Systemic inflammatory response index as an independent predictor of severity in patients with obstructive sleep apnea
Abstract Background Chronic inflammation plays a crucial role in developing various cardiovascular and metabolic disorders. Obstructive sleep apnea (OSA) is a unique condition characterized by the coexistence of cardiovascular and metabolic disturbances, where chronic inflammation may exacerbate dis...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2024-01-01
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| Series: | The Egyptian Journal of Bronchology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s43168-023-00253-y |
| _version_ | 1797363624061173760 |
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| author | Seham Ezzat Fathy Elfeky Asmaa Ali Eman M. Moazen Mohammad Hamad Alhassoon Nesma A. Elzanaty Nouf Mubarak Alazmi Liang Wu Mai M. Saleh |
| author_facet | Seham Ezzat Fathy Elfeky Asmaa Ali Eman M. Moazen Mohammad Hamad Alhassoon Nesma A. Elzanaty Nouf Mubarak Alazmi Liang Wu Mai M. Saleh |
| author_sort | Seham Ezzat Fathy Elfeky |
| collection | DOAJ |
| description | Abstract Background Chronic inflammation plays a crucial role in developing various cardiovascular and metabolic disorders. Obstructive sleep apnea (OSA) is a unique condition characterized by the coexistence of cardiovascular and metabolic disturbances, where chronic inflammation may exacerbate disease progression and severity. This study investigated how different hematological inflammatory cells and mediators can serve as predictive indicators of severe OSA. Methods In a retrospective cohort study, 150 patients suspected of having obstructive sleep apnea (OSA) underwent polysomnography (PSG) to confirm the diagnosis. Based on their apnea-hypopnea index (AHI), the patients were categorized into three groups: mild, moderate, and severe OSA. Blood samples were collected for the assessment of inflammatory blood cells and mediators at the time of diagnosis. Results Among the 150 patients studied, 90 were diagnosed with OSA, and 43 had severe OSA, representing a prevalence rate of 47.7%. Patients with severe OSA were notably older and more likely to have diabetes mellitus and hypertension. After adjusting for age and sex, each one-unit increase in Systemic Inflammatory Response Index (SIRI), C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR) levels was associated with a doubling in the likelihood of having moderate and severe OSA (p < 0.05 for all). However, hypertension was linked to a 16-fold increase in the likelihood of moderate and severe OSA (p = 0.01). Conclusion Our research indicates that comorbidity and inflammatory cells and markers (SIRI, CRP, and ESR) are significantly related to the severity of OSA. |
| first_indexed | 2024-03-08T16:22:50Z |
| format | Article |
| id | doaj.art-ea0068524ed742a7b33d6782d5530be0 |
| institution | Directory Open Access Journal |
| issn | 2314-8551 |
| language | English |
| last_indexed | 2024-03-08T16:22:50Z |
| publishDate | 2024-01-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Journal of Bronchology |
| spelling | doaj.art-ea0068524ed742a7b33d6782d5530be02024-01-07T12:14:54ZengSpringerOpenThe Egyptian Journal of Bronchology2314-85512024-01-0118111010.1186/s43168-023-00253-ySystemic inflammatory response index as an independent predictor of severity in patients with obstructive sleep apneaSeham Ezzat Fathy Elfeky0Asmaa Ali1Eman M. Moazen2Mohammad Hamad Alhassoon3Nesma A. Elzanaty4Nouf Mubarak Alazmi5Liang Wu6Mai M. Saleh7Department of Chest Disease, Faculty of Medicine, Tanta UniversityDepartment of Laboratory Medicine, School of Medicine, Jiangsu UniversityDepartment of Chest Disease, Faculty of Medicine, Al-Azhar UniversityDepartment of Pulmonary Medicine, King Fahad Specialist HospitalDepartment of Medical Physiology, Faculty of Medicine, Tanta UniversityNursing Department, King Fahad Specialist HospitalDepartment of Laboratory Medicine, School of Medicine, Jiangsu UniversityDepartment of Chest Disease, Faculty of Medicine, Tanta UniversityAbstract Background Chronic inflammation plays a crucial role in developing various cardiovascular and metabolic disorders. Obstructive sleep apnea (OSA) is a unique condition characterized by the coexistence of cardiovascular and metabolic disturbances, where chronic inflammation may exacerbate disease progression and severity. This study investigated how different hematological inflammatory cells and mediators can serve as predictive indicators of severe OSA. Methods In a retrospective cohort study, 150 patients suspected of having obstructive sleep apnea (OSA) underwent polysomnography (PSG) to confirm the diagnosis. Based on their apnea-hypopnea index (AHI), the patients were categorized into three groups: mild, moderate, and severe OSA. Blood samples were collected for the assessment of inflammatory blood cells and mediators at the time of diagnosis. Results Among the 150 patients studied, 90 were diagnosed with OSA, and 43 had severe OSA, representing a prevalence rate of 47.7%. Patients with severe OSA were notably older and more likely to have diabetes mellitus and hypertension. After adjusting for age and sex, each one-unit increase in Systemic Inflammatory Response Index (SIRI), C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR) levels was associated with a doubling in the likelihood of having moderate and severe OSA (p < 0.05 for all). However, hypertension was linked to a 16-fold increase in the likelihood of moderate and severe OSA (p = 0.01). Conclusion Our research indicates that comorbidity and inflammatory cells and markers (SIRI, CRP, and ESR) are significantly related to the severity of OSA.https://doi.org/10.1186/s43168-023-00253-yApnea hypopnea index (AHI)Obstructive sleep apnea (OSA)Systemic Inflammatory Response Index (SIRI)Hypertension (HTN) |
| spellingShingle | Seham Ezzat Fathy Elfeky Asmaa Ali Eman M. Moazen Mohammad Hamad Alhassoon Nesma A. Elzanaty Nouf Mubarak Alazmi Liang Wu Mai M. Saleh Systemic inflammatory response index as an independent predictor of severity in patients with obstructive sleep apnea The Egyptian Journal of Bronchology Apnea hypopnea index (AHI) Obstructive sleep apnea (OSA) Systemic Inflammatory Response Index (SIRI) Hypertension (HTN) |
| title | Systemic inflammatory response index as an independent predictor of severity in patients with obstructive sleep apnea |
| title_full | Systemic inflammatory response index as an independent predictor of severity in patients with obstructive sleep apnea |
| title_fullStr | Systemic inflammatory response index as an independent predictor of severity in patients with obstructive sleep apnea |
| title_full_unstemmed | Systemic inflammatory response index as an independent predictor of severity in patients with obstructive sleep apnea |
| title_short | Systemic inflammatory response index as an independent predictor of severity in patients with obstructive sleep apnea |
| title_sort | systemic inflammatory response index as an independent predictor of severity in patients with obstructive sleep apnea |
| topic | Apnea hypopnea index (AHI) Obstructive sleep apnea (OSA) Systemic Inflammatory Response Index (SIRI) Hypertension (HTN) |
| url | https://doi.org/10.1186/s43168-023-00253-y |
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