Preventive Effect of Gamma-Oryzanol on Physiopathological Process Related to Nonalcoholic Fatty Liver Disease in Animals Submitted to High Sugar/Fat Diet
Nonalcoholic fatty liver disease (NAFLD) is the main cause of liver disease. The physiopathological processes involved in the disease are metabolic syndrome (MetS) components (central obesity, dyslipidemia, insulin resistance/type 2 diabetes, hypertension), genetic, and dietary factors, including un...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | Livers |
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| Online Access: | https://www.mdpi.com/2673-4389/2/3/13 |
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| author | Fabiane Valentini Francisqueti-Ferron Janaina Paixão das Chagas Silva Jéssica Leite Garcia Artur Junio Togneri Ferron Hugo Tadashi Kano Carol Cristina Vágula de Almeida Silva Mariane Róvero Costa Gisele Alborghetti Nai Fernando Moreto Camila Renata Corrêa |
| author_facet | Fabiane Valentini Francisqueti-Ferron Janaina Paixão das Chagas Silva Jéssica Leite Garcia Artur Junio Togneri Ferron Hugo Tadashi Kano Carol Cristina Vágula de Almeida Silva Mariane Róvero Costa Gisele Alborghetti Nai Fernando Moreto Camila Renata Corrêa |
| author_sort | Fabiane Valentini Francisqueti-Ferron |
| collection | DOAJ |
| description | Nonalcoholic fatty liver disease (NAFLD) is the main cause of liver disease. The physiopathological processes involved in the disease are metabolic syndrome (MetS) components (central obesity, dyslipidemia, insulin resistance/type 2 diabetes, hypertension), genetic, and dietary factors, including unsaturated fats and sweetened beverages, which are able to lead to inflammation and oxidative stress, conditions associated with progression and severity of NAFLD. Gamma-oryzanol (γOz) is a nutraceutical obtained from rice brain oil with many benefits to health, from immunological to metabolic. The aim of this study is to test the preventive effect of γOz on the physiopathological process related to nonalcoholic fatty liver disease in animals submitted to high sugar/fat diet. Male Wistar rats (±187 g) were randomly divided into four experimental groups to receive: control diet (C, <i>n</i> = 6), control diet plus γOz (C + γOz, <i>n</i> = 6), high sugar/fat diet (HSF, <i>n</i> = 6), or high sugar/fat diet plus γOz (HSF + γOz, <i>n</i> = 6) during 30 weeks. HSF groups also received water plus sucrose (25%). γOz was added to diets to reach 0.5% of final concentration. The HSF group presented MetS, liver inflammation and oxidative stress, and micro and macrovesicular steatosis. HSF plus γOz was protected against these changes. It is possible to conclude that gamma-oryzanol was effective in modulating the physiopathological process related to nonalcoholic fatty liver disease in animals submitted to a high sugar/fat diet. |
| first_indexed | 2024-03-09T23:22:56Z |
| format | Article |
| id | doaj.art-e9dc79bbd1f2428bb536903f862b5221 |
| institution | Directory Open Access Journal |
| issn | 2673-4389 |
| language | English |
| last_indexed | 2024-03-09T23:22:56Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Livers |
| spelling | doaj.art-e9dc79bbd1f2428bb536903f862b52212023-11-23T17:24:34ZengMDPI AGLivers2673-43892022-08-012314615710.3390/livers2030013Preventive Effect of Gamma-Oryzanol on Physiopathological Process Related to Nonalcoholic Fatty Liver Disease in Animals Submitted to High Sugar/Fat DietFabiane Valentini Francisqueti-Ferron0Janaina Paixão das Chagas Silva1Jéssica Leite Garcia2Artur Junio Togneri Ferron3Hugo Tadashi Kano4Carol Cristina Vágula de Almeida Silva5Mariane Róvero Costa6Gisele Alborghetti Nai7Fernando Moreto8Camila Renata Corrêa9Medical School, São Paulo State University (UNESP), Botucatu 18618-687, SP, BrazilInstitute of Biosciences, São Paulo State University (UNESP), Botucatu 18618-687, SP, BrazilMedical School, São Paulo State University (UNESP), Botucatu 18618-687, SP, BrazilMedical School, São Paulo State University (UNESP), Botucatu 18618-687, SP, BrazilMedical School, São Paulo State University (UNESP), Botucatu 18618-687, SP, BrazilMedical School, São Paulo State University (UNESP), Botucatu 18618-687, SP, BrazilMedical School, São Paulo State University (UNESP), Botucatu 18618-687, SP, BrazilDepartment of Pathological Anatomy and Cytopathology, Universidade do Oeste Paulista (UNOESTE), Presidente Prudente 19050-680, SP, BrazilMedical School, São Paulo State University (UNESP), Botucatu 18618-687, SP, BrazilMedical School, São Paulo State University (UNESP), Botucatu 18618-687, SP, BrazilNonalcoholic fatty liver disease (NAFLD) is the main cause of liver disease. The physiopathological processes involved in the disease are metabolic syndrome (MetS) components (central obesity, dyslipidemia, insulin resistance/type 2 diabetes, hypertension), genetic, and dietary factors, including unsaturated fats and sweetened beverages, which are able to lead to inflammation and oxidative stress, conditions associated with progression and severity of NAFLD. Gamma-oryzanol (γOz) is a nutraceutical obtained from rice brain oil with many benefits to health, from immunological to metabolic. The aim of this study is to test the preventive effect of γOz on the physiopathological process related to nonalcoholic fatty liver disease in animals submitted to high sugar/fat diet. Male Wistar rats (±187 g) were randomly divided into four experimental groups to receive: control diet (C, <i>n</i> = 6), control diet plus γOz (C + γOz, <i>n</i> = 6), high sugar/fat diet (HSF, <i>n</i> = 6), or high sugar/fat diet plus γOz (HSF + γOz, <i>n</i> = 6) during 30 weeks. HSF groups also received water plus sucrose (25%). γOz was added to diets to reach 0.5% of final concentration. The HSF group presented MetS, liver inflammation and oxidative stress, and micro and macrovesicular steatosis. HSF plus γOz was protected against these changes. It is possible to conclude that gamma-oryzanol was effective in modulating the physiopathological process related to nonalcoholic fatty liver disease in animals submitted to a high sugar/fat diet.https://www.mdpi.com/2673-4389/2/3/13nonalcoholic fatty liver diseasegamma-oryzanolmetabolic syndromebioactive compounds |
| spellingShingle | Fabiane Valentini Francisqueti-Ferron Janaina Paixão das Chagas Silva Jéssica Leite Garcia Artur Junio Togneri Ferron Hugo Tadashi Kano Carol Cristina Vágula de Almeida Silva Mariane Róvero Costa Gisele Alborghetti Nai Fernando Moreto Camila Renata Corrêa Preventive Effect of Gamma-Oryzanol on Physiopathological Process Related to Nonalcoholic Fatty Liver Disease in Animals Submitted to High Sugar/Fat Diet Livers nonalcoholic fatty liver disease gamma-oryzanol metabolic syndrome bioactive compounds |
| title | Preventive Effect of Gamma-Oryzanol on Physiopathological Process Related to Nonalcoholic Fatty Liver Disease in Animals Submitted to High Sugar/Fat Diet |
| title_full | Preventive Effect of Gamma-Oryzanol on Physiopathological Process Related to Nonalcoholic Fatty Liver Disease in Animals Submitted to High Sugar/Fat Diet |
| title_fullStr | Preventive Effect of Gamma-Oryzanol on Physiopathological Process Related to Nonalcoholic Fatty Liver Disease in Animals Submitted to High Sugar/Fat Diet |
| title_full_unstemmed | Preventive Effect of Gamma-Oryzanol on Physiopathological Process Related to Nonalcoholic Fatty Liver Disease in Animals Submitted to High Sugar/Fat Diet |
| title_short | Preventive Effect of Gamma-Oryzanol on Physiopathological Process Related to Nonalcoholic Fatty Liver Disease in Animals Submitted to High Sugar/Fat Diet |
| title_sort | preventive effect of gamma oryzanol on physiopathological process related to nonalcoholic fatty liver disease in animals submitted to high sugar fat diet |
| topic | nonalcoholic fatty liver disease gamma-oryzanol metabolic syndrome bioactive compounds |
| url | https://www.mdpi.com/2673-4389/2/3/13 |
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