A Dynamic Interplay of Circulating Extracellular Vesicles and Galectin-1 Reprograms Viral Latency during HIV-1 Infection

A Dynamic Interplay of Circulating Extracellular Vesicles and Galectin-1 Reprograms Viral Latency during HIV-1 Infection

ABSTRACT Combined Antiretroviral therapy (cART) suppresses HIV replication but fails to eradicate the virus, which persists in a small pool of long-lived latently infected cells. Immune activation and residual inflammation during cART are considered to contribute to viral persistence. Galectins, a f...

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Bibliographic Details
Main Authors: Julia Rubione, Paula S. Pérez, Alejandro Czernikier, Gabriel A. Duette, Federico Pehuen Pereyra Gerber, Jimena Salido, Martina P. Fabiano, Yanina Ghiglione, Gabriela Turk, Natalia Laufer, Alejandro J. Cagnoni, Juan M. Pérez Sáez, Joaquín P. Merlo, Carla Pascuale, Juan C. Stupirski, Omar Sued, Manuel Varas-Godoy, Sharon R. Lewin, Karina V. Mariño, Gabriel A. Rabinovich, Matías Ostrowski
Format: Article
Language:English
Published: American Society for Microbiology 2022-08-01
Series:mBio
Subjects:
galectin-1
human immunodeficiency virus
extracellular vesicles
viral reservoir
chronic inflammation
Online Access:https://journals.asm.org/doi/10.1128/mbio.00611-22

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