A Dynamic Interplay of Circulating Extracellular Vesicles and Galectin-1 Reprograms Viral Latency during HIV-1 Infection

A Dynamic Interplay of Circulating Extracellular Vesicles and Galectin-1 Reprograms Viral Latency during HIV-1 Infection

ABSTRACT Combined Antiretroviral therapy (cART) suppresses HIV replication but fails to eradicate the virus, which persists in a small pool of long-lived latently infected cells. Immune activation and residual inflammation during cART are considered to contribute to viral persistence. Galectins, a f...

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Bibliografiska uppgifter
Huvudupphovsmän: Julia Rubione, Paula S. Pérez, Alejandro Czernikier, Gabriel A. Duette, Federico Pehuen Pereyra Gerber, Jimena Salido, Martina P. Fabiano, Yanina Ghiglione, Gabriela Turk, Natalia Laufer, Alejandro J. Cagnoni, Juan M. Pérez Sáez, Joaquín P. Merlo, Carla Pascuale, Juan C. Stupirski, Omar Sued, Manuel Varas-Godoy, Sharon R. Lewin, Karina V. Mariño, Gabriel A. Rabinovich, Matías Ostrowski
Materialtyp: Artikel
Språk:English
Publicerad: American Society for Microbiology 2022-08-01
Serie:mBio
Ämnen:
galectin-1
human immunodeficiency virus
extracellular vesicles
viral reservoir
chronic inflammation
Länkar:https://journals.asm.org/doi/10.1128/mbio.00611-22

Internet

https://journals.asm.org/doi/10.1128/mbio.00611-22

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