Correlation Between Circulating Leptin Level with Left Ventricle Mass in Normotensive Men

Background.Obesity is one of Cardiovascular risk factor. Obesity caused increase in heart mass due to cellular hypertrophic and metaplastic proses, independently of hemodynamic factors such as blood pressure. There were hyperleptinemia in obesity due to the selective Leptin resistency in central ner...

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Main Authors: Richard Indra Gunawan, Adrianus Kosasih, Oktavia Lilyasari, Andang H Joesoef, RWM Kaligis
Format: Article
Language:English
Published: Indonesian Heart Association 2013-06-01
Series:Majalah Kardiologi Indonesia
Subjects:
Online Access:http://ijconline.id/index.php/ijc/article/view/220
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author Richard Indra Gunawan
Adrianus Kosasih
Oktavia Lilyasari
Andang H Joesoef
RWM Kaligis
author_facet Richard Indra Gunawan
Adrianus Kosasih
Oktavia Lilyasari
Andang H Joesoef
RWM Kaligis
author_sort Richard Indra Gunawan
collection DOAJ
description Background.Obesity is one of Cardiovascular risk factor. Obesity caused increase in heart mass due to cellular hypertrophic and metaplastic proses, independently of hemodynamic factors such as blood pressure. There were hyperleptinemia in obesity due to the selective Leptin resistency in central nervous system and peripheral organs. Study with cultured rat cardiomyocyte have shown hypertrophy and hyperplastic effect of Leptin to cardiomyocyte. Some clinical studies have shown correlation between circulating Leptin level with Left Ventricle Mass in hypertensive and insulin resistance men. Objective. This study aimed to elaborate the correlation between circu-lating Leptin level with Left Ventricle Mass in normotensive men. Methods. A cross sectional study was performed with normotensive men, which included 40 obese normotensive and 40 normoweight men. All patients underwent physical and laboratory assessment and examination of Left Ventricle with echocardiography. The circulating Leptin level were determined by ELISA method. The Leptin level were expressed as median (25th percentile; 75th percentile) Results. The circulating Leptin level were significantly different between the obese normotensive and the lean group. The Left Ventricle Mass in Obese increased, although have not fulfilled the criteria for Left Ventricle Hypertrophy. There were significant correlation between Left Ventricle Mass with BMI (r = 0,711; p<0,001) and waist circumference (r = 0,732; p<0,001). Respectively, there were significant correlation between Left Ventricle Mass Index with BMI (r = 0.541; p<0.001) and waist circumfer-ence (r = 0,558; p<0.001. There were significant correlation between circulating Leptin level with Left Ventricle Mass (r = 0,510; <0,001) and Left Ventricle Mass Index (r = 0,414; p<0,001) in obese men. Conclusion.Circulating Leptin level is correlated with Left Ventricle Mass in normotensive men.
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spelling doaj.art-e9fb4ceda6974b0e8236fad1338358172022-12-22T01:01:58ZengIndonesian Heart AssociationMajalah Kardiologi Indonesia0126-37732620-47622013-06-0128510.30701/ijc.v28i5.220Correlation Between Circulating Leptin Level with Left Ventricle Mass in Normotensive MenRichard Indra Gunawan0Adrianus Kosasih1Oktavia Lilyasari2Andang H Joesoef3RWM Kaligis4Department of Cardiology and Vascular Medicine, Faculty of Medicine - University of Indonesia National Cardiac Center, Harapan Kita, JakartaDepartment of Cardiology and Vascular Medicine, Faculty of Medicine - University of Indonesia National Cardiac Center, Harapan Kita, JakartaDepartment of Cardiology and Vascular Medicine, Faculty of Medicine - University of Indonesia National Cardiac Center, Harapan Kita, JakartaDepartment of Cardiology and Vascular Medicine, Faculty of Medicine - University of Indonesia National Cardiac Center, Harapan Kita, JakartaDepartment of Cardiology and Vascular Medicine, Faculty of Medicine - University of Indonesia National Cardiac Center, Harapan Kita, JakartaBackground.Obesity is one of Cardiovascular risk factor. Obesity caused increase in heart mass due to cellular hypertrophic and metaplastic proses, independently of hemodynamic factors such as blood pressure. There were hyperleptinemia in obesity due to the selective Leptin resistency in central nervous system and peripheral organs. Study with cultured rat cardiomyocyte have shown hypertrophy and hyperplastic effect of Leptin to cardiomyocyte. Some clinical studies have shown correlation between circulating Leptin level with Left Ventricle Mass in hypertensive and insulin resistance men. Objective. This study aimed to elaborate the correlation between circu-lating Leptin level with Left Ventricle Mass in normotensive men. Methods. A cross sectional study was performed with normotensive men, which included 40 obese normotensive and 40 normoweight men. All patients underwent physical and laboratory assessment and examination of Left Ventricle with echocardiography. The circulating Leptin level were determined by ELISA method. The Leptin level were expressed as median (25th percentile; 75th percentile) Results. The circulating Leptin level were significantly different between the obese normotensive and the lean group. The Left Ventricle Mass in Obese increased, although have not fulfilled the criteria for Left Ventricle Hypertrophy. There were significant correlation between Left Ventricle Mass with BMI (r = 0,711; p<0,001) and waist circumference (r = 0,732; p<0,001). Respectively, there were significant correlation between Left Ventricle Mass Index with BMI (r = 0.541; p<0.001) and waist circumfer-ence (r = 0,558; p<0.001. There were significant correlation between circulating Leptin level with Left Ventricle Mass (r = 0,510; <0,001) and Left Ventricle Mass Index (r = 0,414; p<0,001) in obese men. Conclusion.Circulating Leptin level is correlated with Left Ventricle Mass in normotensive men.http://ijconline.id/index.php/ijc/article/view/220LeptinLeft Ventricle Massnormotensive
spellingShingle Richard Indra Gunawan
Adrianus Kosasih
Oktavia Lilyasari
Andang H Joesoef
RWM Kaligis
Correlation Between Circulating Leptin Level with Left Ventricle Mass in Normotensive Men
Majalah Kardiologi Indonesia
Leptin
Left Ventricle Mass
normotensive
title Correlation Between Circulating Leptin Level with Left Ventricle Mass in Normotensive Men
title_full Correlation Between Circulating Leptin Level with Left Ventricle Mass in Normotensive Men
title_fullStr Correlation Between Circulating Leptin Level with Left Ventricle Mass in Normotensive Men
title_full_unstemmed Correlation Between Circulating Leptin Level with Left Ventricle Mass in Normotensive Men
title_short Correlation Between Circulating Leptin Level with Left Ventricle Mass in Normotensive Men
title_sort correlation between circulating leptin level with left ventricle mass in normotensive men
topic Leptin
Left Ventricle Mass
normotensive
url http://ijconline.id/index.php/ijc/article/view/220
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