Mesenchymal Stem Cells in Regenerative Medicine, Possible Applications in The Restoration of Spermatogenesis: A Review
Infertility is a common clinical condition and about half of the major causes are due to male-related infertility. Pathogenesisof this abnormality is generally undefined; so establishing a proper treatment option is relatively uncertain. In recentyears, several evidences demonstrated that mesenchyma...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Royan Institute (ACECR), Tehran
2024-03-01
|
| Series: | Cell Journal |
| Subjects: | |
| Online Access: | https://www.celljournal.org/article_711803_f94236b9451094d7b541ee470e19c021.pdf |
| _version_ | 1797205810227445760 |
|---|---|
| author | Dariush Irani Davood Mehrabani Feridoun Karimi-Busheri |
| author_facet | Dariush Irani Davood Mehrabani Feridoun Karimi-Busheri |
| author_sort | Dariush Irani |
| collection | DOAJ |
| description | Infertility is a common clinical condition and about half of the major causes are due to male-related infertility. Pathogenesisof this abnormality is generally undefined; so establishing a proper treatment option is relatively uncertain. In recentyears, several evidences demonstrated that mesenchymal stem cells (MSCs) can be a hope for innovative and efficienttreatment of male infertility. This study reviews possible applications of MSCs in the restoration of spermatogenesisin male infertility of both humans and animals to suggest new avenues for future clinical practices. Articles publishedin “PubMed” and “Google Scholar” from January 1, 2000, to August 1, 2023, were investigated by searching items of“mesenchymal stem cells”, “cell therapy”, “cell transplantation”, and, “regenerative medicine” keywords, in additionto the “urology”, “andrology”, “reproductive medicine”, “male infertility”, “azoospermia”, and “spermatogenesis”. Theresults obtained from the transplantation of MSCs in the treatment of male infertility seemed encouraging and theyrevealed the safety and efficacy of these cells to recover spermatogenesis; eventhough further stem cell researchis still required before recruiting clinical application of MSCs in the treatment of human male infertility. Undertaking morewell-defined, standardized, and reproducible protocols and enrolling larger sample sizes during a longer follow-upperiod can benefit the relevance of MSC transplantation in the restoration of spermatogenesis and treatment of maleinfertility. It seems that developing and utilizing stem cell transplantations, exosomes, scaffold delivery systems, andthree dimensional (3D) culture methods may open a new window to getting more benefits from cell therapy in thetreatment of men infertility. |
| first_indexed | 2024-04-24T08:57:02Z |
| format | Article |
| id | doaj.art-e9e8211416624ac592fa89765cf712b3 |
| institution | Directory Open Access Journal |
| issn | 2228-5806 2228-5814 |
| language | English |
| last_indexed | 2024-04-24T08:57:02Z |
| publishDate | 2024-03-01 |
| publisher | Royan Institute (ACECR), Tehran |
| record_format | Article |
| series | Cell Journal |
| spelling | doaj.art-e9e8211416624ac592fa89765cf712b32024-04-16T07:17:42ZengRoyan Institute (ACECR), TehranCell Journal2228-58062228-58142024-03-0126316918410.22074/cellj.2024.2015141.1442711803Mesenchymal Stem Cells in Regenerative Medicine, Possible Applications in The Restoration of Spermatogenesis: A ReviewDariush Irani0Davood Mehrabani1Feridoun Karimi-Busheri2Department of Urology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, IranStem Cell Technology Research Center, Burn and Wound Healing Research Center, Comparative and Experimental Medicine Center, Shiraz University of Medical Sciences, Shiraz, IranDepartment of Oncology, Cross Cancer Institute, University of Alberta, Edmonton, CanadaInfertility is a common clinical condition and about half of the major causes are due to male-related infertility. Pathogenesisof this abnormality is generally undefined; so establishing a proper treatment option is relatively uncertain. In recentyears, several evidences demonstrated that mesenchymal stem cells (MSCs) can be a hope for innovative and efficienttreatment of male infertility. This study reviews possible applications of MSCs in the restoration of spermatogenesisin male infertility of both humans and animals to suggest new avenues for future clinical practices. Articles publishedin “PubMed” and “Google Scholar” from January 1, 2000, to August 1, 2023, were investigated by searching items of“mesenchymal stem cells”, “cell therapy”, “cell transplantation”, and, “regenerative medicine” keywords, in additionto the “urology”, “andrology”, “reproductive medicine”, “male infertility”, “azoospermia”, and “spermatogenesis”. Theresults obtained from the transplantation of MSCs in the treatment of male infertility seemed encouraging and theyrevealed the safety and efficacy of these cells to recover spermatogenesis; eventhough further stem cell researchis still required before recruiting clinical application of MSCs in the treatment of human male infertility. Undertaking morewell-defined, standardized, and reproducible protocols and enrolling larger sample sizes during a longer follow-upperiod can benefit the relevance of MSC transplantation in the restoration of spermatogenesis and treatment of maleinfertility. It seems that developing and utilizing stem cell transplantations, exosomes, scaffold delivery systems, andthree dimensional (3D) culture methods may open a new window to getting more benefits from cell therapy in thetreatment of men infertility.https://www.celljournal.org/article_711803_f94236b9451094d7b541ee470e19c021.pdfazoospermiamale infertilitymesenchymal stem cell transplantationreproductive medicinespermatogenesis |
| spellingShingle | Dariush Irani Davood Mehrabani Feridoun Karimi-Busheri Mesenchymal Stem Cells in Regenerative Medicine, Possible Applications in The Restoration of Spermatogenesis: A Review Cell Journal azoospermia male infertility mesenchymal stem cell transplantation reproductive medicine spermatogenesis |
| title | Mesenchymal Stem Cells in Regenerative Medicine, Possible Applications in The Restoration of Spermatogenesis: A Review |
| title_full | Mesenchymal Stem Cells in Regenerative Medicine, Possible Applications in The Restoration of Spermatogenesis: A Review |
| title_fullStr | Mesenchymal Stem Cells in Regenerative Medicine, Possible Applications in The Restoration of Spermatogenesis: A Review |
| title_full_unstemmed | Mesenchymal Stem Cells in Regenerative Medicine, Possible Applications in The Restoration of Spermatogenesis: A Review |
| title_short | Mesenchymal Stem Cells in Regenerative Medicine, Possible Applications in The Restoration of Spermatogenesis: A Review |
| title_sort | mesenchymal stem cells in regenerative medicine possible applications in the restoration of spermatogenesis a review |
| topic | azoospermia male infertility mesenchymal stem cell transplantation reproductive medicine spermatogenesis |
| url | https://www.celljournal.org/article_711803_f94236b9451094d7b541ee470e19c021.pdf |
| work_keys_str_mv | AT dariushirani mesenchymalstemcellsinregenerativemedicinepossibleapplicationsintherestorationofspermatogenesisareview AT davoodmehrabani mesenchymalstemcellsinregenerativemedicinepossibleapplicationsintherestorationofspermatogenesisareview AT feridounkarimibusheri mesenchymalstemcellsinregenerativemedicinepossibleapplicationsintherestorationofspermatogenesisareview |