Amino acid sequence alignment of vertebrate CAPN3/calpain-3/p94
CAPN3 is a calpain superfamily member that is predominantly expressed in skeletal muscle. So far, clear CAPN3 orthologs were found only in vertebrates. CAPN3 is a unique protease in that it undergoes extremely rapid and exhaustive autolysis and that autolyzed fragments spontaneously associate each o...
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| Format: | Article |
| Language: | English |
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Elsevier
2015-12-01
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| Series: | Data in Brief |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352340915002152 |
| _version_ | 1818116669592043520 |
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| author | Yasuko Ono Hiroyuki Sorimachi |
| author_facet | Yasuko Ono Hiroyuki Sorimachi |
| author_sort | Yasuko Ono |
| collection | DOAJ |
| description | CAPN3 is a calpain superfamily member that is predominantly expressed in skeletal muscle. So far, clear CAPN3 orthologs were found only in vertebrates. CAPN3 is a unique protease in that it undergoes extremely rapid and exhaustive autolysis and that autolyzed fragments spontaneously associate each other to reconstitute the proteolytic activity. These unique properties of CAPN3 are dependent on IS1 and IS2, two CAPN3-characterizing sequences that do not exist in other calpains or any other proteases. To understand how IS1 and IS2 are conserved among vertebrates, this data article provides amino acid sequence alignment of representative vertebrate CAPN3s. For further analysis and discussion, see Ono et al. [1] |
| first_indexed | 2024-12-11T04:26:12Z |
| format | Article |
| id | doaj.art-e9f1e281a8184c9b98196e42998eb8e2 |
| institution | Directory Open Access Journal |
| issn | 2352-3409 |
| language | English |
| last_indexed | 2024-12-11T04:26:12Z |
| publishDate | 2015-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Data in Brief |
| spelling | doaj.art-e9f1e281a8184c9b98196e42998eb8e22022-12-22T01:20:58ZengElsevierData in Brief2352-34092015-12-015C36636710.1016/j.dib.2015.09.021Amino acid sequence alignment of vertebrate CAPN3/calpain-3/p94Yasuko OnoHiroyuki SorimachiCAPN3 is a calpain superfamily member that is predominantly expressed in skeletal muscle. So far, clear CAPN3 orthologs were found only in vertebrates. CAPN3 is a unique protease in that it undergoes extremely rapid and exhaustive autolysis and that autolyzed fragments spontaneously associate each other to reconstitute the proteolytic activity. These unique properties of CAPN3 are dependent on IS1 and IS2, two CAPN3-characterizing sequences that do not exist in other calpains or any other proteases. To understand how IS1 and IS2 are conserved among vertebrates, this data article provides amino acid sequence alignment of representative vertebrate CAPN3s. For further analysis and discussion, see Ono et al. [1]http://www.sciencedirect.com/science/article/pii/S2352340915002152 |
| spellingShingle | Yasuko Ono Hiroyuki Sorimachi Amino acid sequence alignment of vertebrate CAPN3/calpain-3/p94 Data in Brief |
| title | Amino acid sequence alignment of vertebrate CAPN3/calpain-3/p94 |
| title_full | Amino acid sequence alignment of vertebrate CAPN3/calpain-3/p94 |
| title_fullStr | Amino acid sequence alignment of vertebrate CAPN3/calpain-3/p94 |
| title_full_unstemmed | Amino acid sequence alignment of vertebrate CAPN3/calpain-3/p94 |
| title_short | Amino acid sequence alignment of vertebrate CAPN3/calpain-3/p94 |
| title_sort | amino acid sequence alignment of vertebrate capn3 calpain 3 p94 |
| url | http://www.sciencedirect.com/science/article/pii/S2352340915002152 |
| work_keys_str_mv | AT yasukoono aminoacidsequencealignmentofvertebratecapn3calpain3p94 AT hiroyukisorimachi aminoacidsequencealignmentofvertebratecapn3calpain3p94 |