Tanshinone IIA Stimulates Cystathionine γ-Lyase Expression and Protects Endothelial Cells from Oxidative Injury

Tanshinone IIA Stimulates Cystathionine γ-Lyase Expression and Protects Endothelial Cells from Oxidative Injury

Tanshinone IIA (Tan IIA), an active ingredient of Danshen, is a well-used drug to treat cardiovascular diseases. Currently, the mechanisms involved remain poorly understood. Given that many actions of Tan IIA could be similarly achieved by hydrogen sulfide (H<sub>2</sub>S), we speculated...

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Bibliographic Details
Main Authors: Qiaojing Yan, Zhimin Mao, Jingru Hong, Kun Gao, Manabu Niimi, Takahiko Mitsui, Jian Yao
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Antioxidants
Subjects:
tanshinone IIA
cystathionine γ-lyase
oxidative cell injury
hydrogen sulfide
protein kinase A
endothelial cells
Online Access:https://www.mdpi.com/2076-3921/10/7/1007

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