Mendelian randomization analyses of smoking and Alzheimer’s disease in Chinese and Japanese populations

Mendelian randomization analyses of smoking and Alzheimer’s disease in Chinese and Japanese populations

BackgroundPrevious epidemiological studies have reported controversial results on the relationship between smoking and Alzheimer’s disease (AD). Therefore, we sought to assess the association using Mendelian randomization (MR) analysis.MethodsWe used single nucleotide polymorphisms (SNPs) associated...

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Bibliographic Details
Main Authors: Yuan Zhu, Ying Guan, Xuewen Xiao, Bin Jiao, Xinxin Liao, Hui Zhou, Xixi Liu, Feiyan Qi, Qiyuan Peng, Lu Zhou, Tianyan Xu, Qijie Yang, Sizhe Zhang, Meng Li, Zhouhai Zhu, Sheming Lu, Jinchen Li, Beisha Tang, Lu Shen, Jianhua Yao, Yafang Zhou
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Aging Neuroscience
Subjects:
Alzheimer’s disease
smoking
two-sample Mendelian randomization analysis
causal association
East Asian population
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2023.1157051/full
Description
Summary:BackgroundPrevious epidemiological studies have reported controversial results on the relationship between smoking and Alzheimer’s disease (AD). Therefore, we sought to assess the association using Mendelian randomization (MR) analysis.MethodsWe used single nucleotide polymorphisms (SNPs) associated with smoking quantity (cigarettes per day, CPD) from genome-wide association studies (GWAS) of Japanese population as instrumental variables, then we performed two-sample MR analysis to investigate the association between smoking and AD in a Chinese cohort (1,000 AD cases and 500 controls) and a Japanese cohort (3,962 AD cases and 4,074 controls), respectively.ResultsGenetically higher smoking quantity showed no statistical causal association with AD risk (the inverse variance weighted (IVW) estimate in the Chinese cohort: odds ratio (OR) = 0.510, 95% confidence interval (CI) = 0.149–1.744, p = 0.284; IVW estimate in the Japanese cohort: OR = 1.170, 95% confidence interval CI = 0.790–1.734, p = 0.434).ConclusionThis MR study, for the first time in Chinese and Japanese populations, found no significant association between smoking and AD.
ISSN:1663-4365

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