Effect of exercise training on cardiac mitochondrial respiration, biogenesis, dynamics, and mitophagy in ischemic heart disease
ObjectiveCardiac mitochondrial dysfunction was found in ischemic heart disease (IHD). Hence, this study determined the effects of exercise training (ET) on cardiac mitochondrial respiration and cardiac mitochondrial quality control in IHD.MethodsA narrative synthesis was conducted after searching an...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-10-01
|
| Series: | Frontiers in Cardiovascular Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2022.949744/full |
| _version_ | 1811241224978300928 |
|---|---|
| author | Mary Audrey D. Viloria Mary Audrey D. Viloria Qing Li Wang Lu Nguyen Thanh Nhu Yijie Liu Yijie Liu Zhen-Yang Cui Yu-Jung Cheng Shin-Da Lee Shin-Da Lee Shin-Da Lee |
| author_facet | Mary Audrey D. Viloria Mary Audrey D. Viloria Qing Li Wang Lu Nguyen Thanh Nhu Yijie Liu Yijie Liu Zhen-Yang Cui Yu-Jung Cheng Shin-Da Lee Shin-Da Lee Shin-Da Lee |
| author_sort | Mary Audrey D. Viloria |
| collection | DOAJ |
| description | ObjectiveCardiac mitochondrial dysfunction was found in ischemic heart disease (IHD). Hence, this study determined the effects of exercise training (ET) on cardiac mitochondrial respiration and cardiac mitochondrial quality control in IHD.MethodsA narrative synthesis was conducted after searching animal studies written in English in three databases (PubMed, Web of Science, and EMBASE) until December 2020. Studies that used aerobic exercise as an intervention for at least 3 weeks and had at least normal, negative (sedentary IHD), and positive (exercise-trained IHD) groups were included. The CAMARADES checklist was used to check the quality of the included studies.ResultsThe 10 included studies (CAMARADES score: 6–7/10) used swimming or treadmill exercise for 3–8 weeks. Seven studies showed that ET ameliorated cardiac mitochondrial respiratory function as manifested by decreased reactive oxygen species (ROS) production and increased complexes I-V activity, superoxide dismutase 2 (SOD2), respiratory control ratio (RCR), NADH dehydrogenase subunits 1 and 6 (ND1/6), Cytochrome B (CytB), and adenosine triphosphate (ATP) production. Ten studies showed that ET improved cardiac mitochondrial quality control in IHD as manifested by enhanced and/or controlled mitochondrial biogenesis, dynamics, and mitophagy. Four other studies showed that ET resulted in better cardiac mitochondrial physiological characteristics.ConclusionExercise training could improve cardiac mitochondrial functions, including respiration, biogenesis, dynamics, and mitophagy in IHD.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=226817, identifier: CRD42021226817. |
| first_indexed | 2024-04-12T13:33:18Z |
| format | Article |
| id | doaj.art-e9eaeaf8011a4ab9a404168dd1489dac |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-04-12T13:33:18Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-e9eaeaf8011a4ab9a404168dd1489dac2022-12-22T03:31:07ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2022-10-01910.3389/fcvm.2022.949744949744Effect of exercise training on cardiac mitochondrial respiration, biogenesis, dynamics, and mitophagy in ischemic heart diseaseMary Audrey D. Viloria0Mary Audrey D. Viloria1Qing Li2Wang Lu3Nguyen Thanh Nhu4Yijie Liu5Yijie Liu6Zhen-Yang Cui7Yu-Jung Cheng8Shin-Da Lee9Shin-Da Lee10Shin-Da Lee11Department of Physical Therapy, Graduate Institute of Rehabilitation Science, China Medical University, Taichung, TaiwanDepartment of Physical Therapy, College of Health Sciences, Mariano Marcos State University, Batac, PhilippinesDepartment of Rehabilitation, Shanghai Xuhui Central Hospital, Shanghai, ChinaDepartment of Traditional Treatment, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaFaculty of Medicine, Can Tho University of Medicine and Pharmacy, Can Tho, VietnamSchool of Rehabilitation Medicine, Shanghai University of Traditional Medicine, Shanghai, ChinaInstitute of Rehabilitation Medicine, Shanghai University of Traditional Medicine, Shanghai, ChinaSchool of Rehabilitation Medicine, Weifang Medical University, Weifang, ChinaDepartment of Physical Therapy, Graduate Institute of Rehabilitation Science, China Medical University, Taichung, TaiwanDepartment of Physical Therapy, Graduate Institute of Rehabilitation Science, China Medical University, Taichung, TaiwanSchool of Rehabilitation Medicine, Weifang Medical University, Weifang, ChinaDepartment of Physical Therapy, Asia University, Taichung, TaiwanObjectiveCardiac mitochondrial dysfunction was found in ischemic heart disease (IHD). Hence, this study determined the effects