Correlation Between Circulating Leptin Level with Left Ventricle Mass in Normotensive Men
Background.Obesity is one of Cardiovascular risk factor. Obesity caused increase in heart mass due to cellular hypertrophic and metaplastic proses, independently of hemodynamic factors such as blood pressure. There were hyperleptinemia in obesity due to the selective Leptin resistency in central ner...
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Indonesian Heart Association
2013-06-01
|
Series: | Majalah Kardiologi Indonesia |
Subjects: | |
Online Access: | http://ijconline.id/index.php/ijc/article/view/220 |
_version_ | 1818155317125447680 |
---|---|
author | Richard Indra Gunawan Adrianus Kosasih Oktavia Lilyasari Andang H Joesoef RWM Kaligis |
author_facet | Richard Indra Gunawan Adrianus Kosasih Oktavia Lilyasari Andang H Joesoef RWM Kaligis |
author_sort | Richard Indra Gunawan |
collection | DOAJ |
description | Background.Obesity is one of Cardiovascular risk factor. Obesity caused increase in heart mass due to cellular hypertrophic and metaplastic proses, independently of hemodynamic factors such as blood pressure. There were hyperleptinemia in obesity due to the selective Leptin resistency in central nervous system and peripheral organs. Study with cultured rat cardiomyocyte have shown hypertrophy and hyperplastic effect of Leptin to cardiomyocyte. Some clinical studies have shown correlation between circulating Leptin level with Left Ventricle Mass in hypertensive and insulin resistance men.
Objective. This study aimed to elaborate the correlation between circu-lating Leptin level with Left Ventricle Mass in normotensive men.
Methods. A cross sectional study was performed with normotensive men, which included 40 obese normotensive and 40 normoweight men. All patients underwent physical and laboratory assessment and examination of Left Ventricle with echocardiography. The circulating Leptin level were determined by ELISA method. The Leptin level were expressed as median (25th percentile; 75th percentile)
Results. The circulating Leptin level were significantly different between the obese normotensive and the lean group. The Left Ventricle Mass in Obese increased, although have not fulfilled the criteria for Left Ventricle Hypertrophy. There were significant correlation between Left Ventricle Mass with BMI (r = 0,711; p<0,001) and waist circumference (r = 0,732; p<0,001). Respectively, there were significant correlation between Left Ventricle Mass Index with BMI (r = 0.541; p<0.001) and waist circumfer-ence (r = 0,558; p<0.001. There were significant correlation between circulating Leptin level with Left Ventricle Mass (r = 0,510; <0,001) and Left Ventricle Mass Index (r = 0,414; p<0,001) in obese men.
Conclusion.Circulating Leptin level is correlated with Left Ventricle Mass in normotensive men. |
first_indexed | 2024-12-11T14:40:29Z |
format | Article |
id | doaj.art-e9fb4ceda6974b0e8236fad133835817 |
institution | Directory Open Access Journal |
issn | 0126-3773 2620-4762 |
language | English |
last_indexed | 2024-12-11T14:40:29Z |
publishDate | 2013-06-01 |
publisher | Indonesian Heart Association |
record_format | Article |
series | Majalah Kardiologi Indonesia |
spelling | doaj.art-e9fb4ceda6974b0e8236fad1338358172022-12-22T01:01:58ZengIndonesian Heart AssociationMajalah Kardiologi Indonesia0126-37732620-47622013-06-0128510.30701/ijc.v28i5.220Correlation Between Circulating Leptin Level with Left Ventricle Mass in Normotensive MenRichard Indra Gunawan0Adrianus Kosasih1Oktavia Lilyasari2Andang H Joesoef3RWM Kaligis4Department of Cardiology and Vascular Medicine, Faculty of Medicine - University of Indonesia National Cardiac Center, Harapan Kita, JakartaDepartment of Cardiology and Vascular Medicine, Faculty of Medicine - University of Indonesia National Cardiac Center, Harapan Kita, JakartaDepartment of Cardiology and Vascular