Combining Metabolomics and Interpretable Machine Learning to Reveal Plasma Metabolic Profiling and Biological Correlates of Alcohol-Dependent Inpatients: What About Tryptophan Metabolism Regulation?

Combining Metabolomics and Interpretable Machine Learning to Reveal Plasma Metabolic Profiling and Biological Correlates of Alcohol-Dependent Inpatients: What About Tryptophan Metabolism Regulation?

Alcohol dependence (AD) is a condition of alcohol use disorder in which the drinkers frequently develop emotional symptoms associated with a continuous alcohol intake. AD characterized by metabolic disturbances can be quantitatively analyzed by metabolomics to identify the alterations in metabolic p...

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Bibliographic Details
Main Authors: Xiuqing Zhu, Jiaxin Huang, Shanqing Huang, Yuguan Wen, Xiaochang Lan, Xipei Wang, Chuanli Lu, Zhanzhang Wang, Ni Fan, Dewei Shang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Molecular Biosciences
Subjects:
alcohol dependence
metabolic profiling
biological correlate
metabolomics
machine learning
tryptophan metabolism
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2021.760669/full

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