Unveiling the Metal-Dependent Aggregation Properties of the C-terminal Region of Amyloidogenic Intrinsically Disordered Protein Isoforms DPF3b and DPF3a

Unveiling the Metal-Dependent Aggregation Properties of the C-terminal Region of Amyloidogenic Intrinsically Disordered Protein Isoforms DPF3b and DPF3a

Double-PHD fingers 3 (DPF3) is a BAF-associated human epigenetic regulator, which is increasingly recognised as a major contributor to various pathological contexts, such as cardiac defects, cancer, and neurodegenerative diseases. Recently, we unveiled that its two isoforms (DPF3b and DPF3a) are amy...

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Bibliographic Details
Main Authors: Tanguy Leyder, Julien Mignon, Denis Mottet, Catherine Michaux
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:International Journal of Molecular Sciences
Subjects:
double-PHD fingers 3 (DPF3)
intrinsically disordered protein
neurodegenerative diseases
aggregation
amyloid fibrillation
metal cations
Online Access:https://www.mdpi.com/1422-0067/23/23/15291

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