Melanopsin mediates retrograde visual signaling in the retina.
The canonical flow of visual signals proceeds from outer to inner retina (photoreceptors → bipolar cells → ganglion cells). However, melanopsin-expressing ganglion cells are photosensitive and functional sustained light signaling to retinal dopaminergic interneurons persists in the absence of rods a...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2012-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3411794?pdf=render |
| _version_ | 1819071518181687296 |
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| author | Dao-Qi Zhang Michael A Belenky Patricia J Sollars Gary E Pickard Douglas G McMahon |
| author_facet | Dao-Qi Zhang Michael A Belenky Patricia J Sollars Gary E Pickard Douglas G McMahon |
| author_sort | Dao-Qi Zhang |
| collection | DOAJ |
| description | The canonical flow of visual signals proceeds from outer to inner retina (photoreceptors → bipolar cells → ganglion cells). However, melanopsin-expressing ganglion cells are photosensitive and functional sustained light signaling to retinal dopaminergic interneurons persists in the absence of rods and cones. Here we show that the sustained-type light response of retinal dopamine neurons requires melanopsin and that the response is mediated by AMPA-type glutamate receptors, defining a retrograde retinal visual signaling pathway that fully reverses the usual flow of light signals in retinal circuits. |
| first_indexed | 2024-12-21T17:23:06Z |
| format | Article |
| id | doaj.art-ea01131631c04da89314390388ec522b |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-21T17:23:06Z |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-ea01131631c04da89314390388ec522b2022-12-21T18:56:07ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-0178e4264710.1371/journal.pone.0042647Melanopsin mediates retrograde visual signaling in the retina.Dao-Qi ZhangMichael A BelenkyPatricia J SollarsGary E PickardDouglas G McMahonThe canonical flow of visual signals proceeds from outer to inner retina (photoreceptors → bipolar cells → ganglion cells). However, melanopsin-expressing ganglion cells are photosensitive and functional sustained light signaling to retinal dopaminergic interneurons persists in the absence of rods and cones. Here we show that the sustained-type light response of retinal dopamine neurons requires melanopsin and that the response is mediated by AMPA-type glutamate receptors, defining a retrograde retinal visual signaling pathway that fully reverses the usual flow of light signals in retinal circuits.http://europepmc.org/articles/PMC3411794?pdf=render |
| spellingShingle | Dao-Qi Zhang Michael A Belenky Patricia J Sollars Gary E Pickard Douglas G McMahon Melanopsin mediates retrograde visual signaling in the retina. PLoS ONE |
| title | Melanopsin mediates retrograde visual signaling in the retina. |
| title_full | Melanopsin mediates retrograde visual signaling in the retina. |
| title_fullStr | Melanopsin mediates retrograde visual signaling in the retina. |
| title_full_unstemmed | Melanopsin mediates retrograde visual signaling in the retina. |
| title_short | Melanopsin mediates retrograde visual signaling in the retina. |
| title_sort | melanopsin mediates retrograde visual signaling in the retina |
| url | http://europepmc.org/articles/PMC3411794?pdf=render |
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