Electrospun Silk Fibroin/Polylactic-co-glycolic Acid/Black Phosphorus Nanosheets Nanofibrous Membrane with Photothermal Therapy Potential for Cancer
Photothermal therapy is a promising treating method for cancers since it is safe and easily controllable. Black phosphorus (BP) nanosheets have drawn tremendous attention as a novel biodegradable thermotherapy material, owing to their excellent biocompatibility and photothermal properties. In this s...
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MDPI AG
2022-07-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/14/4563 |
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| author | Xia Li Jiale Zhou Haiyan Wu Fangyin Dai Jiashen Li Zhi Li |
| author_facet | Xia Li Jiale Zhou Haiyan Wu Fangyin Dai Jiashen Li Zhi Li |
| author_sort | Xia Li |
| collection | DOAJ |
| description | Photothermal therapy is a promising treating method for cancers since it is safe and easily controllable. Black phosphorus (BP) nanosheets have drawn tremendous attention as a novel biodegradable thermotherapy material, owing to their excellent biocompatibility and photothermal properties. In this study, silk fibroin (SF) was used to exfoliate BP with long-term stability and good solution-processability. Then, the prepared BP@SF was introduced into fibrous membranes by electrospinning, together with SF and polylactic-co-glycolic acid (PLGA). The SF/PLGA/BP@SF membranes had relatively smooth and even fibers and the maximum stress was 2.92 MPa. Most importantly, the SF/PLGA/BP@SF membranes exhibited excellent photothermal properties, which could be controlled by the BP@SF content and near infrared (NIR) light power. The temperature of SF/PLGA/BP@SF composite membrane was increased by 15.26 °C under NIR (808 nm, 2.5 W/cm<sup>2</sup>) irradiation for 10 min. The photothermal property of SF/PLGA/BP@SF membranes significantly killed the HepG2 cancer cells in vitro, indicating its good potential for application in local treatment of cancer. |
| first_indexed | 2024-03-09T06:07:46Z |
| format | Article |
| id | doaj.art-e9fbcd4b37004e3eb3ac305da2eea9b6 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T06:07:46Z |
| publishDate | 2022-07-01 |
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| series | Molecules |
| spelling | doaj.art-e9fbcd4b37004e3eb3ac305da2eea9b62023-12-03T12:02:04ZengMDPI AGMolecules1420-30492022-07-012714456310.3390/molecules27144563Electrospun Silk Fibroin/Polylactic-co-glycolic Acid/Black Phosphorus Nanosheets Nanofibrous Membrane with Photothermal Therapy Potential for CancerXia Li0Jiale Zhou1Haiyan Wu2Fangyin Dai3Jiashen Li4Zhi Li5State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing 400715, ChinaState Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing 400715, ChinaState Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing 400715, ChinaState Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing 400715, ChinaDepartment of Materials, The University of Manchester, Manchester M13 9PL, UKState Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing 400715, ChinaPhotothermal therapy is a promising treating method for cancers since it is safe and easily controllable. Black phosphorus (BP) nanosheets have drawn tremendous attention as a novel biodegradable thermotherapy material, owing to their excellent biocompatibility and photothermal properties. In this study, silk fibroin (SF) was used to exfoliate BP with long-term stability and good solution-processability. Then, the prepared BP@SF was introduced into fibrous membranes by electrospinning, together with SF and polylactic-co-glycolic acid (PLGA). The SF/PLGA/BP@SF membranes had relatively smooth and even fibers and the maximum stress was 2.92 MPa. Most importantly, the SF/PLGA/BP@SF membranes exhibited excellent photothermal properties, which could be controlled by the BP@SF content and near infrared (NIR) light power. The temperature of SF/PLGA/BP@SF composite membrane was increased by 15.26 °C under NIR (808 nm, 2.5 W/cm<sup>2</sup>) irradiation for 10 min. The photothermal property of SF/PLGA/BP@SF membranes significantly killed the HepG2 cancer cells in vitro, indicating its good potential for application in local treatment of cancer.https://www.mdpi.com/1420-3049/27/14/4563black phosphorus nanosheetssilk fibroincancerphotothermal therapyelectrospinning |
| spellingShingle | Xia Li Jiale Zhou Haiyan Wu Fangyin Dai Jiashen Li Zhi Li Electrospun Silk Fibroin/Polylactic-co-glycolic Acid/Black Phosphorus Nanosheets Nanofibrous Membrane with Photothermal Therapy Potential for Cancer Molecules black phosphorus nanosheets silk fibroin cancer photothermal therapy electrospinning |
| title | Electrospun Silk Fibroin/Polylactic-co-glycolic Acid/Black Phosphorus Nanosheets Nanofibrous Membrane with Photothermal Therapy Potential for Cancer |
| title_full | Electrospun Silk Fibroin/Polylactic-co-glycolic Acid/Black Phosphorus Nanosheets Nanofibrous Membrane with Photothermal Therapy Potential for Cancer |
| title_fullStr | Electrospun Silk Fibroin/Polylactic-co-glycolic Acid/Black Phosphorus Nanosheets Nanofibrous Membrane with Photothermal Therapy Potential for Cancer |
| title_full_unstemmed | Electrospun Silk Fibroin/Polylactic-co-glycolic Acid/Black Phosphorus Nanosheets Nanofibrous Membrane with Photothermal Therapy Potential for Cancer |
| title_short | Electrospun Silk Fibroin/Polylactic-co-glycolic Acid/Black Phosphorus Nanosheets Nanofibrous Membrane with Photothermal Therapy Potential for Cancer |
| title_sort | electrospun silk fibroin polylactic co glycolic acid black phosphorus nanosheets nanofibrous membrane with photothermal therapy potential for cancer |
| topic | black phosphorus nanosheets silk fibroin cancer photothermal therapy electrospinning |
| url | https://www.mdpi.com/1420-3049/27/14/4563 |
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