Novel genetic polymorphisms identified in the clinical isolates of Mycobacterium tuberculosis PE_PGRS33 gene modulate cytokines expression and promotes survival in macrophages

Novel genetic polymorphisms identified in the clinical isolates of Mycobacterium tuberculosis PE_PGRS33 gene modulate cytokines expression and promotes survival in macrophages

Objective: PE_PGRS33 is a member of multi-gene family restricted to pathogenic Mycobacteria and their functions remain elusive. PE_PGRS33 is highly polymorphic in nature to evade host’s immune response. Therefore, we investigated PE_PGRS33 gene polymorphisms in clinical isolates and functional chara...

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Bibliographic Details
Main Authors:	Rahul Gupta, Manitosh Pandey, Amit Kumar Pandey, Pramod Kumar Tiwari, Rabbind Singh Amrathlal
Format:	Article
Language:	English
Published:	Elsevier 2022-02-01
Series:	Journal of Infection and Public Health
Subjects:	PE_PGRS33 polymorphism Tuberculosis M. smegmatis Macrophage infection Cytokines
Online Access:	http://www.sciencedirect.com/science/article/pii/S1876034122000041

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