Tracing the evolution of tissue inhibitor of metalloproteinases in Metazoa with the Pteria penguin genome
Summary: Tissue inhibitors of metalloproteinase (TIMPs) play a pivotal role in regulating extracellular matrix (ECM) dynamics and have been extensively studied in vertebrates. However, understanding their evolution across invertebrate phyla is limited. Utilizing the high-quality Pteria penguin genom...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-01-01
|
| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004223026561 |
| _version_ | 1797398600895954944 |
|---|---|
| author | Chao-Yi Ma Yi Chen Xin Zhan Yun-Wei Dong |
| author_facet | Chao-Yi Ma Yi Chen Xin Zhan Yun-Wei Dong |
| author_sort | Chao-Yi Ma |
| collection | DOAJ |
| description | Summary: Tissue inhibitors of metalloproteinase (TIMPs) play a pivotal role in regulating extracellular matrix (ECM) dynamics and have been extensively studied in vertebrates. However, understanding their evolution across invertebrate phyla is limited. Utilizing the high-quality Pteria penguin genome, we conducted phylogenomic orthology analyses across metazoans, revealing the emergence and distribution of the TIMP gene family. Our findings show that TIMP repertoires originated during eumetazoan radiation, experiencing independent duplication events in different clades, resulting in varied family sizes. Particularly, Pteriomorphia bivalves within Mollusca exhibited the most significant expansion and displayed the most diverse TIMP repertoires among metazoans. These expansions were attributed to multiple gene duplication events, potentially driven by the demands for functional diversification related to multiple adaptive traits, contributing to the adaptation of Pteriomorphia bivalves as stationary filter feeders. In this context, Pteriomorphia bivalves offer a promising model for studying invertebrate TIMP evolution. |
| first_indexed | 2024-03-09T01:27:54Z |
| format | Article |
| id | doaj.art-e9eaf74f8b7b411f938b3b0216aa80f2 |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-03-09T01:27:54Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-e9eaf74f8b7b411f938b3b0216aa80f22023-12-10T06:16:58ZengElsevieriScience2589-00422024-01-01271108579Tracing the evolution of tissue inhibitor of metalloproteinases in Metazoa with the Pteria penguin genomeChao-Yi Ma0Yi Chen1Xin Zhan2Yun-Wei Dong3Key Laboratory of Mariculture, Ministry of Education, Fisheries College, Ocean University of China, Qingdao 266003, P.R. China; Academy of the Future Ocean, Ocean University of China, Qingdao 266100, P.R. ChinaState Key Laboratory of Marine Resources Utilization in South China Sea, Hainan University, Haikou 570228, P.R. China; School of Marine Biology and Fisheries, Hainan University, Haikou 570228, P.R. ChinaState Key Laboratory of Marine Resources Utilization in South China Sea, Hainan University, Haikou 570228, P.R. China; School of Marine Biology and Fisheries, Hainan University, Haikou 570228, P.R. China; Corresponding authorKey Laboratory of Mariculture, Ministry of Education, Fisheries College, Ocean University of China, Qingdao 266003, P.R. China; Academy of the Future Ocean, Ocean University of China, Qingdao 266100, P.R. China; Corresponding authorSummary: Tissue inhibitors of metalloproteinase (TIMPs) play a pivotal role in regulating extracellular matrix (ECM) dynamics and have been extensively studied in vertebrates. However, understanding their evolution across invertebrate phyla is limited. Utilizing the high-quality Pteria penguin genome, we conducted phylogenomic orthology analyses across metazoans, revealing the emergence and distribution of the TIMP gene family. Our findings show that TIMP repertoires originated during eumetazoan radiation, experiencing independent duplication events in different clades, resulting in varied family sizes. Particularly, Pteriomorphia bivalves within Mollusca exhibited the most significant expansion and displayed the most diverse TIMP repertoires among metazoans. These expansions were attributed to multiple gene duplication events, potentially driven by the demands for functional diversification related to multiple adaptive traits, contributing to the adaptation of Pteriomorphia bivalves as stationary filter feeders. In this context, Pteriomorphia bivalves offer a promising model for studying invertebrate TIMP evolution.http://www.sciencedirect.com/science/article/pii/S2589004223026561ZoologyEvolutionary biologyPhylogeny |
| spellingShingle | Chao-Yi Ma Yi Chen Xin Zhan Yun-Wei Dong Tracing the evolution of tissue inhibitor of metalloproteinases in Metazoa with the Pteria penguin genome iScience Zoology Evolutionary biology Phylogeny |
| title | Tracing the evolution of tissue inhibitor of metalloproteinases in Metazoa with the Pteria penguin genome |
| title_full | Tracing the evolution of tissue inhibitor of metalloproteinases in Metazoa with the Pteria penguin genome |
| title_fullStr | Tracing the evolution of tissue inhibitor of metalloproteinases in Metazoa with the Pteria penguin genome |
| title_full_unstemmed | Tracing the evolution of tissue inhibitor of metalloproteinases in Metazoa with the Pteria penguin genome |
| title_short | Tracing the evolution of tissue inhibitor of metalloproteinases in Metazoa with the Pteria penguin genome |
| title_sort | tracing the evolution of tissue inhibitor of metalloproteinases in metazoa with the pteria penguin genome |
| topic | Zoology Evolutionary biology Phylogeny |
| url | http://www.sciencedirect.com/science/article/pii/S2589004223026561 |
| work_keys_str_mv | AT chaoyima tracingtheevolutionoftissueinhibitorofmetalloproteinasesinmetazoawiththepteriapenguingenome AT yichen tracingtheevolutionoftissueinhibitorofmetalloproteinasesinmetazoawiththepteriapenguingenome AT xinzhan tracingtheevolutionoftissueinhibitorofmetalloproteinasesinmetazoawiththepteriapenguingenome AT yunweidong tracingtheevolutionoftissueinhibitorofmetalloproteinasesinmetazoawiththepteriapenguingenome |