Nomograms to predict long‐term survival for patients with gallbladder carcinoma after resection
Abstract Background Surgical resection remains the primary treatment option for gallbladder carcinoma (GBC). However, there is a pressing demand for prognostic tools that can refine patients' treatment choices and tailor personalized therapies accordingly. Aims The nomograms were constructed us...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2024-03-01
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| Series: | Cancer Reports |
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| Online Access: | https://doi.org/10.1002/cnr2.1991 |
| _version_ | 1827303944565555200 |
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| author | Shilei Bai Pinghua Yang Jiliang Qiu Jie Wang Liu Liu Chunyan Wang Huifeng Wang Zhijian Wen Baohua Zhang |
| author_facet | Shilei Bai Pinghua Yang Jiliang Qiu Jie Wang Liu Liu Chunyan Wang Huifeng Wang Zhijian Wen Baohua Zhang |
| author_sort | Shilei Bai |
| collection | DOAJ |
| description | Abstract Background Surgical resection remains the primary treatment option for gallbladder carcinoma (GBC). However, there is a pressing demand for prognostic tools that can refine patients' treatment choices and tailor personalized therapies accordingly. Aims The nomograms were constructed using the data of a training cohort (n = 378) of GBC patients at Eastern Hepatobiliary Surgery Hospital (EHBH) between 2008 and 2018. The model's performance was validated in GBC patients (n = 108) at Guangzhou Centre from 2007 to 2018. Methods and results The 5‐year overall survival (OS) rate in the training cohort was 24.4%. Multivariate analyses were performed using preoperative and postoperative data to identify independent predictors of OS. These predictors were then incorporated into preoperative and postoperative nomograms, respectively. The C‐index of the preoperative nomogram was 0.661 (95% CI, 0.627 to 0.694) for OS prediction and correctly delineated four subgroups (5‐year OS rates: 48.1%, 19.0%, 15.6%, and 8.1%, p < 0.001). The C‐index of the postoperative nomogram was 0.778 (95%CI, 0.756 –0.800). Furthermore, this nomogram was superior to the 8th TNM system in both C‐index and the net benefit on decision curve analysis. The results were externally validated. Conclusion The two nomograms showed an optimally prognostic prediction in GBC patients after curative‐intent resection. |
| first_indexed | 2024-04-24T17:11:07Z |
| format | Article |
| id | doaj.art-e9d9b46b561849d2b49c74840f623e02 |
| institution | Directory Open Access Journal |
| issn | 2573-8348 |
| language | English |
| last_indexed | 2024-04-24T17:11:07Z |
| publishDate | 2024-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Reports |
| spelling | doaj.art-e9d9b46b561849d2b49c74840f623e022024-03-28T12:30:35ZengWileyCancer Reports2573-83482024-03-0173n/an/a10.1002/cnr2.1991Nomograms to predict long‐term survival for patients with gallbladder carcinoma after resectionShilei Bai0Pinghua Yang1Jiliang Qiu2Jie Wang3Liu Liu4Chunyan Wang5Huifeng Wang6Zhijian Wen7Baohua Zhang8Department of Hepatic Surgery II The Eastern Hepatobiliary Surgery Hospital, Naval Medical University Shanghai ChinaDepartment of Biliary Surgery IV The Eastern Hepatobiliary Surgery Hospital, Naval Medical University Shanghai ChinaDepartment of Hepatobiliary Surgery Sun Yat‐Sen University Cancer Center Guangzhou ChinaDepartment of Hepatic Surgery II The Eastern Hepatobiliary Surgery Hospital, Naval Medical University Shanghai ChinaDepartment of Hepatic Surgery II The Eastern Hepatobiliary Surgery Hospital, Naval Medical University Shanghai ChinaDepartment of Hepatic Surgery II The Eastern Hepatobiliary Surgery Hospital, Naval Medical University Shanghai ChinaDepartment of Hepatic Surgery The Fifth Clinical Medical College of Henan University of Chinese MedicineDepartment of Hepatobiliary Pancreatic Vascular Surgery The Chenggong Hospital, Xiamen University Xiamen ChinaDepartment of Biliary Surgery IV The Eastern Hepatobiliary Surgery Hospital, Naval Medical University Shanghai ChinaAbstract Background Surgical resection remains the primary treatment option for gallbladder carcinoma (GBC). However, there is a pressing demand for prognostic tools that can refine patients' treatment choices and tailor personalized therapies accordingly. Aims The nomograms were constructed using the data of a training cohort (n = 378) of GBC patients at Eastern Hepatobiliary Surgery Hospital (EHBH) between 2008 and 2018. The model's performance was validated in GBC patients (n = 108) at Guangzhou Centre from 2007 to 2018. Methods and results The 5‐year overall survival (OS) rate in the training cohort was 24.4%. Multivariate analyses were performed using preoperative and postoperative data to identify independent predictors of OS. These predictors were then incorporated into preoperative and postoperative nomograms, respectively. The C‐index of the preoperative nomogram was 0.661 (95% CI, 0.627 to 0.694) for OS prediction and correctly delineated four subgroups (5‐year OS rates: 48.1%, 19.0%, 15.6%, and 8.1%, p < 0.001). The C‐index of the postoperative nomogram was 0.778 (95%CI, 0.756 –0.800). Furthermore, this nomogram was superior to the 8th TNM system in both C‐index and the net benefit on decision curve analysis. The results were externally validated. Conclusion The two nomograms showed an optimally prognostic prediction in GBC patients after curative‐intent resection.https://doi.org/10.1002/cnr2.1991decision curve analysisgallbladder carcinomanomogramprognosisresectionTNM system |
| spellingShingle | Shilei Bai Pinghua Yang Jiliang Qiu Jie Wang Liu Liu Chunyan Wang Huifeng Wang Zhijian Wen Baohua Zhang Nomograms to predict long‐term survival for patients with gallbladder carcinoma after resection Cancer Reports decision curve analysis gallbladder carcinoma nomogram prognosis resection TNM system |
| title | Nomograms to predict long‐term survival for patients with gallbladder carcinoma after resection |
| title_full | Nomograms to predict long‐term survival for patients with gallbladder carcinoma after resection |
| title_fullStr | Nomograms to predict long‐term survival for patients with gallbladder carcinoma after resection |
| title_full_unstemmed | Nomograms to predict long‐term survival for patients with gallbladder carcinoma after resection |
| title_short | Nomograms to predict long‐term survival for patients with gallbladder carcinoma after resection |
| title_sort | nomograms to predict long term survival for patients with gallbladder carcinoma after resection |
| topic | decision curve analysis gallbladder carcinoma nomogram prognosis resection TNM system |
| url | https://doi.org/10.1002/cnr2.1991 |
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