Primary Synovial Sarcoma of the Scrotum
The report outlines a case of synovial sarcoma in the scrotal region. A 36-year-old male presented with a scrotal swelling. The lesion was completely resected, whereas the histopathologic examination revealed a spindle cell tumor. The tumor stained positive for pancytokeratin, AE1/AE3, epithelial me...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Hindawi Limited
2023-01-01
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| Series: | Case Reports in Pathology |
| Online Access: | http://dx.doi.org/10.1155/2023/7839846 |
| _version_ | 1797364400891363328 |
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| author | Nourah Al-Oudah Sara Alanazi Sarah Saad Alotaibi Nayef Alzahrani |
| author_facet | Nourah Al-Oudah Sara Alanazi Sarah Saad Alotaibi Nayef Alzahrani |
| author_sort | Nourah Al-Oudah |
| collection | DOAJ |
| description | The report outlines a case of synovial sarcoma in the scrotal region. A 36-year-old male presented with a scrotal swelling. The lesion was completely resected, whereas the histopathologic examination revealed a spindle cell tumor. The tumor stained positive for pancytokeratin, AE1/AE3, epithelial membrane antigen (EMA), TLE-1, CD99, and BCL-2. The cytogenetic testing showed a chromosomal translocation in the SS18 gene at 18q11.2, consistent with the diagnosis of primary synovial sarcoma. A year later, the patient developed liver, vertebrae, and lung metastasis, which was treated with systemic chemotherapy. Treatment failed to improve the hepatic lesion that was then resected, while the spine and lung lesions were followed by radiotherapy. The patient is now alive and subject to an outstanding follow-up. |
| first_indexed | 2024-03-08T16:34:48Z |
| format | Article |
| id | doaj.art-e9e3a04ba98049d785ad0fb2c5ac0549 |
| institution | Directory Open Access Journal |
| issn | 2090-679X |
| language | English |
| last_indexed | 2024-03-08T16:34:48Z |
| publishDate | 2023-01-01 |
| publisher | Hindawi Limited |
| record_format | Article |
| series | Case Reports in Pathology |
| spelling | doaj.art-e9e3a04ba98049d785ad0fb2c5ac05492024-01-06T00:00:06ZengHindawi LimitedCase Reports in Pathology2090-679X2023-01-01202310.1155/2023/7839846Primary Synovial Sarcoma of the ScrotumNourah Al-Oudah0Sara Alanazi1Sarah Saad Alotaibi2Nayef Alzahrani3Department of Pathology and Laboratory MedicineDepartment of SurgeryDepartment of Pathology and Laboratory MedicineDepartment of Pathology and Laboratory MedicineThe report outlines a case of synovial sarcoma in the scrotal region. A 36-year-old male presented with a scrotal swelling. The lesion was completely resected, whereas the histopathologic examination revealed a spindle cell tumor. The tumor stained positive for pancytokeratin, AE1/AE3, epithelial membrane antigen (EMA), TLE-1, CD99, and BCL-2. The cytogenetic testing showed a chromosomal translocation in the SS18 gene at 18q11.2, consistent with the diagnosis of primary synovial sarcoma. A year later, the patient developed liver, vertebrae, and lung metastasis, which was treated with systemic chemotherapy. Treatment failed to improve the hepatic lesion that was then resected, while the spine and lung lesions were followed by radiotherapy. The patient is now alive and subject to an outstanding follow-up.http://dx.doi.org/10.1155/2023/7839846 |
| spellingShingle | Nourah Al-Oudah Sara Alanazi Sarah Saad Alotaibi Nayef Alzahrani Primary Synovial Sarcoma of the Scrotum Case Reports in Pathology |
| title | Primary Synovial Sarcoma of the Scrotum |
| title_full | Primary Synovial Sarcoma of the Scrotum |
| title_fullStr | Primary Synovial Sarcoma of the Scrotum |
| title_full_unstemmed | Primary Synovial Sarcoma of the Scrotum |
| title_short | Primary Synovial Sarcoma of the Scrotum |
| title_sort | primary synovial sarcoma of the scrotum |
| url | http://dx.doi.org/10.1155/2023/7839846 |
| work_keys_str_mv | AT nourahaloudah primarysynovialsarcomaofthescrotum AT saraalanazi primarysynovialsarcomaofthescrotum AT sarahsaadalotaibi primarysynovialsarcomaofthescrotum AT nayefalzahrani primarysynovialsarcomaofthescrotum |