Antidiabetic Activity of Elephant Grass (Cenchrus Purpureus (Schumach.) Morrone) via Activation of PI3K/AkT Signaling Pathway, Oxidative Stress Inhibition, and Apoptosis in Wistar Rats

Antidiabetic Activity of Elephant Grass (Cenchrus Purpureus (Schumach.) Morrone) via Activation of PI3K/AkT Signaling Pathway, Oxidative Stress Inhibition, and Apoptosis in Wistar Rats

Ethnopharmacological Relevance: The management of diabetes over the years has involved the use of herbal plants, which are now attracting interest. We assessed the antidiabetic properties of aqueous extract of C. purpureus shoots (AECPS) and the mechanism of action on pancreatic ß-cell dysfunction.M...

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Main Authors: Oluwafemi Adeleke Ojo, Abosede Itunuoluwa Oni, Susan Grant, Jennifer Amanze, Adebola Busola Ojo, Odunayo Anthonia Taiwo, Rotdelmwa Filibus Maimako, Ikponmwosa Owen Evbuomwan, Matthew Iyobhebhe, Charles Obiora Nwonuma, Omorefosa Osemwegie, Anthonia Oluyemi Agboola, Christopher Akintayo, Nnaemeka Tobechukwu Asogwa, Nada H. Aljarba, Saad Alkahtani, Gomaa Mostafa-Hedeab, Gaber El-Saber Batiha, Oluyomi Stephen Adeyemi
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Pharmacology
Subjects:
diabetes
inflammation
apoptosis
PI3K/akt signalling pathway
aqueous extract of Cenchrus purpureus
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.845196/full

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