of exercise training (ET) on cardiac mitochondrial respiration and cardiac mitochondrial quality control in IHD.MethodsA narrative synthesis was conducted after searching animal studies written in English in three databases (PubMed, Web of Science, and EMBASE) until December 2020. Studies that used aerobic exercise as an intervention for at least 3 weeks and had at least normal, negative (sedentary IHD), and positive (exercise-trained IHD) groups were included. The CAMARADES checklist was used to check the quality of the included studies.ResultsThe 10 included studies (CAMARADES score: 6–7/10) used swimming or treadmill exercise for 3–8 weeks. Seven studies showed that ET ameliorated cardiac mitochondrial respiratory function as manifested by decreased reactive oxygen species (ROS) production and increased complexes I-V activity, superoxide dismutase 2 (SOD2), respiratory control ratio (RCR), NADH dehydrogenase subunits 1 and 6 (ND1/6), Cytochrome B (CytB), and adenosine triphosphate (ATP) production. Ten studies showed that ET improved cardiac mitochondrial quality control in IHD as manifested by enhanced and/or controlled mitochondrial biogenesis, dynamics, and mitophagy. Four other studies showed that ET resulted in better cardiac mitochondrial physiological characteristics.ConclusionExercise training could improve cardiac mitochondrial functions, including respiration, biogenesis, dynamics, and mitophagy in IHD.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=226817, identifier: CRD42021226817.https://www.frontiersin.org/articles/10.3389/fcvm.2022.949744/fullischemic heart diseaseexercise trainingmitochondriacardioprotectionintervention |
| spellingShingle | Mary Audrey D. Viloria Mary Audrey D. Viloria Qing Li Wang Lu Nguyen Thanh Nhu Yijie Liu Yijie Liu Zhen-Yang Cui Yu-Jung Cheng Shin-Da Lee Shin-Da Lee Shin-Da Lee Effect of exercise training on cardiac mitochondrial respiration, biogenesis, dynamics, and mitophagy in ischemic heart disease Frontiers in Cardiovascular Medicine ischemic heart disease exercise training mitochondria cardioprotection intervention |
| title | Effect of exercise training on cardiac mitochondrial respiration, biogenesis, dynamics, and mitophagy in ischemic heart disease |
| title_full | Effect of exercise training on cardiac mitochondrial respiration, biogenesis, dynamics, and mitophagy in ischemic heart disease |
| title_fullStr | Effect of exercise training on cardiac mitochondrial respiration, biogenesis, dynamics, and mitophagy in ischemic heart disease |
| title_full_unstemmed | Effect of exercise training on cardiac mitochondrial respiration, biogenesis, dynamics, and mitophagy in ischemic heart disease |
| title_short | Effect of exercise training on cardiac mitochondrial respiration, biogenesis, dynamics, and mitophagy in ischemic heart disease |
| title_sort | effect of exercise training on cardiac mitochondrial respiration biogenesis dynamics and mitophagy in ischemic heart disease |
| topic | ischemic heart disease exercise training mitochondria cardioprotection intervention |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2022.949744/full |
| work_keys_str_mv | AT maryaudreydviloria effectofexercisetrainingoncardiacmitochondrialrespirationbiogenesisdynamicsandmitophagyinischemicheartdisease AT maryaudreydviloria effectofexercisetrainingoncardiacmitochondrialrespirationbiogenesisdynamicsandmitophagyinischemicheartdisease AT qingli effectofexercisetrainingoncardiacmitochondrialrespirationbiogenesisdynamicsandmitophagyinischemicheartdisease AT wanglu effectofexercisetrainingoncardiacmitochondrialrespirationbiogenesisdynamicsandmitophagyinischemicheartdisease AT nguyenthanhnhu effectofexercisetrainingoncardiacmitochondrialrespirationbiogenesisdynamicsandmitophagyinischemicheartdisease AT yijieliu effectofexercisetrainingoncardiacmitochondrialrespirationbiogenesisdynamicsandmitophagyinischemicheartdisease AT yijieliu effectofexercisetrainingoncardiacmitochondrialrespirationbiogenesisdynamicsandmitophagyinischemicheartdisease AT zhenyangcui effectofexercisetrainingoncardiacmitochondrialrespirationbiogenesisdynamicsandmitophagyinischemicheartdisease AT yujungcheng effectofexercisetrainingoncardiacmitochondrialrespirationbiogenesisdynamicsandmitophagyinischemicheartdisease AT shindalee effectofexercisetrainingoncardiacmitochondrialrespirationbiogenesisdynamicsandmitophagyinischemicheartdisease AT shindalee effectofexercisetrainingoncardiacmitochondrialrespirationbiogenesisdynamicsandmitophagyinischemicheartdisease AT shindalee effectofexercisetrainingoncardiacmitochondrialrespirationbiogenesisdynamicsandmitophagyinischemicheartdisease |