Comparing the Effect of Memantine and Placebo on Clinical Outcome of Intracranial Hemorrhage: A Randomized Double Blind Clinical Trial
Background: Intracerebral Hemorrhage (ICH) is a stroke type which resulted in disability. Memantine have been supposed to have the effect on the functional status in patients with ICH. Objectives: Comparing the effect of memantine with placebo on the clinical outcome of ICH. Materials and Methods: T...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Guilan University of Medical Sciences
2015-10-01
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| Series: | Caspian Journal of Neurological Sciences |
| Subjects: | |
| Online Access: | http://cjns.gums.ac.ir/browse.php?a_code=A-10-32-20&slc_lang=en&sid=1 |
| _version_ | 1818132793658441728 |
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| author | Babak Bakhshayesh-Eghbali Mohadese Hajinnori Seyed-Mohammad Seyed-Saadat Seyed-Nazanin Seyed-Saadat Ehsan Kazemnezhad-Leili Melina Rouhi-Rad |
| author_facet | Babak Bakhshayesh-Eghbali Mohadese Hajinnori Seyed-Mohammad Seyed-Saadat Seyed-Nazanin Seyed-Saadat Ehsan Kazemnezhad-Leili Melina Rouhi-Rad |
| author_sort | Babak Bakhshayesh-Eghbali |
| collection | DOAJ |
| description | Background: Intracerebral Hemorrhage (ICH) is a stroke type which resulted in disability. Memantine have been supposed to have the effect on the functional status in patients with ICH. Objectives: Comparing the effect of memantine with placebo on the clinical outcome of ICH. Materials and Methods: This double-blind clinical trial was conducted in an academic hospital in northern Iran on patients with ICH allocated in memantine and placebo group through the random block method. The patients’ neurological status was assessed on admission, the seventh day, upon discharge and ultimately three months after the ICH onset, according to the National Institute of Health Stroke Scale (NIHSS), modified Rankin Scale (mRS), Barthel Index (BI) and Glasgow Coma Scale (GCS). The data analysis was done by using independent t-test, Chi-square and repeated measure tests in SPSS software version 21. Results: A total of 64 patients have been allocated into two equal size groups with no significant differences in terms of age or gender (p>0.05). The mean increase in the BI and the decrease in the mRS were significantly greater in the memantine group compared with the placebo group as measured from admission time until three months following the ICH onset (p=0.001 and p=0.049, respectively). No significant differences were observed between the two groups in mortality rate (p=0.492) and the means and changes of the GCS (p=0.331) and the NIHSS score (p=0.211). Conclusion: Early administration of memantine to ICH patients can result in significant improvement of long-term motor function and functional independence. |
| first_indexed | 2024-12-11T08:42:29Z |
| format | Article |
| id | doaj.art-ea03fc14142748b1a4c722195ee43e5d |
| institution | Directory Open Access Journal |
| issn | 2383-4307 2423-4818 |
| language | English |
| last_indexed | 2024-12-11T08:42:29Z |
| publishDate | 2015-10-01 |
| publisher | Guilan University of Medical Sciences |
| record_format | Article |
| series | Caspian Journal of Neurological Sciences |
| spelling | doaj.art-ea03fc14142748b1a4c722195ee43e5d2022-12-22T01:14:13ZengGuilan University of Medical SciencesCaspian Journal of Neurological Sciences2383-43072423-48182015-10-01131118Comparing the Effect of Memantine and Placebo on Clinical Outcome of Intracranial Hemorrhage: A Randomized Double Blind Clinical TrialBabak Bakhshayesh-Eghbali0Mohadese Hajinnori1Seyed-Mohammad Seyed-Saadat2Seyed-Nazanin Seyed-Saadat3Ehsan Kazemnezhad-Leili4Melina Rouhi-Rad5 Neurologist, Assistant Professor, Neurology Department of Poursina Hospital, Guilan University of Medical Sciences, Rasht, Iran Resident of Neurology, Neurology Department of Poursina Hospital, Guilan University of Medical Sciences, Rasht, Iran ; dr.hajinoori@gmail.com General practitioner, Student Research Office, Guilan University of Medical Sciences, Rasht, Iran Medical student, Student Research Office, Guilan University of Medical Sciences, Rasht, Iran Specialist of Biostatistics, Assistant Professor, Guilan Trauma Research Center of Poursina Hospital, Guilan University of Medical Sciences, Rasht, Iran Medical student, Student Research Office, Guilan University of Medical Sciences, Rasht, Iran Background: Intracerebral Hemorrhage (ICH) is a stroke type which resulted in disability. Memantine have been supposed to have the effect on the functional status in patients with ICH. Objectives: Comparing the effect of memantine with placebo on the clinical outcome of ICH. Materials and Methods: This double-blind clinical trial was conducted in an academic hospital in northern Iran on patients with ICH allocated in memantine and placebo group through the random block method. The patients’ neurological status was assessed on admission, the seventh day, upon discharge and ultimately three months after the ICH onset, according to the National Institute of Health Stroke Scale (NIHSS), modified Rankin Scale (mRS), Barthel Index (BI) and Glasgow Coma Scale (GCS). The data analysis was done by using independent t-test, Chi-square and repeated measure tests in SPSS software version 21. Results: A total of 64 patients have been allocated into two equal size groups with no significant differences in terms of age or gender (p>0.05). The mean increase in the BI and the decrease in the mRS were significantly greater in the memantine group compared with the placebo group as measured from admission time until three months following the ICH onset (p=0.001 and p=0.049, respectively). No significant differences were observed between the two groups in mortality rate (p=0.492) and the means and changes of the GCS (p=0.331) and the NIHSS score (p=0.211). Conclusion: Early administration of memantine to ICH patients can result in significant improvement of long-term motor function and functional independence.http://cjns.gums.ac.ir/browse.php?a_code=A-10-32-20&slc_lang=en&sid=1MemantineIntracerebral HemorrhageTreatment Outcome |
| spellingShingle | Babak Bakhshayesh-Eghbali Mohadese Hajinnori Seyed-Mohammad Seyed-Saadat Seyed-Nazanin Seyed-Saadat Ehsan Kazemnezhad-Leili Melina Rouhi-Rad Comparing the Effect of Memantine and Placebo on Clinical Outcome of Intracranial Hemorrhage: A Randomized Double Blind Clinical Trial Caspian Journal of Neurological Sciences Memantine Intracerebral Hemorrhage Treatment Outcome |
| title | Comparing the Effect of Memantine and Placebo on Clinical Outcome of Intracranial Hemorrhage: A Randomized Double Blind Clinical Trial |
| title_full | Comparing the Effect of Memantine and Placebo on Clinical Outcome of Intracranial Hemorrhage: A Randomized Double Blind Clinical Trial |
| title_fullStr | Comparing the Effect of Memantine and Placebo on Clinical Outcome of Intracranial Hemorrhage: A Randomized Double Blind Clinical Trial |
| title_full_unstemmed | Comparing the Effect of Memantine and Placebo on Clinical Outcome of Intracranial Hemorrhage: A Randomized Double Blind Clinical Trial |
| title_short | Comparing the Effect of Memantine and Placebo on Clinical Outcome of Intracranial Hemorrhage: A Randomized Double Blind Clinical Trial |
| title_sort | comparing the effect of memantine and placebo on clinical outcome of intracranial hemorrhage a randomized double blind clinical trial |
| topic | Memantine Intracerebral Hemorrhage Treatment Outcome |
| url | http://cjns.gums.ac.ir/browse.php?a_code=A-10-32-20&slc_lang=en&sid=1 |
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