсердийпропафенонинотропная функция сердцаремоделирование предсердий |
| spellingShingle | I. G. Fomina A. I. Tarzimanova A. V. Vetluzhsky Propafenone effect on inotropic myocardial function in patients with recurrent atral fibrillation Кардиоваскулярная терапия и профилактика фибрилляция предсердий пропафенон инотропная функция сердца ремоделирование предсердий |
| title | Propafenone effect on inotropic myocardial function in patients with recurrent atral fibrillation |
| title_full | Propafenone effect on inotropic myocardial function in patients with recurrent atral fibrillation |
| title_fullStr | Propafenone effect on inotropic myocardial function in patients with recurrent atral fibrillation |
| title_full_unstemmed | Propafenone effect on inotropic myocardial function in patients with recurrent atral fibrillation |
| title_short | Propafenone effect on inotropic myocardial function in patients with recurrent atral fibrillation |
| title_sort | propafenone effect on inotropic myocardial function in patients with recurrent atral fibrillation |
| topic | фибрилляция предсердий пропафенон инотропная функция сердца ремоделирование предсердий |
| url | https://cardiovascular.elpub.ru/jour/article/view/1199 |
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