Convenient and Robust Metal-Free Synthesis of Benzazole-2-Ones Through the Reaction of Aniline Derivatives and Sodium Cyanate in Aqueous Medium
Benzazole-2-ones (benzimidazolones, benzothiazolones, benzoxazolones) are important derivatives of benzazole compounds that exist widely in many biologically and pharmaceutically active molecules. Furthermore, benzazole-2-one derivatives also have many applications in agrochemical and material scien...
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| Format: | Article |
| Language: | English |
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Iranian Institute of Research and Development in Chemical Industries (IRDCI)-ACECR
2020-10-01
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| Series: | Iranian Journal of Chemistry & Chemical Engineering |
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| Online Access: | http://www.ijcce.ac.ir/article_36288_52716342806f57045441185ecf1aa7c2.pdf |
| _version_ | 1818891198788534272 |
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| author | Esmail Vessally Somayeh Mohammadi Morteza Abdoli Akram Hosseinian Parisa Ojaghloo |
| author_facet | Esmail Vessally Somayeh Mohammadi Morteza Abdoli Akram Hosseinian Parisa Ojaghloo |
| author_sort | Esmail Vessally |
| collection | DOAJ |
| description | Benzazole-2-ones (benzimidazolones, benzothiazolones, benzoxazolones) are important derivatives of benzazole compounds that exist widely in many biologically and pharmaceutically active molecules. Furthermore, benzazole-2-one derivatives also have many applications in agrochemical and material science. Herein, a novel, practical and green synthesis of titled compounds by the reaction of aniline derivatives with inexpensive and easily accessible sodium cyanate has been reported. Good to excellent yields of products have been obtained under catalyst- and ligand-free conditions in water as solvent. This procedure avoids the use of time-consuming and tedious column chromatography and the products were easily isolated by simple extraction followed by washing with dichloromethane. |
| first_indexed | 2024-12-19T17:37:00Z |
| format | Article |
| id | doaj.art-e9e443e428c9489aa8cdd72dc8992092 |
| institution | Directory Open Access Journal |
| issn | 1021-9986 1021-9986 |
| language | English |
| last_indexed | 2024-12-19T17:37:00Z |
| publishDate | 2020-10-01 |
| publisher | Iranian Institute of Research and Development in Chemical Industries (IRDCI)-ACECR |
| record_format | Article |
| series | Iranian Journal of Chemistry & Chemical Engineering |
| spelling | doaj.art-e9e443e428c9489aa8cdd72dc89920922022-12-21T20:12:18ZengIranian Institute of Research and Development in Chemical Industries (IRDCI)-ACECRIranian Journal of Chemistry & Chemical Engineering1021-99861021-99862020-10-01395111910.30492/ijcce.2019.3628836288Convenient and Robust Metal-Free Synthesis of Benzazole-2-Ones Through the Reaction of Aniline Derivatives and Sodium Cyanate in Aqueous MediumEsmail Vessally0Somayeh Mohammadi1Morteza Abdoli2Akram Hosseinian3Parisa Ojaghloo4Department of Chemistry, Payame Noor University, Tehran, I.R. IRANDepartment of Chemistry, Payame Noor University, Tehran, I.R. IRANDepartment of Chemistry, Payame Noor University, Tehran, I.R. IRANSchool of Engineering Science, College of Engineering, University of Tehran, Tehran, I.R. IRANDepartment of Chemistry, Payame Noor University, Tehran, I.R. IRANBenzazole-2-ones (benzimidazolones, benzothiazolones, benzoxazolones) are important derivatives of benzazole compounds that exist widely in many biologically and pharmaceutically active molecules. Furthermore, benzazole-2-one derivatives also have many applications in agrochemical and material science. Herein, a novel, practical and green synthesis of titled compounds by the reaction of aniline derivatives with inexpensive and easily accessible sodium cyanate has been reported. Good to excellent yields of products have been obtained under catalyst- and ligand-free conditions in water as solvent. This procedure avoids the use of time-consuming and tedious column chromatography and the products were easily isolated by simple extraction followed by washing with dichloromethane.http://www.ijcce.ac.ir/article_36288_52716342806f57045441185ecf1aa7c2.pdfbenzazole-2-onesbenzimidazolones, benzothiazolonesbenzoxazolonessodium cyanategreen chemistrywatersynthesis |
| spellingShingle | Esmail Vessally Somayeh Mohammadi Morteza Abdoli Akram Hosseinian Parisa Ojaghloo Convenient and Robust Metal-Free Synthesis of Benzazole-2-Ones Through the Reaction of Aniline Derivatives and Sodium Cyanate in Aqueous Medium Iranian Journal of Chemistry & Chemical Engineering benzazole-2-ones benzimidazolones, benzothiazolones benzoxazolones sodium cyanate green chemistry water synthesis |
| title | Convenient and Robust Metal-Free Synthesis of Benzazole-2-Ones Through the Reaction of Aniline Derivatives and Sodium Cyanate in Aqueous Medium |
| title_full | Convenient and Robust Metal-Free Synthesis of Benzazole-2-Ones Through the Reaction of Aniline Derivatives and Sodium Cyanate in Aqueous Medium |
| title_fullStr | Convenient and Robust Metal-Free Synthesis of Benzazole-2-Ones Through the Reaction of Aniline Derivatives and Sodium Cyanate in Aqueous Medium |
| title_full_unstemmed | Convenient and Robust Metal-Free Synthesis of Benzazole-2-Ones Through the Reaction of Aniline Derivatives and Sodium Cyanate in Aqueous Medium |
| title_short | Convenient and Robust Metal-Free Synthesis of Benzazole-2-Ones Through the Reaction of Aniline Derivatives and Sodium Cyanate in Aqueous Medium |
| title_sort | convenient and robust metal free synthesis of benzazole 2 ones through the reaction of aniline derivatives and sodium cyanate in aqueous medium |
| topic | benzazole-2-ones benzimidazolones, benzothiazolones benzoxazolones sodium cyanate green chemistry water synthesis |
| url | http://www.ijcce.ac.ir/article_36288_52716342806f57045441185ecf1aa7c2.pdf |
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