Streptococcus pneumoniae endophthalmitis: clinical settings, antibiotic susceptibility, and visual outcomes
Abstract Streptococcus pneumoniae endophthalmitis is clinically more severe, more difficult to treat, and carry a higher risk of vision loss, evisceration, or enucleation. This study is to investigate the clinical settings, antibiotic susceptibility, and visual outcomes of S. pneumoniae endophthalmi...
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| Format: | Article |
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Nature Portfolio
2021-03-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-85456-3 |
| _version_ | 1818400557186940928 |
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| author | Kuan-Jen Chen Ying-Jiun Chong Ming-Hui Sun Hung-Chi Chen Laura Liu Yen-Po Chen Wei-Chi Wu Eugene Yu-Chuan Kang Chi-Chun Lai |
| author_facet | Kuan-Jen Chen Ying-Jiun Chong Ming-Hui Sun Hung-Chi Chen Laura Liu Yen-Po Chen Wei-Chi Wu Eugene Yu-Chuan Kang Chi-Chun Lai |
| author_sort | Kuan-Jen Chen |
| collection | DOAJ |
| description | Abstract Streptococcus pneumoniae endophthalmitis is clinically more severe, more difficult to treat, and carry a higher risk of vision loss, evisceration, or enucleation. This study is to investigate the clinical settings, antibiotic susceptibility, and visual outcomes of S. pneumoniae endophthalmitis at a tertiary referral center in Taiwan. S. pneumoniae endophthalmitis was diagnosed in 38 eyes of 38 patients. The main clinical features were postcataract endophthalmitis (n = 13, 34%) and endophthalmitis associated with corneal ulcer (n = 12, 32%), trauma (n = 6, 16%), endogenous etiology (n = 4, 11%), trabeculectomy (n = 2, 5%), and pterygium excision-related scleral ulcer (n = 1, 3%). Presenting visual acuity ranged from counting fingers to no light perception. Pars plana vitrectomy with intravitreal antibiotics was performed in 17 eyes (39%) in primary or secondary treatments. S. pneumoniae isolates were susceptible to vancomycin (38/38, 100%), penicillin (37/38, 97%), ceftriaxone (37/38, 97%), cefuroxime (12/15, 80%), levofloxacin (13/15 ,87%), and moxifloxacin (15/17, 88%). Final visual acuity was better than 20/400 in 3 of 38 eyes (8%), 5/200 to hand motions in 3 eyes (8%), and light perception to no light perception in 32 eyes (84%). Ten eyes (26%) underwent evisceration or enucleation. Although S. pneumoniae isolates were susceptible to vancomycin, S. pneumoniae endophthalmitis had a very poor visual prognosis. |
| first_indexed | 2024-12-14T07:38:28Z |
| format | Article |
| id | doaj.art-ea00e840fa674936ab484739558b24e1 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-14T07:38:28Z |
| publishDate | 2021-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-ea00e840fa674936ab484739558b24e12022-12-21T23:11:07ZengNature PortfolioScientific Reports2045-23222021-03-011111710.1038/s41598-021-85456-3Streptococcus pneumoniae endophthalmitis: clinical settings, antibiotic susceptibility, and visual outcomesKuan-Jen Chen0Ying-Jiun Chong1Ming-Hui Sun2Hung-Chi Chen3Laura Liu4Yen-Po Chen5Wei-Chi Wu6Eugene Yu-Chuan Kang7Chi-Chun Lai8Department of Ophthalmology, Chang Gung Memorial HospitalDepartment of Ophthalmology, Chang Gung Memorial HospitalDepartment of Ophthalmology, Chang Gung Memorial HospitalDepartment of Ophthalmology, Chang Gung Memorial HospitalDepartment of Ophthalmology, Chang Gung Memorial HospitalDepartment of Ophthalmology, Chang Gung Memorial HospitalDepartment of Ophthalmology, Chang Gung Memorial HospitalDepartment of Ophthalmology, Chang Gung Memorial HospitalDepartment of Ophthalmology, Chang Gung Memorial HospitalAbstract Streptococcus pneumoniae endophthalmitis is clinically more severe, more difficult to treat, and carry a higher risk of vision loss, evisceration, or enucleation. This study is to investigate the clinical settings, antibiotic susceptibility, and visual outcomes of S. pneumoniae endophthalmitis at a tertiary referral center in Taiwan. S. pneumoniae endophthalmitis was diagnosed in 38 eyes of 38 patients. The main clinical features were postcataract endophthalmitis (n = 13, 34%) and endophthalmitis associated with corneal ulcer (n = 12, 32%), trauma (n = 6, 16%), endogenous etiology (n = 4, 11%), trabeculectomy (n = 2, 5%), and pterygium excision-related scleral ulcer (n = 1, 3%). Presenting visual acuity ranged from counting fingers to no light perception. Pars plana vitrectomy with intravitreal antibiotics was performed in 17 eyes (39%) in primary or secondary treatments. S. pneumoniae isolates were susceptible to vancomycin (38/38, 100%), penicillin (37/38, 97%), ceftriaxone (37/38, 97%), cefuroxime (12/15, 80%), levofloxacin (13/15 ,87%), and moxifloxacin (15/17, 88%). Final visual acuity was better than 20/400 in 3 of 38 eyes (8%), 5/200 to hand motions in 3 eyes (8%), and light perception to no light perception in 32 eyes (84%). Ten eyes (26%) underwent evisceration or enucleation. Although S. pneumoniae isolates were susceptible to vancomycin, S. pneumoniae endophthalmitis had a very poor visual prognosis.https://doi.org/10.1038/s41598-021-85456-3 |
| spellingShingle | Kuan-Jen Chen Ying-Jiun Chong Ming-Hui Sun Hung-Chi Chen Laura Liu Yen-Po Chen Wei-Chi Wu Eugene Yu-Chuan Kang Chi-Chun Lai Streptococcus pneumoniae endophthalmitis: clinical settings, antibiotic susceptibility, and visual outcomes Scientific Reports |
| title | Streptococcus pneumoniae endophthalmitis: clinical settings, antibiotic susceptibility, and visual outcomes |
| title_full | Streptococcus pneumoniae endophthalmitis: clinical settings, antibiotic susceptibility, and visual outcomes |
| title_fullStr | Streptococcus pneumoniae endophthalmitis: clinical settings, antibiotic susceptibility, and visual outcomes |
| title_full_unstemmed | Streptococcus pneumoniae endophthalmitis: clinical settings, antibiotic susceptibility, and visual outcomes |
| title_short | Streptococcus pneumoniae endophthalmitis: clinical settings, antibiotic susceptibility, and visual outcomes |
| title_sort | streptococcus pneumoniae endophthalmitis clinical settings antibiotic susceptibility and visual outcomes |
| url | https://doi.org/10.1038/s41598-021-85456-3 |
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