The role of IL-15 deficiency in the pathogenesis of virus-induced asthma exacerbations.
Rhinovirus infections are the major cause of asthma exacerbations. We hypothesised that IL-15, a cytokine implicated in innate and acquired antiviral immunity, may be deficient in asthma and important in the pathogenesis of asthma exacerbations. We investigated regulation of IL-15 induction by rhino...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2011-07-01
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| Series: | PLoS Pathogens |
| Online Access: | http://europepmc.org/articles/PMC3136447?pdf=render |
| _version_ | 1817990726505463808 |
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| author | Vasile Laza-Stanca Simon D Message Michael R Edwards Hayley L Parker Mihnea T Zdrenghea Tatiana Kebadze Onn M Kon Patrick Mallia Luminita A Stanciu Sebastian L Johnston |
| author_facet | Vasile Laza-Stanca Simon D Message Michael R Edwards Hayley L Parker Mihnea T Zdrenghea Tatiana Kebadze Onn M Kon Patrick Mallia Luminita A Stanciu Sebastian L Johnston |
| author_sort | Vasile Laza-Stanca |
| collection | DOAJ |
| description | Rhinovirus infections are the major cause of asthma exacerbations. We hypothesised that IL-15, a cytokine implicated in innate and acquired antiviral immunity, may be deficient in asthma and important in the pathogenesis of asthma exacerbations. We investigated regulation of IL-15 induction by rhinovirus in human macrophages in vitro, IL-15 levels in bronchoalveolar lavage (BAL) fluid and IL-15 induction by rhinovirus in BAL macrophages from asthmatic and control subjects, and related these to outcomes of infection in vivo. Rhinovirus induced IL-15 in macrophages was replication-, NF-κB- and α/β interferon-dependent. BAL macrophage IL-15 induction by rhinovirus was impaired in asthmatics and inversely related to lower respiratory symptom severity during experimental rhinovirus infection. IL-15 levels in BAL fluid were also decreased in asthmatics and inversely related with airway hyperresponsiveness and with virus load during in vivo rhinovirus infection. Deficient IL-15 production in asthma may be important in the pathogenesis of asthma exacerbations. |
| first_indexed | 2024-04-14T01:03:47Z |
| format | Article |
| id | doaj.art-e9e8861e165547c4b6caaaf773a7fc0f |
| institution | Directory Open Access Journal |
| issn | 1553-7366 1553-7374 |
| language | English |
| last_indexed | 2024-04-14T01:03:47Z |
| publishDate | 2011-07-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Pathogens |
| spelling | doaj.art-e9e8861e165547c4b6caaaf773a7fc0f2022-12-22T02:21:20ZengPublic Library of Science (PLoS)PLoS Pathogens1553-73661553-73742011-07-0177e100211410.1371/journal.ppat.1002114The role of IL-15 deficiency in the pathogenesis of virus-induced asthma exacerbations.Vasile Laza-StancaSimon D MessageMichael R EdwardsHayley L ParkerMihnea T ZdrengheaTatiana KebadzeOnn M KonPatrick MalliaLuminita A StanciuSebastian L JohnstonRhinovirus infections are the major cause of asthma exacerbations. We hypothesised that IL-15, a cytokine implicated in innate and acquired antiviral immunity, may be deficient in asthma and important in the pathogenesis of asthma exacerbations. We investigated regulation of IL-15 induction by rhinovirus in human macrophages in vitro, IL-15 levels in bronchoalveolar lavage (BAL) fluid and IL-15 induction by rhinovirus in BAL macrophages from asthmatic and control subjects, and related these to outcomes of infection in vivo. Rhinovirus induced IL-15 in macrophages was replication-, NF-κB- and α/β interferon-dependent. BAL macrophage IL-15 induction by rhinovirus was impaired in asthmatics and inversely related to lower respiratory symptom severity during experimental rhinovirus infection. IL-15 levels in BAL fluid were also decreased in asthmatics and inversely related with airway hyperresponsiveness and with virus load during in vivo rhinovirus infection. Deficient IL-15 production in asthma may be important in the pathogenesis of asthma exacerbations.http://europepmc.org/articles/PMC3136447?pdf=render |
| spellingShingle | Vasile Laza-Stanca Simon D Message Michael R Edwards Hayley L Parker Mihnea T Zdrenghea Tatiana Kebadze Onn M Kon Patrick Mallia Luminita A Stanciu Sebastian L Johnston The role of IL-15 deficiency in the pathogenesis of virus-induced asthma exacerbations. PLoS Pathogens |
| title | The role of IL-15 deficiency in the pathogenesis of virus-induced asthma exacerbations. |
| title_full | The role of IL-15 deficiency in the pathogenesis of virus-induced asthma exacerbations. |
| title_fullStr | The role of IL-15 deficiency in the pathogenesis of virus-induced asthma exacerbations. |
| title_full_unstemmed | The role of IL-15 deficiency in the pathogenesis of virus-induced asthma exacerbations. |
| title_short | The role of IL-15 deficiency in the pathogenesis of virus-induced asthma exacerbations. |
| title_sort | role of il 15 deficiency in the pathogenesis of virus induced asthma exacerbations |
| url | http://europepmc.org/articles/PMC3136447?pdf=render |
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