LPIN1 Induces Gefitinib Resistance in EGFR Inhibitor-Resistant Non-Small Cell Lung Cancer Cells

LPIN1 Induces Gefitinib Resistance in EGFR Inhibitor-Resistant Non-Small Cell Lung Cancer Cells

Drug resistance limits the efficacy of targeted therapies, including tyrosine kinase inhibitors (TKIs); however, a substantial portion of the drug resistance mechanisms remains unexplained. In this study, we identified LPIN1 as a key factor that regulates gefitinib resistance in epidermal growth fac...

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Bibliographic Details
Main Authors: Jung Hee Cho, Yeon-Mi You, Han Koo, Dong Chul Lee, Young Il Yeom, Kyung Chan Park
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Cancers
Subjects:
LPIN1
tyrosine kinase inhibitors
gefitinib
drug resistance
non-small cell lung cancer
Online Access:https://www.mdpi.com/2072-6694/14/9/2222

Internet

https://www.mdpi.com/2072-6694/14/9/2222

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