Chemical Composition of the <i>Cinnamomum malabatrum</i> Leaf Essential Oil and Analysis of Its Antioxidant, Enzyme Inhibitory and Antibacterial Activities
<i>Cinnamomum</i> species are a group of plants belonging to the Lauraceae family. These plants are predominantly used as spices in various food preparations and other culinary purposes. Furthermore, these plants are attributed to having cosmetic and pharmacological potential. <i>C...
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MDPI AG
2023-05-01
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| Series: | Antibiotics |
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| author | Aswathi Moothakoottil Kuttithodi Arunaksharan Narayanankutty Naduvilthara U. Visakh Joice Tom Job Berin Pathrose Opeyemi Joshua Olatunji Ahmed Alfarhan Varsha Ramesh |
| author_facet | Aswathi Moothakoottil Kuttithodi Arunaksharan Narayanankutty Naduvilthara U. Visakh Joice Tom Job Berin Pathrose Opeyemi Joshua Olatunji Ahmed Alfarhan Varsha Ramesh |
| author_sort | Aswathi Moothakoottil Kuttithodi |
| collection | DOAJ |
| description | <i>Cinnamomum</i> species are a group of plants belonging to the Lauraceae family. These plants are predominantly used as spices in various food preparations and other culinary purposes. Furthermore, these plants are attributed to having cosmetic and pharmacological potential. <i>Cinnamomum malabatrum</i> (Burm. f.) J. Presl is an underexplored plant in the <i>Cinnamomum</i> genus. The present study evaluated the chemical composition by a GC-MS analysis and antioxidant properties of the essential oil from <i>C. malabatrum</i> (CMEO). Further, the pharmacological effects were determined as radical quenching, enzyme inhibition and antibacterial activity. The results of the GC-MS analysis indicated the presence of 38.26 % of linalool and 12.43% of caryophyllene in the essential oil. Furthermore, the benzyl benzoate (9.60%), eugenol (8.75%), cinnamaldehyde (7.01%) and humulene (5.32%) were also present in the essential oil. The antioxidant activity was indicated by radical quenching properties, ferric-reducing potential and lipid peroxidation inhibition ex vivo. Further, the enzyme-inhibitory potential was confirmed against the enzymes involved in diabetes and diabetic complications. The results also indicated the antibacterial activity of these essential oils against different Gram-positive and Gram-negative bacteria. The disc diffusion method and minimum inhibitory concentration analysis revealed a higher antibacterial potential for <i>C. malabatrum</i> essential oil. Overall, the results identified the predominant chemical compounds of <i>C. malabatrum</i> essential oil and its biological and pharmacological effects. |
| first_indexed | 2024-03-11T04:00:00Z |
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| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-11T04:00:00Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-ea0426e9190a4ffc858c85bd45829b2a2023-11-18T00:13:37ZengMDPI AGAntibiotics2079-63822023-05-0112594010.3390/antibiotics12050940Chemical Composition of the <i>Cinnamomum malabatrum</i> Leaf Essential Oil and Analysis of Its Antioxidant, Enzyme Inhibitory and Antibacterial ActivitiesAswathi Moothakoottil Kuttithodi0Arunaksharan Narayanankutty1Naduvilthara U. Visakh2Joice Tom Job3Berin Pathrose4Opeyemi Joshua Olatunji5Ahmed Alfarhan6Varsha Ramesh7Division of Cell and Molecular Biology, PG & Research Department of Zoology, St. Joseph’s College (Autonomous), Devagiri, Calicut 673008, Kerala, IndiaDivision of Cell and Molecular Biology, PG & Research Department of Zoology, St. Joseph’s College (Autonomous), Devagiri, Calicut 673008, Kerala, IndiaDepartment of Agricultural Entomology, College of Agriculture, Kerala Agricultural University, Thrissur 680656, Kerala, IndiaDivision of Cell and Molecular Biology, PG & Research Department of Zoology, St. Joseph’s College (Autonomous), Devagiri, Calicut 