Mitophagy in atherosclerosis: from mechanism to therapy
Mitophagy is a type of autophagy that can selectively eliminate damaged and depolarized mitochondria to maintain mitochondrial activity and cellular homeostasis. Several pathways have been found to participate in different steps of mitophagy. Mitophagy plays a significant role in the homeostasis and...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-05-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1165507/full |
| _version_ | 1827946604257083392 |
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| author | Yanhong Zhang Jiajun Weng Jiajun Weng Jiajun Weng Luyao Huan Luyao Huan Song Sheng Fengqin Xu Fengqin Xu Fengqin Xu |
| author_facet | Yanhong Zhang Jiajun Weng Jiajun Weng Jiajun Weng Luyao Huan Luyao Huan Song Sheng Fengqin Xu Fengqin Xu Fengqin Xu |
| author_sort | Yanhong Zhang |
| collection | DOAJ |
| description | Mitophagy is a type of autophagy that can selectively eliminate damaged and depolarized mitochondria to maintain mitochondrial activity and cellular homeostasis. Several pathways have been found to participate in different steps of mitophagy. Mitophagy plays a significant role in the homeostasis and physiological function of vascular endothelial cells, vascular smooth muscle cells, and macrophages, and is involved in the development of atherosclerosis (AS). At present, many medications and natural chemicals have been shown to alter mitophagy and slow the progression of AS. This review serves as an introduction to the field of mitophagy for researchers interested in targeting this pathway as part of a potential AS management strategy. |
| first_indexed | 2024-03-13T11:03:57Z |
| format | Article |
| id | doaj.art-e9fd061ca30f4891ba7a8421b93a78c6 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-13T11:03:57Z |
| publishDate | 2023-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-e9fd061ca30f4891ba7a8421b93a78c62023-05-16T15:03:01ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-05-011410.3389/fimmu.2023.11655071165507Mitophagy in atherosclerosis: from mechanism to therapyYanhong Zhang0Jiajun Weng1Jiajun Weng2Jiajun Weng3Luyao Huan4Luyao Huan5Song Sheng6Fengqin Xu7Fengqin Xu8Fengqin Xu9Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaXiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaTraditional Chinese Medicine Clinical Medical School (Xiyuan), Peking University, Beijing, ChinaDepartment of Integrated Traditional and Western Medicine, Peking University Health Science Center, Beijing, ChinaXiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaGraduate School of Beijing University of Chinese Medicine, Beijing, ChinaXiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaXiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaTraditional Chinese Medicine Clinical Medical School (Xiyuan), Peking University, Beijing, ChinaDepartment of Integrated Traditional and Western Medicine, Peking University Health Science Center, Beijing, ChinaMitophagy is a type of autophagy that can selectively eliminate damaged and depolarized mitochondria to maintain mitochondrial activity and cellular homeostasis. Several pathways have been found to participate in different steps of mitophagy. Mitophagy plays a significant role in the homeostasis and physiological function of vascular endothelial cells, vascular smooth muscle cells, and macrophages, and is involved in the development of atherosclerosis (AS). At present, many medications and natural chemicals have been shown to alter mitophagy and slow the progression of AS. This review serves as an introduction to the field of mitophagy for researchers interested in targeting this pathway as part of a potential AS management strategy.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1165507/fullatherosclerosismitophagydifferent cell typesmechanism progressiondrug and natural product progression |
| spellingShingle | Yanhong Zhang Jiajun Weng Jiajun Weng Jiajun Weng Luyao Huan Luyao Huan Song Sheng Fengqin Xu Fengqin Xu Fengqin Xu Mitophagy in atherosclerosis: from mechanism to therapy Frontiers in Immunology atherosclerosis mitophagy different cell types mechanism progression drug and natural product progression |
| title | Mitophagy in atherosclerosis: from mechanism to therapy |
| title_full | Mitophagy in atherosclerosis: from mechanism to therapy |
| title_fullStr | Mitophagy in atherosclerosis: from mechanism to therapy |
| title_full_unstemmed | Mitophagy in atherosclerosis: from mechanism to therapy |
| title_short | Mitophagy in atherosclerosis: from mechanism to therapy |
| title_sort | mitophagy in atherosclerosis from mechanism to therapy |
| topic | atherosclerosis mitophagy different cell types mechanism progression drug and natural product progression |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1165507/full |
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