Two‐ and three‐piece implants to boost data generation in preclinical in vivo research—A short technical report
Abstract The purpose of this technical report is to present two novel experimental implant designs to boost data generation in preclinical in vivo research. Specifically, the report describes the rationale and the components of (1) a two‐piece experimental implant suitable for a small animal platfor...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-12-01
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| Series: | Clinical and Experimental Dental Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/cre2.805 |
| _version_ | 1797386603632525312 |
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| author | Andreas Stavropoulos Benjamin Bellon Benjamin Pipenger Ole Z. Andersen |
| author_facet | Andreas Stavropoulos Benjamin Bellon Benjamin Pipenger Ole Z. Andersen |
| author_sort | Andreas Stavropoulos |
| collection | DOAJ |
| description | Abstract The purpose of this technical report is to present two novel experimental implant designs to boost data generation in preclinical in vivo research. Specifically, the report describes the rationale and the components of (1) a two‐piece experimental implant suitable for a small animal platform (e.g., the rabbit femur/tibial epiphysis model), consisting of a threaded apical‐ and a coronal cylindrical piece, which is intended for collecting two types of biomechanical data, and (2) a three‐piece experimental implant suitable for a large animal platform (e.g., the mini‐pig mandible model), consisting of an apical “wound chamber”, which allows the collection of histological/histomorphometrical data, and a middle threaded and coronal cylindrical piece, which also allow the collection of two types of biomechanical data. The increased volume of information generated from a single experiment in a small animal platform, using the proposed two‐piece implant design, may assist in a more qualified decision‐making process, on whether it is relevant to proceed to further assessment using a large animal platform. Furthermore, the increased volume of information generated in a single animal experiment either in a small or large animal platform, using the proposed two‐ and three‐piece implants, respectively, likely decreases the number of animals otherwise needed for collecting the same information with standard one‐piece implants and, thus, contributes to the reduction/refinement elements of the 3R principle. |
| first_indexed | 2024-03-08T22:12:49Z |
| format | Article |
| id | doaj.art-e9d6f1caafcd45de8949239d49c8706e |
| institution | Directory Open Access Journal |
| issn | 2057-4347 |
| language | English |
| last_indexed | 2024-03-08T22:12:49Z |
| publishDate | 2023-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Experimental Dental Research |
| spelling | doaj.art-e9d6f1caafcd45de8949239d49c8706e2023-12-19T05:49:29ZengWileyClinical and Experimental Dental Research2057-43472023-12-01961004100810.1002/cre2.805Two‐ and three‐piece implants to boost data generation in preclinical in vivo research—A short technical reportAndreas Stavropoulos0Benjamin Bellon1Benjamin Pipenger2Ole Z. Andersen3Department of Periodontology, Faculty of Odontology Malmö University Malmö SwedenDepartment of Periodontology, Faculty of Dentistry University of Zurich Zurich SwitzerlandDepartment of Periodontology, School of Dental Medicine University of Bern Bern SwitzerlandDepartment of Periodontology, School of Dental Medicine University of Bern Bern SwitzerlandAbstract The purpose of this technical report is to present two novel experimental implant designs to boost data generation in preclinical in vivo research. Specifically, the report describes the rationale and the components of (1) a two‐piece experimental implant suitable for a small animal platform (e.g., the rabbit femur/tibial epiphysis model), consisting of a threaded apical‐ and a coronal cylindrical piece, which is intended for collecting two types of biomechanical data, and (2) a three‐piece experimental implant suitable for a large animal platform (e.g., the mini‐pig mandible model), consisting of an apical “wound chamber”, which allows the collection of histological/histomorphometrical data, and a middle threaded and coronal cylindrical piece, which also allow the collection of two types of biomechanical data. The increased volume of information generated from a single experiment in a small animal platform, using the proposed two‐piece implant design, may assist in a more qualified decision‐making process, on whether it is relevant to proceed to further assessment using a large animal platform. Furthermore, the increased volume of information generated in a single animal experiment either in a small or large animal platform, using the proposed two‐ and three‐piece implants, respectively, likely decreases the number of animals otherwise needed for collecting the same information with standard one‐piece implants and, thus, contributes to the reduction/refinement elements of the 3R principle.https://doi.org/10.1002/cre2.805biomechanicalhistologyimplantspreclinical |
| spellingShingle | Andreas Stavropoulos Benjamin Bellon Benjamin Pipenger Ole Z. Andersen Two‐ and three‐piece implants to boost data generation in preclinical in vivo research—A short technical report Clinical and Experimental Dental Research biomechanical histology implants preclinical |
| title | Two‐ and three‐piece implants to boost data generation in preclinical in vivo research—A short technical report |
| title_full | Two‐ and three‐piece implants to boost data generation in preclinical in vivo research—A short technical report |
| title_fullStr | Two‐ and three‐piece implants to boost data generation in preclinical in vivo research—A short technical report |
| title_full_unstemmed | Two‐ and three‐piece implants to boost data generation in preclinical in vivo research—A short technical report |
| title_short | Two‐ and three‐piece implants to boost data generation in preclinical in vivo research—A short technical report |
| title_sort | two and three piece implants to boost data generation in preclinical in vivo research a short technical report |
| topic | biomechanical histology implants preclinical |
| url | https://doi.org/10.1002/cre2.805 |
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