Viral coinfection promotes tuberculosis immunopathogenesis by type I IFN signaling-dependent impediment of Th1 cell pulmonary influx
Viral coinfection alongside mycobacterium tuberculosis (Mtb) infection may lead to immune complications or interference with immune responses. Here the authors show that in mice infected with Mtb and LCMV virus the specific TH1 response to MTb is reduced through a type I IFN response to the infectin...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-06-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-30914-3 |
| _version_ | 1811248107465211904 |
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| author | Tae Gun Kang Kee Woong Kwon Kyungsoo Kim Insuk Lee Myeong Joon Kim Sang-Jun Ha Sung Jae Shin |
| author_facet | Tae Gun Kang Kee Woong Kwon Kyungsoo Kim Insuk Lee Myeong Joon Kim Sang-Jun Ha Sung Jae Shin |
| author_sort | Tae Gun Kang |
| collection | DOAJ |
| description | Viral coinfection alongside mycobacterium tuberculosis (Mtb) infection may lead to immune complications or interference with immune responses. Here the authors show that in mice infected with Mtb and LCMV virus the specific TH1 response to MTb is reduced through a type I IFN response to the infecting virus. |
| first_indexed | 2024-04-12T15:21:10Z |
| format | Article |
| id | doaj.art-e9f3bc112bd94dec938789f5b164586c |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-12T15:21:10Z |
| publishDate | 2022-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-e9f3bc112bd94dec938789f5b164586c2022-12-22T03:27:27ZengNature PortfolioNature Communications2041-17232022-06-0113111910.1038/s41467-022-30914-3Viral coinfection promotes tuberculosis immunopathogenesis by type I IFN signaling-dependent impediment of Th1 cell pulmonary influxTae Gun Kang0Kee Woong Kwon1Kyungsoo Kim2Insuk Lee3Myeong Joon Kim4Sang-Jun Ha5Sung Jae Shin6Department of Biochemistry, College of Life Science & Biotechnology, Yonsei UniversityDepartment of Microbiology, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of MedicineDepartment of Biochemistry, College of Life Science & Biotechnology, Yonsei UniversityDepartment of Biotechnology, College of Life Science & Biotechnology, Yonsei UniversityDepartment of Biochemistry, College of Life Science & Biotechnology, Yonsei UniversityDepartment of Biochemistry, College of Life Science & Biotechnology, Yonsei UniversityDepartment of Microbiology, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of MedicineViral coinfection alongside mycobacterium tuberculosis (Mtb) infection may lead to immune complications or interference with immune responses. Here the authors show that in mice infected with Mtb and LCMV virus the specific TH1 response to MTb is reduced through a type I IFN response to the infecting virus.https://doi.org/10.1038/s41467-022-30914-3 |
| spellingShingle | Tae Gun Kang Kee Woong Kwon Kyungsoo Kim Insuk Lee Myeong Joon Kim Sang-Jun Ha Sung Jae Shin Viral coinfection promotes tuberculosis immunopathogenesis by type I IFN signaling-dependent impediment of Th1 cell pulmonary influx Nature Communications |
| title | Viral coinfection promotes tuberculosis immunopathogenesis by type I IFN signaling-dependent impediment of Th1 cell pulmonary influx |
| title_full | Viral coinfection promotes tuberculosis immunopathogenesis by type I IFN signaling-dependent impediment of Th1 cell pulmonary influx |
| title_fullStr | Viral coinfection promotes tuberculosis immunopathogenesis by type I IFN signaling-dependent impediment of Th1 cell pulmonary influx |
| title_full_unstemmed | Viral coinfection promotes tuberculosis immunopathogenesis by type I IFN signaling-dependent impediment of Th1 cell pulmonary influx |
| title_short | Viral coinfection promotes tuberculosis immunopathogenesis by type I IFN signaling-dependent impediment of Th1 cell pulmonary influx |
| title_sort | viral coinfection promotes tuberculosis immunopathogenesis by type i ifn signaling dependent impediment of th1 cell pulmonary influx |
| url | https://doi.org/10.1038/s41467-022-30914-3 |
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