Comparison of Interleukin-6 with Other Markers in Diagnosis of Ovarian Cancer
The lack of specific symptoms in ovarian cancer delays onset of the diagnostic process. Hence, most cases are recognized in late stages of the disease. The aim of this study was to confirm the role of Il-6 compared to other markers in diagnosis and survival in ovarian cancer. The database was collec...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/13/6/980 |
| _version_ | 1797593958499483648 |
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| author | Magdalena Bizoń Zofia Awiżeń-Panufnik Włodzimierz Sawicki |
| author_facet | Magdalena Bizoń Zofia Awiżeń-Panufnik Włodzimierz Sawicki |
| author_sort | Magdalena Bizoń |
| collection | DOAJ |
| description | The lack of specific symptoms in ovarian cancer delays onset of the diagnostic process. Hence, most cases are recognized in late stages of the disease. The aim of this study was to confirm the role of Il-6 compared to other markers in diagnosis and survival in ovarian cancer. The database was collected from 13 January 2021 to 15 February 2023. In total, 101 patients with pelvic tumors with a mean age of 57.86 ± 16.39 participated in the study. In every case, CA125, HE4, CEA, CA19-9, Il-6, C-reactive protein and procalcitonin measurements were taken. Patients with ovarian borderline tumor and metastatic ovarian tumors were excluded from further analysis. Statistically significant correlations were found between diagnosis of ovarian cancer and levels of CA125, HE4, CRP, PCT and Il-6. Comparison of Il-6 with other markers revealed that longer overall survival correlated with lower values of Il-6. In the case of a higher concentration of Il-6, OS and PFS were shorter. Sensitivity and specificity of Il-6 in diagnosis of ovarian cancer were 46.8% and 77.8%, respectively, while for CA125, CRP and PCT were 76.6% and 63%; 68% and 57.5%; 36% and 77%, respectively. More investigations are needed to identify the most specific and sensitive marker for ovarian cancer. |
| first_indexed | 2024-03-11T02:15:54Z |
| format | Article |
| id | doaj.art-e9f89328ca1c4947adb3492e1d44143b |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-11T02:15:54Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-e9f89328ca1c4947adb3492e1d44143b2023-11-18T11:11:25ZengMDPI AGJournal of Personalized Medicine2075-44262023-06-0113698010.3390/jpm13060980Comparison of Interleukin-6 with Other Markers in Diagnosis of Ovarian CancerMagdalena Bizoń0Zofia Awiżeń-Panufnik1Włodzimierz Sawicki2Chair and Department of Obstetrics, Gynecology and Gynecological Oncology, Medical University of Warsaw, 03-242 Warszawa, PolandChair and Department of Obstetrics, Gynecology and Gynecological Oncology, Medical University of Warsaw, 03-242 Warszawa, PolandChair and Department of Obstetrics, Gynecology and Gynecological Oncology, Medical University of Warsaw, 03-242 Warszawa, PolandThe lack of specific symptoms in ovarian cancer delays onset of the diagnostic process. Hence, most cases are recognized in late stages of the disease. The aim of this study was to confirm the role of Il-6 compared to other markers in diagnosis and survival in ovarian cancer. The database was collected from 13 January 2021 to 15 February 2023. In total, 101 patients with pelvic tumors with a mean age of 57.86 ± 16.39 participated in the study. In every case, CA125, HE4, CEA, CA19-9, Il-6, C-reactive protein and procalcitonin measurements were taken. Patients with ovarian borderline tumor and metastatic ovarian tumors were excluded from further analysis. Statistically significant correlations were found between diagnosis of ovarian cancer and levels of CA125, HE4, CRP, PCT and Il-6. Comparison of Il-6 with other markers revealed that longer overall survival correlated with lower values of Il-6. In the case of a higher concentration of Il-6, OS and PFS were shorter. Sensitivity and specificity of Il-6 in diagnosis of ovarian cancer were 46.8% and 77.8%, respectively, while for CA125, CRP and PCT were 76.6% and 63%; 68% and 57.5%; 36% and 77%, respectively. More investigations are needed to identify the most specific and sensitive marker for ovarian cancer.https://www.mdpi.com/2075-4426/13/6/980ovarian cancerdiagnosisinterleukin-6ovarian tumor markers |
| spellingShingle | Magdalena Bizoń Zofia Awiżeń-Panufnik Włodzimierz Sawicki Comparison of Interleukin-6 with Other Markers in Diagnosis of Ovarian Cancer Journal of Personalized Medicine ovarian cancer diagnosis interleukin-6 ovarian tumor markers |
| title | Comparison of Interleukin-6 with Other Markers in Diagnosis of Ovarian Cancer |
| title_full | Comparison of Interleukin-6 with Other Markers in Diagnosis of Ovarian Cancer |
| title_fullStr | Comparison of Interleukin-6 with Other Markers in Diagnosis of Ovarian Cancer |
| title_full_unstemmed | Comparison of Interleukin-6 with Other Markers in Diagnosis of Ovarian Cancer |
| title_short | Comparison of Interleukin-6 with Other Markers in Diagnosis of Ovarian Cancer |
| title_sort | comparison of interleukin 6 with other markers in diagnosis of ovarian cancer |
| topic | ovarian cancer diagnosis interleukin-6 ovarian tumor markers |
| url | https://www.mdpi.com/2075-4426/13/6/980 |
| work_keys_str_mv | AT magdalenabizon comparisonofinterleukin6withothermarkersindiagnosisofovariancancer AT zofiaawizenpanufnik comparisonofinterleukin6withothermarkersindiagnosisofovariancancer AT włodzimierzsawicki comparisonofinterleukin6withothermarkersindiagnosisofovariancancer |