Gel immersion endoscopic submucosal dissection: clinical experience with 13 cases of superficial esophageal cancer
Esophageal endoscopic submucosal dissection (ESD) of tumors located on the gravity side is technically challenging. Given that gel immersion ESD (GIESD) is performed by immersing lesions in gel, we hypothesized that it could be used to eliminate the disadvantage associated with submerging the gravit...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Georg Thieme Verlag KG
2022-09-01
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| Series: | Endoscopy International Open |
| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/a-1894-0719 |
| _version_ | 1811183635757268992 |
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| author | Yuya Nakano Tomoaki Tashima Ryuhei Jinushi Rie Terada Yumi Mashimo Tomonori Kawasaki Toshio Uraoka Shomei Ryozawa |
| author_facet | Yuya Nakano Tomoaki Tashima Ryuhei Jinushi Rie Terada Yumi Mashimo Tomonori Kawasaki Toshio Uraoka Shomei Ryozawa |
| author_sort | Yuya Nakano |
| collection | DOAJ |
| description | Esophageal endoscopic submucosal dissection (ESD) of tumors located on the gravity side is technically challenging. Given that gel immersion ESD (GIESD) is performed by immersing lesions in gel, we hypothesized that it could be used to eliminate the disadvantage associated with submerging the gravity side. Here, we performed GIESD using VISCOCLEAR for superficial esophageal cancer on the gravity side of the esophagus, with monopolar devices. This study aimed to evaluate the short-term outcomes of GIESD for superficial esophageal cancer. Fifteen patients with 16 superficial esophageal cancers underwent GIESD by a single operator, and 13 cases were evaluated. All patients were male, and GIESD was performed in the middle (12/13, 92.3 %) and lower (1/13, 7.7 %) thoracic esophagus. The lesions were located on the left (7/13, 53.8 %), posterior (5/13, 38.5 %), and right (1/13, 7.7 %) esophageal walls. The median procedure time was 27 minutes (interquartile range [IQR], 14–68), and the median dissection speed was 20 mm2/min (IQR, 14–25.7). The median amount of gel used was 400 mL (IQR, 360–580), and no gel-related adverse events were observed. The median total dose of midazolam was 3 mg (IQR, 2–5). GIESD was completed with en bloc and R0 resections achieved in 100 % of the 13 cases. Delayed adverse events, such as bleeding or perforation, did not occur (0/13, 0 %). |
| first_indexed | 2024-04-11T09:50:14Z |
| format | Article |
| id | doaj.art-e9fa7100a6894a2fbb4d8c3afed300ac |
| institution | Directory Open Access Journal |
| issn | 2364-3722 2196-9736 |
| language | English |
| last_indexed | 2024-04-11T09:50:14Z |
| publishDate | 2022-09-01 |
| publisher | Georg Thieme Verlag KG |
| record_format | Article |
| series | Endoscopy International Open |
| spelling | doaj.art-e9fa7100a6894a2fbb4d8c3afed300ac2022-12-22T04:30:51ZengGeorg Thieme Verlag KGEndoscopy International Open2364-37222196-97362022-09-011009E1302E130610.1055/a-1894-0719Gel immersion endoscopic submucosal dissection: clinical experience with 13 cases of superficial esophageal cancerYuya Nakano0Tomoaki Tashima1Ryuhei Jinushi2Rie Terada3Yumi Mashimo4Tomonori Kawasaki5Toshio Uraoka6Shomei Ryozawa7Department of Gastroenterology, Saitama Medical University International Medical Center, Saitama, JapanDepartment of Gastroenterology, Saitama Medical University International Medical Center, Saitama, JapanDepartment of Gastroenterology, Saitama Medical University International Medical Center, Saitama, JapanDepartment of Gastroenterology, Saitama Medical University International Medical Center, Saitama, JapanDepartment of Gastroenterology, Saitama Medical University International Medical Center, Saitama, JapanDepartment of Pathology, Saitama Medical University International Medical Center, Saitama, JapanDepartment of Gastroenterology and Hepatology, Graduate School of Medicine, Gunma University, Gunma, Japan.Department of Gastroenterology, Saitama Medical University International Medical Center, Saitama, JapanEsophageal endoscopic submucosal dissection (ESD) of tumors located on the gravity side is technically challenging. Given that gel immersion ESD (GIESD) is performed by immersing lesions in gel, we hypothesized that it could be used to eliminate the disadvantage associated with submerging the gravity side. Here, we performed GIESD using VISCOCLEAR for superficial esophageal cancer on the gravity side of the esophagus, with monopolar devices. This study aimed to evaluate the short-term outcomes of GIESD for superficial esophageal cancer. Fifteen patients with 16 superficial esophageal cancers underwent GIESD by a single operator, and 13 cases were evaluated. All patients were male, and GIESD was performed in the middle (12/13, 92.3 %) and lower (1/13, 7.7 %) thoracic esophagus. The lesions were located on the left (7/13, 53.8 %), posterior (5/13, 38.5 %), and right (1/13, 7.7 %) esophageal walls. The median procedure time was 27 minutes (interquartile range [IQR], 14–68), and the median dissection speed was 20 mm2/min (IQR, 14–25.7). The median amount of gel used was 400 mL (IQR, 360–580), and no gel-related adverse events were observed. The median total dose of midazolam was 3 mg (IQR, 2–5). GIESD was completed with en bloc and R0 resections achieved in 100 % of the 13 cases. Delayed adverse events, such as bleeding or perforation, did not occur (0/13, 0 %).http://www.thieme-connect.de/DOI/DOI?10.1055/a-1894-0719 |
| spellingShingle | Yuya Nakano Tomoaki Tashima Ryuhei Jinushi Rie Terada Yumi Mashimo Tomonori Kawasaki Toshio Uraoka Shomei Ryozawa Gel immersion endoscopic submucosal dissection: clinical experience with 13 cases of superficial esophageal cancer Endoscopy International Open |
| title | Gel immersion endoscopic submucosal dissection: clinical experience with 13 cases of superficial esophageal cancer |
| title_full | Gel immersion endoscopic submucosal dissection: clinical experience with 13 cases of superficial esophageal cancer |
| title_fullStr | Gel immersion endoscopic submucosal dissection: clinical experience with 13 cases of superficial esophageal cancer |
| title_full_unstemmed | Gel immersion endoscopic submucosal dissection: clinical experience with 13 cases of superficial esophageal cancer |
| title_short | Gel immersion endoscopic submucosal dissection: clinical experience with 13 cases of superficial esophageal cancer |
| title_sort | gel immersion endoscopic submucosal dissection clinical experience with 13 cases of superficial esophageal cancer |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/a-1894-0719 |
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