The Specific Features of Artificial Ventilation in Premature Neonates with Acute Respiratory Distress Syndrome
Objective: to evaluate the efficiency of artificial ventilation (AV) after administration of the exogenous surfactants Curosurf and Surfactant BL in premature neonates with respiratory distress syndrome (RSD). Subjects and methods. The paper presents the results of evaluation of the efficiency of th...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia
2010-02-01
|
| Series: | Общая реаниматология |
| Online Access: | https://www.reanimatology.com/rmt/article/view/498 |
| _version_ | 1826562329698893824 |
|---|---|
| author | S. A. Perepelitsa A. M. Golubev V. V. Moroz |
| author_facet | S. A. Perepelitsa A. M. Golubev V. V. Moroz |
| author_sort | S. A. Perepelitsa |
| collection | DOAJ |
| description | Objective: to evaluate the efficiency of artificial ventilation (AV) after administration of the exogenous surfactants Curosurf and Surfactant BL in premature neonates with respiratory distress syndrome (RSD). Subjects and methods. The paper presents the results of evaluation of the efficiency of therapy with exogenous surfactants, by examining the blood gas composition and AV parameters. The study included 122 premature neonates with severe RSD. According to the type of a used surfactant, two groups of neonates were identified: Group 1 comprised 67 neonates who were given Curosurf and Group 2 consisted of 55 neonates who had Surfactant BL. Results. The study has revealed some differences between the drugs. Four hours after administration of Curosurf, the neonates with RSD showed heterodirectional changes in partial blood oxygen tension; no abnormal changes in this index were found in most neonates; however, hyperoxia or hypoxia appeared in some newborn infants. After administration of Surfactant BL, no hyperoxia was virtually detected. Hyperoxia did not depend on the baseline oxygen fraction in the inspired gas mixture in most cases. The found changes were transient. To choose ventilation parameters was based on an attempt to bring partial blood oxygen tension closer to the normal values. The main task of the treatment was achieved: this was to carry out sparing AV in premature neonates, allowing no mechanical injury to the immature lung or ventilation complications. Conclusion. pO2 variability after administration of exogenous surfactants calls for a considerate attitude to the choice of AV parameters and an individual approach to a patient. The specific features of the pharmacological action of exogenous surfactants should be taken into account when they are used. In this connection, blood gas composition should be frequently investigated – particularly within the first 24 hours after administration of the agents in order to timely modify AV parameters. |
| first_indexed | 2024-04-10T01:29:54Z |
| format | Article |
| id | doaj.art-e9eea9016bf648fa934a36bc36dc45e1 |
| institution | Directory Open Access Journal |
| issn | 1813-9779 2411-7110 |
| language | English |
| last_indexed | 2025-03-14T09:46:21Z |
| publishDate | 2010-02-01 |
| publisher | Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia |
| record_format | Article |
| series | Общая реаниматология |
| spelling | doaj.art-e9eea9016bf648fa934a36bc36dc45e12025-03-02T11:29:30ZengFederal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, RussiaОбщая реаниматология1813-97792411-71102010-02-016110.15360/1813-9779-2010-1-11498The Specific Features of Artificial Ventilation in Premature Neonates with Acute Respiratory Distress SyndromeS. A. PerepelitsaA. M. GolubevV. V. MorozObjective: to evaluate the efficiency of artificial ventilation (AV) after administration of the exogenous surfactants Curosurf and Surfactant BL in premature neonates with respiratory distress syndrome (RSD). Subjects and methods. The paper presents the results of evaluation of the efficiency of therapy with exogenous surfactants, by examining the blood gas composition and AV parameters. The study included 122 premature neonates with severe RSD. According to the type of a used surfactant, two groups of neonates were identified: Group 1 comprised 67 neonates who were given Curosurf and Group 2 consisted of 55 neonates who had Surfactant BL. Results. The study has revealed some differences between the drugs. Four hours after administration of Curosurf, the neonates with RSD showed heterodirectional changes in partial blood oxygen tension; no abnormal changes in this index were found in most neonates; however, hyperoxia or hypoxia appeared in some newborn infants. After administration of Surfactant BL, no hyperoxia was virtually detected. Hyperoxia did not depend on the baseline oxygen fraction in the inspired gas mixture in most cases. The found changes were transient. To choose ventilation parameters was based on an attempt to bring partial blood oxygen tension closer to the normal values. The main task of the treatment was achieved: this was to carry out sparing AV in premature neonates, allowing no mechanical injury to the immature lung or ventilation complications. Conclusion. pO2 variability after administration of exogenous surfactants calls for a considerate attitude to the choice of AV parameters and an individual approach to a patient. The specific features of the pharmacological action of exogenous surfactants should be taken into account when they are used. In this connection, blood gas composition should be frequently investigated – particularly within the first 24 hours after administration of the agents in order to timely modify AV parameters.https://www.reanimatology.com/rmt/article/view/498 |
| spellingShingle | S. A. Perepelitsa A. M. Golubev V. V. Moroz The Specific Features of Artificial Ventilation in Premature Neonates with Acute Respiratory Distress Syndrome Общая реаниматология |
| title | The Specific Features of Artificial Ventilation in Premature Neonates with Acute Respiratory Distress Syndrome |
| title_full | The Specific Features of Artificial Ventilation in Premature Neonates with Acute Respiratory Distress Syndrome |
| title_fullStr | The Specific Features of Artificial Ventilation in Premature Neonates with Acute Respiratory Distress Syndrome |
| title_full_unstemmed | The Specific Features of Artificial Ventilation in Premature Neonates with Acute Respiratory Distress Syndrome |
| title_short | The Specific Features of Artificial Ventilation in Premature Neonates with Acute Respiratory Distress Syndrome |
| title_sort | specific features of artificial ventilation in premature neonates with acute respiratory distress syndrome |
| url | https://www.reanimatology.com/rmt/article/view/498 |
| work_keys_str_mv | AT saperepelitsa thespecificfeaturesofartificialventilationinprematureneonateswithacuterespiratorydistresssyndrome AT amgolubev thespecificfeaturesofartificialventilationinprematureneonateswithacuterespiratorydistresssyndrome AT vvmoroz thespecificfeaturesofartificialventilationinprematureneonateswithacuterespiratorydistresssyndrome AT saperepelitsa specificfeaturesofartificialventilationinprematureneonateswithacuterespiratorydistresssyndrome AT amgolubev specificfeaturesofartificialventilationinprematureneonateswithacuterespiratorydistresssyndrome AT vvmoroz specificfeaturesofartificialventilationinprematureneonateswithacuterespiratorydistresssyndrome |