Adverse effects of irreversible electroporation of malignant liver tumors under CT fluoroscopic guidance: a single-center experience
PURPOSEWe aimed to describe the frequency of adverse events after computed tomography (CT) fluoroscopy-guided irreversible electroporation (IRE) of malignant hepatic tumors and their risk factors.METHODSWe retrospectively analyzed 85 IRE ablation procedures of 114 malignant liver tumors (52 primary...
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| Format: | Article |
| Language: | English |
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Galenos Publishing House
2015-11-01
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| Series: | Diagnostic and Interventional Radiology |
| Online Access: |
http://www.dirjournal.org/archives/archive-detail/article-preview/adverse-effects-of-irreversible-electroporation-of/55613
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| _version_ | 1827823336496824320 |
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| author | Marco Dollinger Lukas Philipp Beyer Michael Haimerl Christoph Niessen Ernst-Michael Jung Florian Zeman Christian Stroszczynski Philipp Wiggermann |
| author_facet | Marco Dollinger Lukas Philipp Beyer Michael Haimerl Christoph Niessen Ernst-Michael Jung Florian Zeman Christian Stroszczynski Philipp Wiggermann |
| author_sort | Marco Dollinger |
| collection | DOAJ |
| description | PURPOSEWe aimed to describe the frequency of adverse events after computed tomography (CT) fluoroscopy-guided irreversible electroporation (IRE) of malignant hepatic tumors and their risk factors.METHODSWe retrospectively analyzed 85 IRE ablation procedures of 114 malignant liver tumors (52 primary and 62 secondary) not suitable for resection or thermal ablation in 56 patients (42 men and 14 women; median age, 61 years) with regard to mortality and treatment-related complications. Complications were evaluated according to the standardized grading system of the Society of Interventional Radiology. Factors influencing the occurrence of major and minor complications were investigated.RESULTSNo IRE-related death occurred. Major complications occurred in 7.1% of IRE procedures (6/85), while minor complications occurred in 18.8% (16/85). The most frequent major complication was postablative abscess (4.7%, 4/85) which affected patients with bilioenteric anastomosis significantly more often than patients without this condition (43% vs. 1.3%, P = 0.010). Bilioenteric anastomosis was additionally identified as a risk factor for major complications in general (P = 0.002). Minor complications mainly consisted of hemorrhage and portal vein branch thrombosis.CONCLUSIONThe current study suggests that CT fluoroscopy-guided IRE ablation of malignant liver tumors may be a relatively low-risk procedure. However, patients with bilioenteric anastomosis seem to have an increased risk of postablative abscess formation. |
| first_indexed | 2024-03-12T02:10:39Z |
| format | Article |
| id | doaj.art-e9e39cb052c44cdc99f22a5710310995 |
| institution | Directory Open Access Journal |
| issn | 1305-3825 1305-3612 |
| language | English |
| last_indexed | 2024-03-12T02:10:39Z |
| publishDate | 2015-11-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Diagnostic and Interventional Radiology |
| spelling | doaj.art-e9e39cb052c44cdc99f22a57103109952023-09-06T13:45:16ZengGalenos Publishing HouseDiagnostic and Interventional Radiology1305-38251305-36122015-11-0121647147510.5152/dir.2015.1444213049054Adverse effects of irreversible electroporation of malignant liver tumors under CT fluoroscopic guidance: a single-center experienceMarco Dollinger0Lukas Philipp Beyer1Michael Haimerl2Christoph Niessen3Ernst-Michael Jung4Florian Zeman5Christian Stroszczynski6Philipp Wiggermann7 Department of Radiology, University Medical Center Regensburg, Regensburg, Germany Department of Radiology, University Medical Center Regensburg, Regensburg, Germany Department of Radiology, University Medical Center Regensburg, Regensburg, Germany Department of Radiology, University Medical Center Regensburg, Regensburg, Germany Department of Radiology, University Medical Center Regensburg, Regensburg, Germany Department of Center for Clinical Studies, University Medical Center Regensburg, Regensburg, Germany Department of Radiology, University Medical Center Regensburg, Regensburg, Germany Department of Radiology, University Medical Center Regensburg, Regensburg, Germany PURPOSEWe aimed to describe the frequency of adverse events after computed tomography (CT) fluoroscopy-guided irreversible electroporation (IRE) of malignant hepatic tumors and their risk factors.METHODSWe retrospectively analyzed 85 IRE ablation procedures of 114 malignant liver tumors (52 primary and 62 secondary) not suitable for resection or thermal ablation in 56 patients (42 men and 14 women; median age, 61 years) with regard to mortality and treatment-related complications. Complications were evaluated according to the standardized grading system of the Society of Interventional Radiology. Factors influencing the occurrence of major and minor complications were investigated.RESULTSNo IRE-related death occurred. Major complications occurred in 7.1% of IRE procedures (6/85), while minor complications occurred in 18.8% (16/85). The most frequent major complication was postablative abscess (4.7%, 4/85) which affected patients with bilioenteric anastomosis significantly more often than patients without this condition (43% vs. 1.3%, P = 0.010). Bilioenteric anastomosis was additionally identified as a risk factor for major complications in general (P = 0.002). Minor complications mainly consisted of hemorrhage and portal vein branch thrombosis.CONCLUSIONThe current study suggests that CT fluoroscopy-guided IRE ablation of malignant liver tumors may be a relatively low-risk procedure. However, patients with bilioenteric anastomosis seem to have an increased risk of postablative abscess formation. http://www.dirjournal.org/archives/archive-detail/article-preview/adverse-effects-of-irreversible-electroporation-of/55613 |
| spellingShingle | Marco Dollinger Lukas Philipp Beyer Michael Haimerl Christoph Niessen Ernst-Michael Jung Florian Zeman Christian Stroszczynski Philipp Wiggermann Adverse effects of irreversible electroporation of malignant liver tumors under CT fluoroscopic guidance: a single-center experience Diagnostic and Interventional Radiology |
| title | Adverse effects of irreversible electroporation of malignant liver tumors under CT fluoroscopic guidance: a single-center experience |
| title_full | Adverse effects of irreversible electroporation of malignant liver tumors under CT fluoroscopic guidance: a single-center experience |
| title_fullStr | Adverse effects of irreversible electroporation of malignant liver tumors under CT fluoroscopic guidance: a single-center experience |
| title_full_unstemmed | Adverse effects of irreversible electroporation of malignant liver tumors under CT fluoroscopic guidance: a single-center experience |
| title_short | Adverse effects of irreversible electroporation of malignant liver tumors under CT fluoroscopic guidance: a single-center experience |
| title_sort | adverse effects of irreversible electroporation of malignant liver tumors under ct fluoroscopic guidance a single center experience |
| url |
http://www.dirjournal.org/archives/archive-detail/article-preview/adverse-effects-of-irreversible-electroporation-of/55613
|
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