Early Postpartum Venous Thromboembolism: Risk Factors and Predictive Index
The aim of our study was to quantify risk factors for venous thromboembolism (VTE) during the puerperal period. The case–control study was conducted in Women’s Hospital, Zhejiang University, China, from January 2006 to December 2016; cases of hospitalized VTE within 1 week after delivery were identi...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2019-03-01
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| Series: | Clinical and Applied Thrombosis/Hemostasis |
| Online Access: | https://doi.org/10.1177/1076029618818777 |
| _version_ | 1818068359615348736 |
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| author | Zhi-Hua Zhou MD Yuan Chen MD Bai-Hui Zhao MD Ying Jiang MD Qiong Luo MD |
| author_facet | Zhi-Hua Zhou MD Yuan Chen MD Bai-Hui Zhao MD Ying Jiang MD Qiong Luo MD |
| author_sort | Zhi-Hua Zhou MD |
| collection | DOAJ |
| description | The aim of our study was to quantify risk factors for venous thromboembolism (VTE) during the puerperal period. The case–control study was conducted in Women’s Hospital, Zhejiang University, China, from January 2006 to December 2016; cases of hospitalized VTE within 1 week after delivery were identified according to International Classification of Diseases, Ninth Revision, Clinical Modification codes . Control postpartum women without VTE were randomly selected, matched on birth day, age, delivery mode, and number of fetus with 4:1 ratio. Clinical risk factors for postpartum VTE and coagulation parameters were analyzed. We found independent variables that were significantly related to postpartum VTE (all P < .05) in a binary logistic regression analysis included preeclampsia/eclampsia (odds ratio [OR], 2.89; 95% confidence interval [CI], 1.56-5.37) and postpartum hemorrhage (OR, 4.6; 95% CI, 1.71-12.40). D-dimer was the only biomarker that statistically significant associated with postpartum VTE in 3 days after delivery (all P < .05). These findings showed preeclampsia/eclampsia and postpartum hemorrhage were important risk factors for early VTE during puerperal period. A higher level of D-dimer was more meaningful than other coagulation parameters to suspect early thrombotic disease after delivery. |
| first_indexed | 2024-12-10T15:38:20Z |
| format | Article |
| id | doaj.art-e9e2cd8974ff453693394d89862a6952 |
| institution | Directory Open Access Journal |
| issn | 1938-2723 |
| language | English |
| last_indexed | 2024-12-10T15:38:20Z |
| publishDate | 2019-03-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Clinical and Applied Thrombosis/Hemostasis |
| spelling | doaj.art-e9e2cd8974ff453693394d89862a69522022-12-22T01:43:11ZengSAGE PublishingClinical and Applied Thrombosis/Hemostasis1938-27232019-03-012510.1177/1076029618818777Early Postpartum Venous Thromboembolism: Risk Factors and Predictive IndexZhi-Hua Zhou MD0Yuan Chen MD1Bai-Hui Zhao MD2Ying Jiang MD3Qiong Luo MD4 Department of Obstetrics, Women’s Hospital, School of Medicine, Zhejiang University, Hangzhou, China Department of Obstetrics, Women’s Hospital, School of Medicine, Zhejiang University, Hangzhou, China Department of Obstetrics, Women’s Hospital, School of Medicine, Zhejiang University, Hangzhou, China Department of Obstetrics, Women’s Hospital, School of Medicine, Zhejiang University, Hangzhou, China Department of Obstetrics, Women’s Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaThe aim of our study was to quantify risk factors for venous thromboembolism (VTE) during the puerperal period. The case–control study was conducted in Women’s Hospital, Zhejiang University, China, from January 2006 to December 2016; cases of hospitalized VTE within 1 week after delivery were identified according to International Classification of Diseases, Ninth Revision, Clinical Modification codes . Control postpartum women without VTE were randomly selected, matched on birth day, age, delivery mode, and number of fetus with 4:1 ratio. Clinical risk factors for postpartum VTE and coagulation parameters were analyzed. We found independent variables that were significantly related to postpartum VTE (all P < .05) in a binary logistic regression analysis included preeclampsia/eclampsia (odds ratio [OR], 2.89; 95% confidence interval [CI], 1.56-5.37) and postpartum hemorrhage (OR, 4.6; 95% CI, 1.71-12.40). D-dimer was the only biomarker that statistically significant associated with postpartum VTE in 3 days after delivery (all P < .05). These findings showed preeclampsia/eclampsia and postpartum hemorrhage were important risk factors for early VTE during puerperal period. A higher level of D-dimer was more meaningful than other coagulation parameters to suspect early thrombotic disease after delivery.https://doi.org/10.1177/1076029618818777 |
| spellingShingle | Zhi-Hua Zhou MD Yuan Chen MD Bai-Hui Zhao MD Ying Jiang MD Qiong Luo MD Early Postpartum Venous Thromboembolism: Risk Factors and Predictive Index Clinical and Applied Thrombosis/Hemostasis |
| title | Early Postpartum Venous Thromboembolism: Risk Factors and Predictive Index |
| title_full | Early Postpartum Venous Thromboembolism: Risk Factors and Predictive Index |
| title_fullStr | Early Postpartum Venous Thromboembolism: Risk Factors and Predictive Index |
| title_full_unstemmed | Early Postpartum Venous Thromboembolism: Risk Factors and Predictive Index |
| title_short | Early Postpartum Venous Thromboembolism: Risk Factors and Predictive Index |
| title_sort | early postpartum venous thromboembolism risk factors and predictive index |
| url | https://doi.org/10.1177/1076029618818777 |
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