The Transmembrane Protease TMPRSS2 as a Therapeutic Target for COVID-19 Treatment
TMPRSS2 is a type II transmembrane protease with broad expression in epithelial cells of the respiratory and gastrointestinal tract, the prostate, and other organs. Although the physiological role of TMPRSS2 remains largely elusive, several endogenous substrates have been identified. TMPRSS2 serves...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-01-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/23/3/1351 |
| _version_ | 1797487477570666496 |
|---|---|
| author | Lukas Wettstein Frank Kirchhoff Jan Münch |
| author_facet | Lukas Wettstein Frank Kirchhoff Jan Münch |
| author_sort | Lukas Wettstein |
| collection | DOAJ |
| description | TMPRSS2 is a type II transmembrane protease with broad expression in epithelial cells of the respiratory and gastrointestinal tract, the prostate, and other organs. Although the physiological role of TMPRSS2 remains largely elusive, several endogenous substrates have been identified. TMPRSS2 serves as a major cofactor in SARS-CoV-2 entry, and primes glycoproteins of other respiratory viruses as well. Consequently, inhibiting TMPRSS2 activity is a promising strategy to block viral infection. In this review, we provide an overview of the role of TMPRSS2 in the entry processes of different respiratory viruses. We then review the different classes of TMPRSS2 inhibitors and their clinical development, with a focus on COVID-19 treatment. |
| first_indexed | 2024-03-09T23:49:11Z |
| format | Article |
| id | doaj.art-e9ed1f9e875f4d2e8e360b3ef0634e21 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T23:49:11Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-e9ed1f9e875f4d2e8e360b3ef0634e212023-11-23T16:39:02ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-01-01233135110.3390/ijms23031351The Transmembrane Protease TMPRSS2 as a Therapeutic Target for COVID-19 TreatmentLukas Wettstein0Frank Kirchhoff1Jan Münch2Institute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, GermanyInstitute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, GermanyInstitute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, GermanyTMPRSS2 is a type II transmembrane protease with broad expression in epithelial cells of the respiratory and gastrointestinal tract, the prostate, and other organs. Although the physiological role of TMPRSS2 remains largely elusive, several endogenous substrates have been identified. TMPRSS2 serves as a major cofactor in SARS-CoV-2 entry, and primes glycoproteins of other respiratory viruses as well. Consequently, inhibiting TMPRSS2 activity is a promising strategy to block viral infection. In this review, we provide an overview of the role of TMPRSS2 in the entry processes of different respiratory viruses. We then review the different classes of TMPRSS2 inhibitors and their clinical development, with a focus on COVID-19 treatment.https://www.mdpi.com/1422-0067/23/3/1351TMPRSS2coronavirusSARS-CoV-2influenzaprotease inhibitor |
| spellingShingle | Lukas Wettstein Frank Kirchhoff Jan Münch The Transmembrane Protease TMPRSS2 as a Therapeutic Target for COVID-19 Treatment International Journal of Molecular Sciences TMPRSS2 coronavirus SARS-CoV-2 influenza protease inhibitor |
| title | The Transmembrane Protease TMPRSS2 as a Therapeutic Target for COVID-19 Treatment |
| title_full | The Transmembrane Protease TMPRSS2 as a Therapeutic Target for COVID-19 Treatment |
| title_fullStr | The Transmembrane Protease TMPRSS2 as a Therapeutic Target for COVID-19 Treatment |
| title_full_unstemmed | The Transmembrane Protease TMPRSS2 as a Therapeutic Target for COVID-19 Treatment |
| title_short | The Transmembrane Protease TMPRSS2 as a Therapeutic Target for COVID-19 Treatment |
| title_sort | transmembrane protease tmprss2 as a therapeutic target for covid 19 treatment |
| topic | TMPRSS2 coronavirus SARS-CoV-2 influenza protease inhibitor |
| url | https://www.mdpi.com/1422-0067/23/3/1351 |
| work_keys_str_mv | AT lukaswettstein thetransmembraneproteasetmprss2asatherapeutictargetforcovid19treatment AT frankkirchhoff thetransmembraneproteasetmprss2asatherapeutictargetforcovid19treatment AT janmunch thetransmembraneproteasetmprss2asatherapeutictargetforcovid19treatment AT lukaswettstein transmembraneproteasetmprss2asatherapeutictargetforcovid19treatment AT frankkirchhoff transmembraneproteasetmprss2asatherapeutictargetforcovid19treatment AT janmunch transmembraneproteasetmprss2asatherapeutictargetforcovid19treatment |