Research progress in the relationship between gut microbia and its metabolites and gestational diabetes mellitus
The global incidence of gestational diabetes mellitus (GDM) continues to rise in recent years. Research has shown that GDM can increase the risk of adverse pregnancy outcomes in pregnant women and lead to malignant intergenerational circulation. The etiology of GDM is complex and the pathogenesis ha...
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| Format: | Article |
| Language: | zho |
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Editorial Office of Journal of Shanghai Jiao Tong University (Medical Science)
2023-05-01
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| Series: | Shanghai Jiaotong Daxue xuebao. Yixue ban |
| Subjects: | |
| Online Access: | https://xuebao.shsmu.edu.cn/article/2023/1674-8115/1674-8115-2023-43-5-641.shtml |
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| author | LIU Qianruo FANG Zichen WU Yuhan ZHONG Xianxin GUO Muhe JIA Jie |
| author_facet | LIU Qianruo FANG Zichen WU Yuhan ZHONG Xianxin GUO Muhe JIA Jie |
| author_sort | LIU Qianruo |
| collection | DOAJ |
| description | The global incidence of gestational diabetes mellitus (GDM) continues to rise in recent years. Research has shown that GDM can increase the risk of adverse pregnancy outcomes in pregnant women and lead to malignant intergenerational circulation. The etiology of GDM is complex and the pathogenesis has not been fully elucidated. Maternal dietary assessment and guidance is the first-line method for managing GDM in clinical practice. Reasonable diet plays an important role in gut microbia and its metabolites during pregnancy, and the dysfunction of gut microbia is closely related to the occurrence of metabolic diseases. It has been shown that gut microbial metabolites such as short-chain fatty acids (SCFAs), trimethylamine oxide (TMAO) and bile acids are strongly influenced by diet and play an important role in metabolic disorders related to insulin resistance (such as GDM). Progress has been made in the prevention and treatment of metabolic diseases by improving gut microbia through medical nutrition therapy, which provides a new direction for the control of GDM. The status quo of GDM, the characteristics and alteration of gut microbia in pregnant women with GDM, the GDM-related gut microbial metabolites, and the feasible prevention and treatment of GDM by targeting gut microbia and its metabolites are reviewed. |
| first_indexed | 2024-03-08T21:52:21Z |
| format | Article |
| id | doaj.art-e9fe1acc17f1484881cbe099e50b6a3f |
| institution | Directory Open Access Journal |
| issn | 1674-8115 |
| language | zho |
| last_indexed | 2024-03-08T21:52:21Z |
| publishDate | 2023-05-01 |
| publisher | Editorial Office of Journal of Shanghai Jiao Tong University (Medical Science) |
| record_format | Article |
| series | Shanghai Jiaotong Daxue xuebao. Yixue ban |
| spelling | doaj.art-e9fe1acc17f1484881cbe099e50b6a3f2023-12-20T06:18:38ZzhoEditorial Office of Journal of Shanghai Jiao Tong University (Medical Science)Shanghai Jiaotong Daxue xuebao. Yixue ban1674-81152023-05-0143564164710.3969/j.issn.1674-8115.2023.05.0161674-8115（2023）05-0641-07Research progress in the relationship between gut microbia and its metabolites and gestational diabetes mellitusLIU Qianruo0FANG Zichen1WU Yuhan2ZHONG Xianxin3GUO Muhe4JIA Jie5Department of Clinical Nutrition, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, ChinaDepartment of Clinical Nutrition, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, ChinaSchool of Pediatrics, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, ChinaCollege of Clinical Medicine, Shanghai Ninth People′s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, ChinaDepartment of Clinical Nutrition, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, ChinaDepartment of Clinical Nutrition, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, ChinaThe global incidence of gestational diabetes mellitus (GDM) continues to rise in recent years. Research has shown that GDM can increase the risk of adverse pregnancy outcomes in pregnant women and lead to malignant intergenerational circulation. The etiology of GDM is complex and the pathogenesis has not been fully elucidated. Maternal dietary assessment and guidance is the first-line method for managing GDM in clinical practice. Reasonable diet plays an important role in gut microbia and its metabolites during pregnancy, and the dysfunction of gut microbia is closely related to the occurrence of metabolic diseases. It has been shown that gut microbial metabolites such as short-chain fatty acids (SCFAs), trimethylamine oxide (TMAO) and bile acids are strongly influenced by diet and play an important role in metabolic disorders related to insulin resistance (such as GDM). Progress has been made in the prevention and treatment of metabolic diseases by improving gut microbia through medical nutrition therapy, which provides a new direction for the control of GDM. The status quo of GDM, the characteristics and alteration of gut microbia in pregnant women with GDM, the GDM-related gut microbial metabolites, and the feasible prevention and treatment of GDM by targeting gut microbia and its metabolites are reviewed.https://xuebao.shsmu.edu.cn/article/2023/1674-8115/1674-8115-2023-43-5-641.shtmlgestational diabetes mellitus (gdm)gut microbiagut microbia metabolitedietary estimation |
| spellingShingle | LIU Qianruo FANG Zichen WU Yuhan ZHONG Xianxin GUO Muhe JIA Jie Research progress in the relationship between gut microbia and its metabolites and gestational diabetes mellitus Shanghai Jiaotong Daxue xuebao. Yixue ban gestational diabetes mellitus (gdm) gut microbia gut microbia metabolite dietary estimation |
| title | Research progress in the relationship between gut microbia and its metabolites and gestational diabetes mellitus |
| title_full | Research progress in the relationship between gut microbia and its metabolites and gestational diabetes mellitus |
| title_fullStr | Research progress in the relationship between gut microbia and its metabolites and gestational diabetes mellitus |
| title_full_unstemmed | Research progress in the relationship between gut microbia and its metabolites and gestational diabetes mellitus |
| title_short | Research progress in the relationship between gut microbia and its metabolites and gestational diabetes mellitus |
| title_sort | research progress in the relationship between gut microbia and its metabolites and gestational diabetes mellitus |
| topic | gestational diabetes mellitus (gdm) gut microbia gut microbia metabolite dietary estimation |
| url | https://xuebao.shsmu.edu.cn/article/2023/1674-8115/1674-8115-2023-43-5-641.shtml |
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