A TFEB nuclear export signal integrates amino acid supply and glucose availability
On amino acid deprivation TFEB translocates from the cytoplasm to the nucleus. Here the authors identify a nuclear export signal in TFEB that requires dual phosphorylation at the S142 ERK/mTORC1 and S138 GSK3β sites, and further show glucose limitation drives nuclear accumulation of TFEB and inhibit...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2018-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-04849-7 |
| _version_ | 1818991561519661056 |
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| author | Linxin Li Hans J. Friedrichsen Sarah Andrews Sarah Picaud Laurent Volpon Kaochin Ngeow Georgina Berridge Roman Fischer Katherine L. B. Borden Panagis Filippakopoulos Colin R. Goding |
| author_facet | Linxin Li Hans J. Friedrichsen Sarah Andrews Sarah Picaud Laurent Volpon Kaochin Ngeow Georgina Berridge Roman Fischer Katherine L. B. Borden Panagis Filippakopoulos Colin R. Goding |
| author_sort | Linxin Li |
| collection | DOAJ |
| description | On amino acid deprivation TFEB translocates from the cytoplasm to the nucleus. Here the authors identify a nuclear export signal in TFEB that requires dual phosphorylation at the S142 ERK/mTORC1 and S138 GSK3β sites, and further show glucose limitation drives nuclear accumulation of TFEB and inhibits GSK3β via an mTORC2-AKT dependent mechanism. |
| first_indexed | 2024-12-20T20:12:13Z |
| format | Article |
| id | doaj.art-e9d8aa256d4f4d8c979b588562b4a5e7 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T20:12:13Z |
| publishDate | 2018-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-e9d8aa256d4f4d8c979b588562b4a5e72022-12-21T19:27:48ZengNature PortfolioNature Communications2041-17232018-07-019111510.1038/s41467-018-04849-7A TFEB nuclear export signal integrates amino acid supply and glucose availabilityLinxin Li0Hans J. Friedrichsen1Sarah Andrews2Sarah Picaud3Laurent Volpon4Kaochin Ngeow5Georgina Berridge6Roman Fischer7Katherine L. B. Borden8Panagis Filippakopoulos9Colin R. Goding10Ludwig Institute for Cancer Research, Nuffield Department of Clinical Medicine, University of OxfordLudwig Institute for Cancer Research, Nuffield Department of Clinical Medicine, University of OxfordLudwig Institute for Cancer Research, Nuffield Department of Clinical Medicine, University of OxfordStructural Genomics Consortium, Nuffield Department of Clinical Medicine, University of OxfordInstitute of Research in Immunology and Cancer (IRIC), Department of Pathology and Cell Biology, Université de Montréal, Pavillon Marcel-Coutou, Chemin de la PolytechniqueLudwig Institute for Cancer Research, Nuffield Department of Clinical Medicine, University of OxfordLudwig Institute for Cancer Research, Nuffield Department of Clinical Medicine, University of OxfordDiscovery Proteomics Facility, Target Discovery Institute, Nuffield Department of Clinical Medicine, University of OxfordInstitute of Research in Immunology and Cancer (IRIC), Department of Pathology and Cell Biology, Université de Montréal, Pavillon Marcel-Coutou, Chemin de la PolytechniqueLudwig Institute for Cancer Research, Nuffield Department of Clinical Medicine, University of OxfordLudwig Institute for Cancer Research, Nuffield Department of Clinical Medicine, University of OxfordOn amino acid deprivation TFEB translocates from the cytoplasm to the nucleus. Here the authors identify a nuclear export signal in TFEB that requires dual phosphorylation at the S142 ERK/mTORC1 and S138 GSK3β sites, and further show glucose limitation drives nuclear accumulation of TFEB and inhibits GSK3β via an mTORC2-AKT dependent mechanism.https://doi.org/10.1038/s41467-018-04849-7 |
| spellingShingle | Linxin Li Hans J. Friedrichsen Sarah Andrews Sarah Picaud Laurent Volpon Kaochin Ngeow Georgina Berridge Roman Fischer Katherine L. B. Borden Panagis Filippakopoulos Colin R. Goding A TFEB nuclear export signal integrates amino acid supply and glucose availability Nature Communications |
| title | A TFEB nuclear export signal integrates amino acid supply and glucose availability |
| title_full | A TFEB nuclear export signal integrates amino acid supply and glucose availability |
| title_fullStr | A TFEB nuclear export signal integrates amino acid supply and glucose availability |
| title_full_unstemmed | A TFEB nuclear export signal integrates amino acid supply and glucose availability |
| title_short | A TFEB nuclear export signal integrates amino acid supply and glucose availability |
| title_sort | tfeb nuclear export signal integrates amino acid supply and glucose availability |
| url | https://doi.org/10.1038/s41467-018-04849-7 |
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