Medicine, Faculty of Medicine - University of Indonesia National Cardiac Center, Harapan Kita, JakartaDepartment of Cardiology and Vascular Medicine, Faculty of Medicine - University of Indonesia National Cardiac Center, Harapan Kita, JakartaDepartment of Cardiology and Vascular Medicine, Faculty of Medicine - University of Indonesia National Cardiac Center, Harapan Kita, JakartaBackground.Obesity is one of Cardiovascular risk factor. Obesity caused increase in heart mass due to cellular hypertrophic and metaplastic proses, independently of hemodynamic factors such as blood pressure. There were hyperleptinemia in obesity due to the selective Leptin resistency in central nervous system and peripheral organs. Study with cultured rat cardiomyocyte have shown hypertrophy and hyperplastic effect of Leptin to cardiomyocyte. Some clinical studies have shown correlation between circulating Leptin level with Left Ventricle Mass in hypertensive and insulin resistance men. Objective. This study aimed to elaborate the correlation between circu-lating Leptin level with Left Ventricle Mass in normotensive men. Methods. A cross sectional study was performed with normotensive men, which included 40 obese normotensive and 40 normoweight men. All patients underwent physical and laboratory assessment and examination of Left Ventricle with echocardiography. The circulating Leptin level were determined by ELISA method. The Leptin level were expressed as median (25th percentile; 75th percentile) Results. The circulating Leptin level were significantly different between the obese normotensive and the lean group. The Left Ventricle Mass in Obese increased, although have not fulfilled the criteria for Left Ventricle Hypertrophy. There were significant correlation between Left Ventricle Mass with BMI (r = 0,711; p<0,001) and waist circumference (r = 0,732; p<0,001). Respectively, there were significant correlation between Left Ventricle Mass Index with BMI (r = 0.541; p<0.001) and waist circumfer-ence (r = 0,558; p<0.001. There were significant correlation between circulating Leptin level with Left Ventricle Mass (r = 0,510; <0,001) and Left Ventricle Mass Index (r = 0,414; p<0,001) in obese men. Conclusion.Circulating Leptin level is correlated with Left Ventricle Mass in normotensive men.http://ijconline.id/index.php/ijc/article/view/220LeptinLeft Ventricle Massnormotensive |
spellingShingle | Richard Indra Gunawan Adrianus Kosasih Oktavia Lilyasari Andang H Joesoef RWM Kaligis Correlation Between Circulating Leptin Level with Left Ventricle Mass in Normotensive Men Majalah Kardiologi Indonesia Leptin Left Ventricle Mass normotensive |
title | Correlation Between Circulating Leptin Level with Left Ventricle Mass in Normotensive Men |
title_full | Correlation Between Circulating Leptin Level with Left Ventricle Mass in Normotensive Men |
title_fullStr | Correlation Between Circulating Leptin Level with Left Ventricle Mass in Normotensive Men |
title_full_unstemmed | Correlation Between Circulating Leptin Level with Left Ventricle Mass in Normotensive Men |
title_short | Correlation Between Circulating Leptin Level with Left Ventricle Mass in Normotensive Men |
title_sort | correlation between circulating leptin level with left ventricle mass in normotensive men |
topic | Leptin Left Ventricle Mass normotensive |
url | http://ijconline.id/index.php/ijc/article/view/220 |
work_keys_str_mv | AT richardindragunawan correlationbetweencirculatingleptinlevelwithleftventriclemassinnormotensivemen AT adrianuskosasih correlationbetweencirculatingleptinlevelwithleftventriclemassinnormotensivemen AT oktavialilyasari correlationbetweencirculatingleptinlevelwithleftventriclemassinnormotensivemen AT andanghjoesoef correlationbetweencirculatingleptinlevelwithleftventriclemassinnormotensivemen AT rwmkaligis correlationbetweencirculatingleptinlevelwithleftventriclemassinnormotensivemen |