Interactions between m6A modification and miRNAs in malignant tumors
Abstract Recently, the regulatory role of epigenetic modifications in the occurrence and development of malignant tumors has attracted extensive attention. RNA m6A methylation is the most abundant RNA modification in eukaryotic cells and regulates RNA transcription, processing, splicing, degradation...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2021-06-01
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| Series: | Cell Death and Disease |
| Online Access: | https://doi.org/10.1038/s41419-021-03868-5 |
| _version_ | 1819088871502118912 |
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| author | Xiao Han Jing Guo Zhipeng Fan |
| author_facet | Xiao Han Jing Guo Zhipeng Fan |
| author_sort | Xiao Han |
| collection | DOAJ |
| description | Abstract Recently, the regulatory role of epigenetic modifications in the occurrence and development of malignant tumors has attracted extensive attention. RNA m6A methylation is the most abundant RNA modification in eukaryotic cells and regulates RNA transcription, processing, splicing, degradation, and translation. As important biomarkers, miRNAs play a crucial role in the diagnosis and treatment of diseases as well as in the development of anti-tumor drugs. Recently, increasing evidence has shown that m6A modification plays a vital role in regulating miRNA biosynthesis. We, herein, have reviewed the enzyme system involved in m6A methylation and the crosstalk between m6A modification and miRNAs in cancer. In addition, we have discussed the potential clinical applications and possible development directions of this field in the future. |
| first_indexed | 2024-12-21T21:58:55Z |
| format | Article |
| id | doaj.art-e9fed52b6f5248fe864734782d990625 |
| institution | Directory Open Access Journal |
| issn | 2041-4889 |
| language | English |
| last_indexed | 2024-12-21T21:58:55Z |
| publishDate | 2021-06-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Cell Death and Disease |
| spelling | doaj.art-e9fed52b6f5248fe864734782d9906252022-12-21T18:48:53ZengNature Publishing GroupCell Death and Disease2041-48892021-06-0112611010.1038/s41419-021-03868-5Interactions between m6A modification and miRNAs in malignant tumorsXiao Han0Jing Guo1Zhipeng Fan2Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, Beijing Stomatological Hospital, School of Stomatology, Capital Medical UniversitySchool of Stomatology, Nanchang University, The Key Laboratory of Oral BiomedicineBeijing Key Laboratory of Tooth Regeneration and Function Reconstruction, Beijing Stomatological Hospital, School of Stomatology, Capital Medical UniversityAbstract Recently, the regulatory role of epigenetic modifications in the occurrence and development of malignant tumors has attracted extensive attention. RNA m6A methylation is the most abundant RNA modification in eukaryotic cells and regulates RNA transcription, processing, splicing, degradation, and translation. As important biomarkers, miRNAs play a crucial role in the diagnosis and treatment of diseases as well as in the development of anti-tumor drugs. Recently, increasing evidence has shown that m6A modification plays a vital role in regulating miRNA biosynthesis. We, herein, have reviewed the enzyme system involved in m6A methylation and the crosstalk between m6A modification and miRNAs in cancer. In addition, we have discussed the potential clinical applications and possible development directions of this field in the future.https://doi.org/10.1038/s41419-021-03868-5 |
| spellingShingle | Xiao Han Jing Guo Zhipeng Fan Interactions between m6A modification and miRNAs in malignant tumors Cell Death and Disease |
| title | Interactions between m6A modification and miRNAs in malignant tumors |
| title_full | Interactions between m6A modification and miRNAs in malignant tumors |
| title_fullStr | Interactions between m6A modification and miRNAs in malignant tumors |
| title_full_unstemmed | Interactions between m6A modification and miRNAs in malignant tumors |
| title_short | Interactions between m6A modification and miRNAs in malignant tumors |
| title_sort | interactions between m6a modification and mirnas in malignant tumors |
| url | https://doi.org/10.1038/s41419-021-03868-5 |
| work_keys_str_mv | AT xiaohan interactionsbetweenm6amodificationandmirnasinmalignanttumors AT jingguo interactionsbetweenm6amodificationandmirnasinmalignanttumors AT zhipengfan interactionsbetweenm6amodificationandmirnasinmalignanttumors |