| Summary: | Abstract Background and Aims Psychological, behavioral, hormonal, surgical, and psychopharmacologic approaches are the only acknowledged treatments for Female Sexual Dysfunction (FSD). The study is conducted to assess the efficacy of hybrid cooperative complexes of high and low molecular weight hyaluronan (hybrid H‐HA/L‐HA) in treating females with varying of sexual dysfunction and to assess the female genital self‐image scale (FGSIS), female sexual function index (FSFI), and dermatology life quality index (DLQI) before and after treatment. Methods Sixty female patients were divided into two groups. The study group enrolled 30 female patients injected with hybrid H‐HA/L‐HA, while the control group enrolled 30 female patients injected with saline. Patients were recruited from the clinic searching for medical advice. Controls were selected from close associates of the cases who were attending with the patients or healthy escorts of dermatology patients attending the dermatology outpatient clinic. We assessed socio‐demographic, clinical evaluation, the (FGSIS), (FSFI), and (DLQI) before and after treatment. The first assessment was conducted at the first visit, and the second assessment was conducted after 1 month of the second injection. Result Significant increase in the frequency of sexual intercourse/week in the study group after the first and second injection sessions compared to the controls was observed (p < 0.05). There was statistically significant amelioration in desire, arousal, lubrication, orgasm, satisfaction domains, and total score of the FSFI (p ≤ 0.05). The study demonstrated significant increasing differences in all domains of the FGSIS (p ≤ 0.05). The symptoms and feelings, leisure, personal relationships, and total scores were significantly higher post first and second injection of (hybrid H‐HA/L‐HA) sessions compared to the controls (p < 0.05). Conclusion The (hybrid H‐HA/L‐HA) injection for rejuvenating the genital area appears to be a safe and effective way to enhance female genital self‐image, sexuality, and quality of life with high levels of satisfaction as a minimally invasive method.
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