Effect of Tranexamic Acid on the Reduction of Blood Loss in Craniosynostosis Surgery: A Systematic Review and Meta-analysis
Background:. Although many published studies have investigated the benefits of tranexamic acid (TXA) in reducing perioperative bleeding, no large meta-analysis has been conducted to demonstrate its overall benefit. Methods:. A systematic review was performed by following the Preferred Reporting Item...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer
2023-06-01
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| Series: | Plastic and Reconstructive Surgery, Global Open |
| Online Access: | http://journals.lww.com/prsgo/fulltext/10.1097/GOX.0000000000005021 |
| _version_ | 1797792053728378880 |
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| author | Abdulaziz Alabdulkarim, MD, FRCSC Abdullah A. Al Qurashi, MBBS Nour B. Odeh Ammar S.A. Hashemi, MD Lana M. Arbili Maab S. AlSwealh Malak N. Shakir Sultan M. Banser Lina A. Sharaf Sarah W. Alkhonizy Nouf Z. AlBattal |
| author_facet | Abdulaziz Alabdulkarim, MD, FRCSC Abdullah A. Al Qurashi, MBBS Nour B. Odeh Ammar S.A. Hashemi, MD Lana M. Arbili Maab S. AlSwealh Malak N. Shakir Sultan M. Banser Lina A. Sharaf Sarah W. Alkhonizy Nouf Z. AlBattal |
| author_sort | Abdulaziz Alabdulkarim, MD, FRCSC |
| collection | DOAJ |
| description | Background:. Although many published studies have investigated the benefits of tranexamic acid (TXA) in reducing perioperative bleeding, no large meta-analysis has been conducted to demonstrate its overall benefit.
Methods:. A systematic review was performed by following the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines. PubMed, Cochrane, Ovid, Embase, Web of Science, ClinicalTraisl.Gov, and Scopus databases were searched for articles reporting the benefit of TXA in reducing perioperative bleeding in craniosynostosis surgery from establishment through October 2022. The results of our meta-analysis were pooled across the studies using a random-effects model, and presented as a weighted mean difference with 95% confidence interval (95% CI).
Results:. The database search yielded 3207 articles, of which 27 studies with a corresponding number of 9696 operations were eligible. The meta-analysis included only 18 studies, accounting for 1564 operations. Of those operations, 882 patients received systemic TXA, whereas 682 patients received placebo (normal saline), no intervention, low dose TXA, or other control substances. This meta-analysis demonstrated a significant beneficial effect of TXA in reducing perioperative bleeding, particularly when compared with other controlled substances, with a weighted mean difference of −3.97 (95% CI = −5.29 to −2.28).
Conclusions:. To our knowledge, this is the largest meta-analysis in the literature investigating the benefit of TXA in reducing perioperative blood loss in craniosynostosis surgery. We encourage implementing TXA-protocol systems in hospitals after the appraisal of the data presented in this study. |
| first_indexed | 2024-03-13T02:27:36Z |
| format | Article |
| id | doaj.art-e9ff550bc3d34101ae388ebe9608eec4 |
| institution | Directory Open Access Journal |
| issn | 2169-7574 |
| language | English |
| last_indexed | 2024-03-13T02:27:36Z |
| publishDate | 2023-06-01 |
| publisher | Wolters Kluwer |
| record_format | Article |
| series | Plastic and Reconstructive Surgery, Global Open |
