Loss of PTEN Facilitates Rosiglitazone-Mediated Enhancement of Platinum(IV) Complex LA-12-Induced Apoptosis in Colon Cancer Cells.
We demonstrated for the first time an outstanding ability of rosiglitazone to mediate a profound enhancement of LA-12-induced apoptosis associated with activation of mitochondrial pathway in human colon cancer cells. This effect was preferentially observed in the G1 cell cycle phase, independent on...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2015-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4619604?pdf=render |
| _version_ | 1811230995644416000 |
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| author | Jarmila Lauková Alois Kozubík Jiřina Hofmanová Jana Nekvindová Petr Sova Mary Pat Moyer Jiří Ehrmann Alena Hyršlová Vaculová |
| author_facet | Jarmila Lauková Alois Kozubík Jiřina Hofmanová Jana Nekvindová Petr Sova Mary Pat Moyer Jiří Ehrmann Alena Hyršlová Vaculová |
| author_sort | Jarmila Lauková |
| collection | DOAJ |
| description | We demonstrated for the first time an outstanding ability of rosiglitazone to mediate a profound enhancement of LA-12-induced apoptosis associated with activation of mitochondrial pathway in human colon cancer cells. This effect was preferentially observed in the G1 cell cycle phase, independent on p53 and PPARγ proteins, and accompanied with significant changes of selected Bcl-2 family protein levels. Further stimulation of cooperative synergic cytotoxic action of rosiglitazone and LA-12 was demonstrated in the cells deficient for PTEN, where mitochondrial apoptotic pathway was more stimulated and G1-phase-associated dying was reinforced. Our results suggest that combined treatment with rosiglitazone and LA-12 might be promising anticancer strategy in colon-derived tumours regardless of their p53 status, and also favourable in those defective in PTEN function. |
| first_indexed | 2024-04-12T10:38:41Z |
| format | Article |
| id | doaj.art-e9e52676bb104a499fa76dc88f32d583 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-12T10:38:41Z |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-e9e52676bb104a499fa76dc88f32d5832022-12-22T03:36:40ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-011010e014102010.1371/journal.pone.0141020Loss of PTEN Facilitates Rosiglitazone-Mediated Enhancement of Platinum(IV) Complex LA-12-Induced Apoptosis in Colon Cancer Cells.Jarmila LaukováAlois KozubíkJiřina HofmanováJana NekvindováPetr SovaMary Pat MoyerJiří EhrmannAlena Hyršlová VaculováWe demonstrated for the first time an outstanding ability of rosiglitazone to mediate a profound enhancement of LA-12-induced apoptosis associated with activation of mitochondrial pathway in human colon cancer cells. This effect was preferentially observed in the G1 cell cycle phase, independent on p53 and PPARγ proteins, and accompanied with significant changes of selected Bcl-2 family protein levels. Further stimulation of cooperative synergic cytotoxic action of rosiglitazone and LA-12 was demonstrated in the cells deficient for PTEN, where mitochondrial apoptotic pathway was more stimulated and G1-phase-associated dying was reinforced. Our results suggest that combined treatment with rosiglitazone and LA-12 might be promising anticancer strategy in colon-derived tumours regardless of their p53 status, and also favourable in those defective in PTEN function.http://europepmc.org/articles/PMC4619604?pdf=render |
| spellingShingle | Jarmila Lauková Alois Kozubík Jiřina Hofmanová Jana Nekvindová Petr Sova Mary Pat Moyer Jiří Ehrmann Alena Hyršlová Vaculová Loss of PTEN Facilitates Rosiglitazone-Mediated Enhancement of Platinum(IV) Complex LA-12-Induced Apoptosis in Colon Cancer Cells. PLoS ONE |
| title | Loss of PTEN Facilitates Rosiglitazone-Mediated Enhancement of Platinum(IV) Complex LA-12-Induced Apoptosis in Colon Cancer Cells. |
| title_full | Loss of PTEN Facilitates Rosiglitazone-Mediated Enhancement of Platinum(IV) Complex LA-12-Induced Apoptosis in Colon Cancer Cells. |
| title_fullStr | Loss of PTEN Facilitates Rosiglitazone-Mediated Enhancement of Platinum(IV) Complex LA-12-Induced Apoptosis in Colon Cancer Cells. |
| title_full_unstemmed | Loss of PTEN Facilitates Rosiglitazone-Mediated Enhancement of Platinum(IV) Complex LA-12-Induced Apoptosis in Colon Cancer Cells. |
| title_short | Loss of PTEN Facilitates Rosiglitazone-Mediated Enhancement of Platinum(IV) Complex LA-12-Induced Apoptosis in Colon Cancer Cells. |
| title_sort | loss of pten facilitates rosiglitazone mediated enhancement of platinum iv complex la 12 induced apoptosis in colon cancer cells |
| url | http://europepmc.org/articles/PMC4619604?pdf=render |
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