673008, Kerala, IndiaDepartment of Agricultural Entomology, College of Agriculture, Kerala Agricultural University, Thrissur 680656, Kerala, IndiaAfrican Genome Center, Mohammed VI Polytechnic University, Ben Guerir 43150, MoroccoDepartment of Botany and Microbiology, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi ArabiaDepartment of Biotechnology, Deakin University, Geelong, VIC 3217, Australia<i>Cinnamomum</i> species are a group of plants belonging to the Lauraceae family. These plants are predominantly used as spices in various food preparations and other culinary purposes. Furthermore, these plants are attributed to having cosmetic and pharmacological potential. <i>Cinnamomum malabatrum</i> (Burm. f.) J. Presl is an underexplored plant in the <i>Cinnamomum</i> genus. The present study evaluated the chemical composition by a GC-MS analysis and antioxidant properties of the essential oil from <i>C. malabatrum</i> (CMEO). Further, the pharmacological effects were determined as radical quenching, enzyme inhibition and antibacterial activity. The results of the GC-MS analysis indicated the presence of 38.26 % of linalool and 12.43% of caryophyllene in the essential oil. Furthermore, the benzyl benzoate (9.60%), eugenol (8.75%), cinnamaldehyde (7.01%) and humulene (5.32%) were also present in the essential oil. The antioxidant activity was indicated by radical quenching properties, ferric-reducing potential and lipid peroxidation inhibition ex vivo. Further, the enzyme-inhibitory potential was confirmed against the enzymes involved in diabetes and diabetic complications. The results also indicated the antibacterial activity of these essential oils against different Gram-positive and Gram-negative bacteria. The disc diffusion method and minimum inhibitory concentration analysis revealed a higher antibacterial potential for <i>C. malabatrum</i> essential oil. Overall, the results identified the predominant chemical compounds of <i>C. malabatrum</i> essential oil and its biological and pharmacological effects.https://www.mdpi.com/2079-6382/12/5/940<i>Cinnamomum malabatrum</i>GC-MS analysisessential oilantioxidant activityantibacterial activityenzyme inhibitory activity |
| spellingShingle | Aswathi Moothakoottil Kuttithodi Arunaksharan Narayanankutty Naduvilthara U. Visakh Joice Tom Job Berin Pathrose Opeyemi Joshua Olatunji Ahmed Alfarhan Varsha Ramesh Chemical Composition of the <i>Cinnamomum malabatrum</i> Leaf Essential Oil and Analysis of Its Antioxidant, Enzyme Inhibitory and Antibacterial Activities Antibiotics <i>Cinnamomum malabatrum</i> GC-MS analysis essential oil antioxidant activity antibacterial activity enzyme inhibitory activity |
| title | Chemical Composition of the <i>Cinnamomum malabatrum</i> Leaf Essential Oil and Analysis of Its Antioxidant, Enzyme Inhibitory and Antibacterial Activities |
| title_full | Chemical Composition of the <i>Cinnamomum malabatrum</i> Leaf Essential Oil and Analysis of Its Antioxidant, Enzyme Inhibitory and Antibacterial Activities |
| title_fullStr | Chemical Composition of the <i>Cinnamomum malabatrum</i> Leaf Essential Oil and Analysis of Its Antioxidant, Enzyme Inhibitory and Antibacterial Activities |
| title_full_unstemmed | Chemical Composition of the <i>Cinnamomum malabatrum</i> Leaf Essential Oil and Analysis of Its Antioxidant, Enzyme Inhibitory and Antibacterial Activities |
| title_short | Chemical Composition of the <i>Cinnamomum malabatrum</i> Leaf Essential Oil and Analysis of Its Antioxidant, Enzyme Inhibitory and Antibacterial Activities |
| title_sort | chemical composition of the i cinnamomum malabatrum i leaf essential oil and analysis of its antioxidant enzyme inhibitory and antibacterial activities |
| topic | <i>Cinnamomum malabatrum</i> GC-MS analysis essential oil antioxidant activity antibacterial activity enzyme inhibitory activity |
| url | https://www.mdpi.com/2079-6382/12/5/940 |
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