| spelling | doaj.art-e9ff550bc3d34101ae388ebe9608eec42023-06-30T01:49:20ZengWolters KluwerPlastic and Reconstructive Surgery, Global Open2169-75742023-06-01116e502110.1097/GOX.0000000000005021202306000-00062Effect of Tranexamic Acid on the Reduction of Blood Loss in Craniosynostosis Surgery: A Systematic Review and Meta-analysisAbdulaziz Alabdulkarim, MD, FRCSC0Abdullah A. Al Qurashi, MBBS1Nour B. Odeh2Ammar S.A. Hashemi, MD3Lana M. Arbili4Maab S. AlSwealh5Malak N. Shakir6Sultan M. Banser7Lina A. Sharaf8Sarah W. Alkhonizy9Nouf Z. AlBattal10From * Plastic Surgery, Department of Surgery, College of Medicine, Prince Sattam Bin Abdulaziz University, Al Kharj, Saudi Arabia† College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia§ College of Medicine, Alfaisal University, Riyadh, Saudi Arabia¶ Division of Plastic Surgery, Texas Children’s Hospital, Houston, TX§ College of Medicine, Alfaisal University, Riyadh, Saudi Arabia‖ Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia‖ Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia‖ Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia‖ Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia§ College of Medicine, Alfaisal University, Riyadh, Saudi Arabia** College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.Background:. Although many published studies have investigated the benefits of tranexamic acid (TXA) in reducing perioperative bleeding, no large meta-analysis has been conducted to demonstrate its overall benefit. Methods:. A systematic review was performed by following the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines. PubMed, Cochrane, Ovid, Embase, Web of Science, ClinicalTraisl.Gov, and Scopus databases were searched for articles reporting the benefit of TXA in reducing perioperative bleeding in craniosynostosis surgery from establishment through October 2022. The results of our meta-analysis were pooled across the studies using a random-effects model, and presented as a weighted mean difference with 95% confidence interval (95% CI). Results:. The database search yielded 3207 articles, of which 27 studies with a corresponding number of 9696 operations were eligible. The meta-analysis included only 18 studies, accounting for 1564 operations. Of those operations, 882 patients received systemic TXA, whereas 682 patients received placebo (normal saline), no intervention, low dose TXA, or other control substances. This meta-analysis demonstrated a significant beneficial effect of TXA in reducing perioperative bleeding, particularly when compared with other controlled substances, with a weighted mean difference of −3.97 (95% CI = −5.29 to −2.28). Conclusions:. To our knowledge, this is the largest meta-analysis in the literature investigating the benefit of TXA in reducing perioperative blood loss in craniosynostosis surgery. We encourage implementing TXA-protocol systems in hospitals after the appraisal of the data presented in this study.http://journals.lww.com/prsgo/fulltext/10.1097/GOX.0000000000005021 |
| spellingShingle | Abdulaziz Alabdulkarim, MD, FRCSC Abdullah A. Al Qurashi, MBBS Nour B. Odeh Ammar S.A. Hashemi, MD Lana M. Arbili Maab S. AlSwealh Malak N. Shakir Sultan M. Banser Lina A. Sharaf Sarah W. Alkhonizy Nouf Z. AlBattal Effect of Tranexamic Acid on the Reduction of Blood Loss in Craniosynostosis Surgery: A Systematic Review and Meta-analysis Plastic and Reconstructive Surgery, Global Open |
| title | Effect of Tranexamic Acid on the Reduction of Blood Loss in Craniosynostosis Surgery: A Systematic Review and Meta-analysis |
| title_full | Effect of Tranexamic Acid on the Reduction of Blood Loss in Craniosynostosis Surgery: A Systematic Review and Meta-analysis |
| title_fullStr | Effect of Tranexamic Acid on the Reduction of Blood Loss in Craniosynostosis Surgery: A Systematic Review and Meta-analysis |
| title_full_unstemmed | Effect of Tranexamic Acid on the Reduction of Blood Loss in Craniosynostosis Surgery: A Systematic Review and Meta-analysis |
| title_short | Effect of Tranexamic Acid on the Reduction of Blood Loss in Craniosynostosis Surgery: A Systematic Review and Meta-analysis |
| title_sort | effect of tranexamic acid on the reduction of blood loss in craniosynostosis surgery a systematic review and meta analysis |
| url | http://journals.lww.com/prsgo/fulltext/10.1097/GOX.0000000000005021 |
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