Chromatographically separable rotamers of an unhindered amide

Chromatographically separable rotamers of an unhindered amide

Surprisingly stable formamide rotamers were encountered in the tetrahydroisoquinoline and morphinan series of alkaloids. We investigated the hindered rotation around the amide bond by dynamic high-performance liquid chromatography (DHPLC) and kinetic measurements of the interconversion of the rotame...

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Bibliographic Details
Main Authors:	Mario Geffe, Lars Andernach, Oliver Trapp, Till Opatz
Format:	Article
Language:	English
Published:	Beilstein-Institut 2014-03-01
Series:	Beilstein Journal of Organic Chemistry
Subjects:	amides density functional calculations dynamic HPLC rotamers thermodynamics
Online Access:	https://doi.org/10.3762/bjoc.10.63

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